Metformin: all 1,377 studies that test it

Page 3 of 14. Open to participants first (169), then studies with results posted, then the rest; newest registration first within each.

• Interventions Against Insulin Resistance in Pulmonary Arterial HypertensionCompletedNCT03617458Phase 2Results posted
• Effects of Metformin During Nicotine WithdrawalCompletedNCT03593538Phase 2Results posted
• Glucophage® Extended Release (XR) 750 Milligram (mg) Indonesia Bioequivalence (BE) StudyCompletedNCT03583385Phase 1Results posted
• Glucophage Extended Release (GXR) China Bioequivalence Study (Nantong - Darmstadt)CompletedNCT03566810Phase 1Results posted
• Metformin Pharmacology in Human Cancers: A Proof of Principle StudyTerminatedNCT03477162Early Phase 1Results posted
• Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy ParticipantsCompletedNCT03467945Phase 1Results posted
• Trial of an Intervention to Improve Metformin Persistence and AdherenceCompletedNCT03467763Phase 4Results posted
• Effect of Metformin on Frailty in 12 SubjectsTerminatedNCT03451006Phase 2Results posted
• Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes MellitusCompletedNCT03416127Phase 2Results posted
• Pilot Study of Metformin for Patients With Fanconi AnemiaCompletedNCT03398824Phase 2Results posted
• Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.CompletedNCT03398356Phase 4Results posted
• Glucophage Immediate Release (GIR) China Bioequivalence StudyCompletedNCT03393208Phase 1Results posted
• Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) TrialTerminatedNCT03380091Phase 4Results posted
• Exercise Dose and Metformin for Vascular Health in Metabolic SyndromeCompletedNCT03355469Phase 2/3Results posted
• Cardiometabolic Disease and Pulmonary HypertensionTerminatedNCT03349775Early Phase 1Results posted
• Metformin in Heart Failure Without DiabetesTerminatedNCT03331861Phase 2Results posted
• A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With PrediabetesCompletedNCT03309007Phase 3Results posted
• This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy MenCompletedNCT03307252Phase 1Results posted
• An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on MetforminCompletedNCT03267576Phase 4Results posted
• This Study Tests Whether Taking the Medicines Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills. The Study is Done in Healthy Men and Women and Measures the Amount of Each Medicine in the BloodCompletedNCT03259490Phase 1Results posted
• Diabetes Prevention With Lifestyle Intervention and Metformin EscalationTerminatedNCT03258723Phase 4Results posted
• Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian SyndromeCompletedNCT03117517Early Phase 1Results posted
• Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck CancerCompletedNCT03109873Early Phase 1Results posted
• Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid CancersTerminatedNCT03109847Phase 2Results posted
• Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes MellitusCompletedNCT03106870Not applicableResults posted
• Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell CarcinomaTerminatedNCT03076281Phase 2Results posted
• Improve PAD PERformance With METforminCompletedNCT03054519Phase 3Results posted
• Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by SurgeryStatus unknownNCT03048500Phase 2Results posted
• Metabolic Analysis for Treatment Choice in Gestational Diabetes MellitusCompletedNCT03029702Phase 4Results posted
• Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes MellitusCompletedNCT03010683Not applicableResults posted
• Genomic Outcomes of MetforminCompletedNCT02986659Phase 4Results posted
• RCT Metformin for Reduction of Gestational Diabetes Mellitus EffectsCompletedNCT02980276Phase 3Results posted
• Interaction of Bexagliflozin With Metformin, Glimepiride and SitagliptinCompletedNCT02956044Phase 1Results posted
• Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell CarcinomaCompletedNCT02949700Phase 1/2Results posted
• Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation TherapyTerminatedNCT02946996Phase 2Results posted
• Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)TerminatedNCT02932475Phase 3Results posted
• Metformin as an Upstream Therapy in Atrial FibrillationTerminatedNCT02931253Phase 2Results posted
• Feasibility Study of Metformin Therapy in ADPKDCompletedNCT02903511Phase 2Results posted
• A Study of the Effect of Abemaciclib on Metformin and Iohexol in Healthy ParticipantsCompletedNCT02884089Phase 1Results posted
• Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine CancerTerminatedNCT02874430Phase 2Results posted
• Transporter Cocktail Mutual InteractionCompletedNCT02854527Phase 1Results posted
• Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?CompletedNCT02846233Not applicableResults posted
• DA-EPOCH-Rituximab/Metformin (RM) for Double Hit LymphomaTerminatedNCT02815397Phase 2Results posted
• MEtformin and Lorcaserin for WeighT Loss in SchizophreniaTerminatedNCT02796144Phase 4Results posted
• An Open-label, Randomized, Crossover Study of Comparative Pharmacokinetics and Bioequivalence of Dapagliflozin + Metformin, 10 mg + 1000 mg Versus the Combined Use of Forxiga™, 10 mg and Two Glucophage® Long, ER Tablets, 500 mg Co-administered to Healthy Volunteers Under Standard Fed ConditionsCompletedNCT02722239Phase 1Results posted
• Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMDCompletedNCT02684578Phase 2Results posted
• Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney DiseaseCompletedNCT02656017Phase 2Results posted
• EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)CompletedNCT02635386Phase 3Results posted
• Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic SyndromeCompletedNCT02633488Not applicableResults posted
• Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Sitagliptin (REMIT-Sita)CompletedNCT02623998Phase 3Results posted
• Bicalutamide With or Without Metformin for Biochemical Recurrence in Overweight or Obese Prostate Cancer PatientsCompletedNCT02614859Phase 2Results posted
