Metformin: all 1,377 studies that test it

Page 2 of 14. Open to participants first (169), then studies with results posted, then the rest; newest registration first within each.

• The Nephroprotective Effect of Metformin With Cisplatin in Bladder CancerRecruitingNCT06215976Phase 4
• Effect of Unani Medicine for the Management of Anomalies Associated With Polycystic Ovarian SyndromeRecruitingNCT06199544Phase 1
• Metformin and Muscle RecoveryRecruitingNCT06185179Early Phase 1
• Metformin and Lactoferrin in Sepsis in IcuRecruitingNCT06181422Phase 2/3
• The Effects of DPPIs on Cognitive Function of Diabetic PatientsNot yet recruitingNCT06164535Phase 4
• Effect of Metformin in Reducing Fatigue in Long COVID in AdolescentsNot yet recruitingNCT06147050Phase 3
• Efficacy of Vildagliptin Versus Metformin in Poly Cystic Ovary SyndromeRecruitingNCT06142656Phase 2/3
• Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients.RecruitingNCT06126029Phase 2
• Effect of Moringa Leaf Capsules on Glycemic Control of Type 2 Diabetic PatientsEnrolling by invitationNCT06125873Phase 2
• Precision Dosing of Metformin in Youth With T2DRecruitingNCT06120881Early Phase 1
• Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin ResistanceNot yet recruitingNCT06096454Phase 4
• Preventing Injured Knees From osteoArthritis: Severity OutcomesRecruitingNCT06096259Phase 2
• Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata.Not yet recruitingNCT06087796Phase 1
• The Effect of Addition of Metformin to SGLT2 In Diabetic Patients With Heart Failure With Preserved Ejection FractionNot yet recruitingNCT06080802Phase 2/3
• A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation TherapyRecruitingNCT06044025Phase 1
• The Effect of Related Blood Markers on Diabetic Peripheral NeuropathyRecruitingNCT06041399Phase 4
• PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm PreeclampsiaRecruitingNCT06033131Phase 3
• Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic InfertilityNot yet recruitingNCT06012682Phase 2
• Clinical Evaluation of the Effect of Metformin in SepsisRecruitingNCT05979038Phase 3
• Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and InfertilityNot yet recruitingNCT05952882Phase 3
• Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade GliomaRecruitingNCT05929495Phase 2
• Metformin for the Treatment of Microvascular Dysfunction After Gestational DiabetesRecruitingNCT05917587Early Phase 1
• Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony DefectsEnrolling by invitationNCT05906563Phase 2
• Metformin for Fibromyalgia Symptoms (INFORM Trial)RecruitingNCT05900466Phase 2
• METFORMIN FOR ATRIAL FIBRILLATIONNot yet recruitingNCT05878535Phase 2
• The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection FractionRecruitingNCT05847244Phase 2
• Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes MellitusRecruitingNCT05779644Not applicable
• Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual DisabilityRecruitingNCT05744479Phase 4
• Glycaemic & Cardiovascular Treatment Outcomes of Voglibose Vs Glibenclamide Added to Metformin in T2DM PatientsNot yet recruitingNCT05688332Phase 3
• Treatment With Metformin in Chinese Children With Alport SyndromeNot yet recruitingNCT05655728Phase 4
• Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)Not yet recruitingNCT05646199Phase 2/3
• Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled TrialRecruitingNCT05580523Not applicable
• Metformin as Added on Therapy in Patients With Ulcerative ColitisRecruitingNCT05574387Phase 2
• Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer PatientsRecruitingNCT05515978Early Phase 1
• Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid CancerRecruitingNCT05468554Phase 3
• Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR MutationsRecruitingNCT05445791Phase 3
• Metformin as a Neuroprotective Therapy for GlaucomaRecruitingNCT05426044Phase 2
• The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin ActionRecruitingNCT05414409Phase 2
• Metformin to Prevent Preterm Birth in Twin PregnancyNot yet recruitingNCT05412056Phase 2/3
• A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)RecruitingNCT05394142Phase 2
• "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary SyndromeRecruitingNCT05305898Phase 3
• Efficacy and Tolerability of Adjunct Metformin for Multibacillary LeprosyRecruitingNCT05243654Phase 2
• Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain TumourRecruitingNCT05230758Phase 3
• MetfOrmin BenefIts Lower Extremities With Intermittent ClaudicationRecruitingNCT05132439Phase 3
• MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 DiabetesRecruitingNCT05065372Phase 1
• Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)RecruitingNCT05041907Phase 2
• COAST Therapy in Advanced Solid Tumors and Prostate CancerRecruitingNCT05036226Phase 1/2
• Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy TemozolomideRecruitingNCT04945148Phase 2
• Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)RecruitingNCT04939935Phase 3
• Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of RelapseRecruitingNCT04758000Phase 2
• Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDSRecruitingNCT04741945Phase 2
• Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard CareRecruitingNCT04581447Phase 3
• Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel FunctionRecruitingNCT04530383Phase 2