• Metformin for the Prevention of Episodic Migraine (MPEM)CompletedNCT02593097Phase 3Results posted
• Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant LesionActive, not recruitingNCT02581137Phase 2Results posted
• Demonstrate Bioequivalence of Two 12.5 mg Empagliflozin/500 mg Metformin Fixed Dose Combination Tablets With Free Combination of Empagliflozin 25 mg and Metformin 1000 mg in Healthy Male and Female Volunteers Under Fed ConditionsCompletedNCT02577315Phase 1Results posted
• DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)CompletedNCT02574845Phase 1Results posted
• Metformin for Preventing Frailty in High-risk Older AdultsCompletedNCT02570672Phase 2Results posted
• Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide MetforminCompletedNCT02552355Phase 2Results posted
• A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on MetforminCompletedNCT02551874Phase 3Results posted
• Metformin in Combination With Standard Induction Therapy for Large B-cell Lymphoma (DLBCL)TerminatedNCT02531308Phase 2Results posted
• Dose-Ranging Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Metformin Delayed Release in Subjects With T2DMCompletedNCT02526524Phase 2Results posted
• Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAsCompletedNCT02515773Phase 4Results posted
• Heart Rate Variability in Response to Metformin ChallengeCompletedNCT02500628Phase 2Results posted
• Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)TerminatedNCT02500147Phase 4Results posted
• Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian SyndromeCompletedNCT02498522Early Phase 1Results posted
• Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaTerminatedNCT02495103Phase 1/2Results posted
• Use of Metformin to Reduce Cardiac Toxicity in Breast CancerTerminatedNCT02472353Phase 2Results posted
• Three New Ideas to Protect Special Forces From the Stress of High AltitudeCompletedNCT02463357Phase 4Results posted
• An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic PatientsCompletedNCT02435277Phase 2Results posted
• Metformin in Longevity Study (MILES).CompletedNCT02432287Phase 4Results posted
• Survivorship Promotion In Reducing IGF-1 TrialCompletedNCT02431676Phase 2Results posted
• Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation TherapyTerminatedNCT02420652Phase 2Results posted
• Metformin for Rising PSA Remote TrialCompletedNCT02376166Not applicableResults posted
• Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast CancerTerminatedNCT02360059Phase 2Results posted
• Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell CarcinomaCompletedNCT02325401Phase 1Results posted
• Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)CompletedNCT02308228Early Phase 1Results posted
• Assessing the PK of Met DR, Met IR, and Met XR in Healthy SubjectsCompletedNCT02291510Phase 1Results posted
• Metformin in Non Small Cell Lung Cancer (NSCLC)TerminatedNCT02285855Phase 2Results posted
• Use of Metformin in Treatment of Childhood ObesityCompletedNCT02274948Phase 4Results posted
• Evaluate the Efficacy and Safety of Saxagliptin in Combination With Metformin IR Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Drug Naive Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic ControlCompletedNCT02273050Phase 3Results posted
• Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Male and FemaleCompletedNCT02266472Phase 1Results posted
• Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 DiabetesCompletedNCT02252965Phase 4Results posted
• Metformin in Kidney DiseaseCompletedNCT02252081Phase 2Results posted
• Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy SubjectsCompletedNCT02230995Phase 1Results posted
• Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung CancerCompletedNCT02186847Phase 2Results posted
• Metformin to Augment Low Milk Supply (MALMS) StudyCompletedNCT02179788Phase 1/2Results posted
• Metformin Prostate Cancer Adjuvant TrialCompletedNCT02176161Phase 2Results posted
• Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic PatientsCompletedNCT02151461Phase 2Results posted
• Effects of Metformin and Fish Oil on Treatment With ClozapineTerminatedNCT02140788Phase 4Results posted
• Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal CancerCompletedNCT02122185Phase 2Results posted
• Bioequivalence of a FDC Tablet of Linagliptin/Metformin (2.5mg/750mg) Extended Release in Healthy SubjectsCompletedNCT02121509Phase 1Results posted
• Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Metformin Extended Release (XR) Compared With Single TabletsCompletedNCT02106923Phase 1Results posted
• Bioavailability of Empagliflozin/Metformin Fixed Dose Combinations (FDCs) in Healthy Chinese VolunteersCompletedNCT02102932Phase 1Results posted
• Effectiveness and Safety of Adding Compound Preparation of Pioglitazone and Metformin for Type 2 Diabetic PatientsCompletedNCT02099838Phase 4Results posted
• Bioequivalence of a FDC Tablet of Linagliptin/Metformin (5mg/1000mg) Extended Release in Healthy SubjectsCompletedNCT02084082Phase 1Results posted
• Bioequivalence of a FDC Tablet of Linagliptin/Metformin (2.5mg/1000mg) Extended Release in Healthy Subjects.CompletedNCT02084056Phase 1Results posted
• Endogenous Opioid Activity and Affective State in Insulin Resistant WomenCompletedNCT02069379Phase 4Results posted
• Comparative Study to Evaluate Efficacy and Safety When Metformin Hydrochloride 500 mg Once Daily is Added on to SYR-322 25 mg in Type 2 Diabetic Patients With Inadequate Glycemic Control Despite Treatment With SYR-322 25 mg in Addition to Diet and Exercise TherapyCompletedNCT02068443Phase 3Results posted
• Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial CancerStatus unknownNCT02065687Phase 2/3Results posted
• Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical PatientsCompletedNCT02035787Phase 2Results posted
• Bioequivalence Study in Healthy Volunteers for Empagliflozin/Metformin Fixed Dose Combination Compared to Separate TabletsCompletedNCT02028767Phase 1Results posted

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