• The Effects of Metformin on Morbidity and Mortality in Elderly PatientsNot yet recruitingNCT04530058Phase 2
• Limiting AAA With Metformin (LIMIT) TrialRecruitingNCT04500756Phase 2
• Metformin for Abdominal Aortic Aneurysm Growth InhibitionEnrolling by invitationNCT04224051Phase 2
• A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple SclerosisRecruitingNCT04121468Phase 1/2
• Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor MalignanciesRecruitingNCT04114136Phase 2
• High Dose Vitamin C Combined With Metformin in the Treatment of Malignant TumorsRecruitingNCT04033107Phase 2
• Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese PatientsRecruitingNCT03974139Phase 2
• RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial CancerRecruitingNCT03675893Phase 2
• A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast CancerRecruitingNCT03424005Phase 1/2
• Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder CancerRecruitingNCT03379909Phase 2
• Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)RecruitingNCT02969798Not applicable
• Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomesRecruitingNCT02915198Phase 4
• Acupuncture or Metformin for Insulin Resistance in Women With PCOSRecruitingNCT02647827Phase 2
• Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different RegimensRecruitingNCT02587741Early Phase 1
• A Phase I/II Trial of Vemurafenib and Metformin to Melanoma PatientsRecruitingNCT01638676Phase 1/2
• Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422746Early Phase 1
• A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the BloodCompletedNCT06504862Phase 1Results posted
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)CompletedNCT06042855Phase 3Results posted
• Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or ErythroplakiaActive, not recruitingNCT05237960Phase 2Results posted
• A Study in Healthy Humans to Assess the Relative Bioavailability of One Fixed-dose Combination Tablet Empagliflozin/Metformin Versus Jardiance® Tablet and Glifage® Tablet Administered TogetherCompletedNCT05083949Phase 1Results posted
• Drug-Drug Interaction Study of Evobrutinib and Transporter SubstratesCompletedNCT05064488Phase 1Results posted
• Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)CompletedNCT04930744Phase 2Results posted
• Study of Safety and Efficacy of Dapagliflozin + Metformin XR Versus Metformin XR in Participants With HR+, HER2-, Advanced Breast Cancer While on Treatment With Alpelisib and FulvestrantTerminatedNCT04899349Phase 2Results posted
• ACTIV-6: COVID-19 Study of Repurposed MedicationsCompletedNCT04885530Phase 3Results posted
• Investigation of Metformin for the Prevention of Progression of Precursor Multiple MyelomaActive, not recruitingNCT04850846Phase 2Results posted
• GXR RM (Glucophage® Extended Release Reduced Mass) 500 Milligram (mg) Korea Bioequivalence (BE) StudyCompletedNCT04684420Phase 1Results posted
• Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial FibrillationCompletedNCT04625946Phase 4Results posted
• A Study in Healthy People to Test Whether BI 730357 Affects How 4 Other Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Taken up in the BodyCompletedNCT04590937Phase 1Results posted
• COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)CompletedNCT04510194Phase 3Results posted
• Impact of Metformin on Immuno-virologic Parameters in HIVTerminatedNCT04500678Phase 2/3Results posted
• Oral Anti Diabetic Agents in the HospitalTerminatedNCT04416269Phase 4Results posted
• Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer PatientsActive, not recruitingNCT04414540Phase 2Results posted
• A Study to Assess Safety of Canagliflozin and Metformin Hydrochloride Combination Given as a Supplement to Diet and Exercise to Improve Blood Sugar Level in Indian Adult Participants With DiabetesCompletedNCT04288778Phase 4Results posted
• Antecedent Metabolic Health and Metformin Aging StudyCompletedNCT04264897Phase 3Results posted
• Diet and Exercise Plus Metformin to Treat Frailty in Obese SeniorsCompletedNCT04221750Phase 3Results posted
• Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTDActive, not recruitingNCT04220021Phase 2Results posted
• Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)CompletedNCT04209075Phase 2Results posted
• Effects of Metformin on Low Back PainTerminatedNCT04055012Phase 2Results posted
• Metabolic and Neuro-Endocrine Effect of Treating PCOS in AdolescentsCompletedNCT03981861Phase 2/3Results posted
• Effectiveness of Dapagliflozin for Weight LossCompletedNCT03968224Phase 2/3Results posted
• REMAP Trial for Optimizing Surgical Outcomes at UPMCTerminatedNCT03861767Phase 3Results posted
• Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal CancerCompletedNCT03800602Phase 2Results posted
• Study of PF 04965842 Effect on MATE1/2K Activity in Healthy ParticipantsCompletedNCT03796182Phase 1Results posted
• Effects of Metformin in a Non-Diabetic Patient PopulationCompletedNCT03772964Phase 1/2Results posted
• Metformin Effect on Brain Function in Insulin Resistant Elderly PeopleCompletedNCT03733132Phase 2Results posted
• Metformin to Reduce Airway Glucose in COPD PatientsCompletedNCT03651895Phase 2Results posted
• This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate PillsCompletedNCT03629054Phase 1Results posted

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