Letrozole: all 366 studies that test it

Page 1 of 4. Open to participants first (56), then studies with results posted, then the rest; newest registration first within each.

• A Study to Evaluate the Effects of GDC-4198 in Combination With Letrozole, Fulvestrant, or Giredestrant in Participants With Locally Advanced or Metastatic Hormone Receptor-Positive, HER2-Negatve Breast CancerNot yet recruitingNCT07867262Phase 1
• De-EscaLaTion of Aromatase Inhibitor Therapy: A Randomized Phase II Study of De-escalated Letrozole in Hormone Receptor-Positive Early Breast CancerNot yet recruitingNCT07866430Phase 2
• Culmerciclib Combined With Letrozole and Dual HER2 Blockade as Neoadjuvant Therapy for HR+/HER2+ Breast CancerNot yet recruitingNCT07795424Phase 2
• Kumorixilib Plus Capecitabine and Letrozole for Neoadjuvant Treatment of HR-Positive HER2-Negative Breast CancerNot yet recruitingNCT07691333Phase 2
• Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA TrialNot yet recruitingNCT07676331Phase 2
• Letrozole Versus Methotrexate for Management of Undisturbed Ectopic PregnancyNot yet recruitingNCT07624903Phase 2
• FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural CyclesRecruitingNCT07425990Not applicable
• Neoadjuvant Letrozole in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative, Node Positive, Early-Stage Breast Cancer.Not yet recruitingNCT07394946Phase 2
• A Study of HRS-6208 in Combination With HRS-8080, or Fulvestrant, or Letrozole, With or Without HRS-6209 in Patients With Advanced Unresectable or Metastatic Breast CancerRecruitingNCT07389733Phase 1/2
• Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular ClassificationRecruitingNCT07319429Phase 2/3
• Clinical Study of SHR-A1811 With or Without Letrozole in Neoadjuvant Therapy for Early-Stage HR-Positive, HER2-Low Breast CancerNot yet recruitingNCT07305246Phase 2
• Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed MiscarriageRecruitingNCT07160855Phase 4
• Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of MiscarriageRecruitingNCT07109947Not applicable
• A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)RecruitingNCT06979596Phase 2
• FET in AdenomyosisNot yet recruitingNCT06913075Not applicable
• Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)RecruitingNCT06757634Phase 3
• Letrozole Versus Mifepristone and Misoprostol in Silent MiscarriageNot yet recruitingNCT06733727Not applicable
• Combination Letrozole and Clomiphene Citrate Versus Letrozole AloneRecruitingNCT06507332Not applicable
• A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of RecurrenceRecruitingNCT06492616Phase 3
• A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian CancerRecruitingNCT06394804Phase 2
• Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast CancerRecruitingNCT06380751Phase 3
• GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer PatientsRecruitingNCT06379113Phase 2/3
• ALPINE: Maintenance Letrozole/AbemaciclibRecruitingNCT06366347Phase 2
• Use of Letrozole for Ectopic PregnancyRecruitingNCT06354439Phase 4
• Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After SurgeryRecruitingNCT06348134Phase 2
• Dalpiciclib Combined With Letrozole in HR+/HER2 - Gynecologic Solid TumorsRecruitingNCT06243185Phase 2
• Optimizing Extended Adjuvant Endocrine Therapy in Patients With Breast CancerNot yet recruitingNCT06223698Phase 3
• Endometrial Preparation in Frozen Embryo Transfer CyclesRecruitingNCT06181305Phase 4
• Prescription of Letrozole for Uterine MyomaRecruitingNCT06143631Phase 4
• RADIANT: Pre-op Radiation With Abemaciclib and LetrozoleRecruitingNCT06139107Phase 1
• The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)RecruitingNCT06006091Not applicable
• Abemaciclib and Letrozole in Patients With Estrogen Receptor-positive Rare Ovarian CancerRecruitingNCT05872204Phase 2
• Select the Appropriate Population for Adding CDK4/6i to Neoadjuvant Endocrine TherapyRecruitingNCT05809024Phase 4
• Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic MalignanciesRecruitingNCT05705505Phase 1/2
• Letrozole in Uterine LeiomyosarcomaRecruitingNCT05649956Phase 2
• Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA StudyEnrolling by invitationNCT05645536Phase 3
• Pyrotinib Combined With Trastuzumab, Dalpiciclib, Letrozole Versus TCbHP (Trastuzumab Plus Pertuzumab With Docetaxel and Carboplatin) as Neoadjuvant Treatment in HR +/HER2 + Breast CancerRecruitingNCT05638594Phase 2
• Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial)RecruitingNCT05601700Phase 3
• Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant TherapyRecruitingNCT05582499Phase 2
• Vitamin D and Calcium Supplementation in Breast CancerRecruitingNCT05523609Phase 2/3
• Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian CystectomyRecruitingNCT05487092Not applicable
• The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of PregnancyRecruitingNCT05341817Phase 4
• GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia PatientsRecruitingNCT05316935Phase 2/3
• Pyrotinib Maleate, Trastuzumab, SHR6390 and Letrozole in Combination for Stage II-III TPBCRecruitingNCT05228951Phase 2
• Lenvatinib+Letrozole Versus Fulvestrant in Metastatic ER+/HER2- Breast Cancer, Post Progression on Al + CDK4/6 InhibitorRecruitingNCT05181033Phase 2
• Letrozole Plus Metronomic Capecitabine as First-line Treatment for Patients With Recurrent or Metastatic Breast CancerNot yet recruitingNCT04942899Phase 2
• A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial CancerRecruitingNCT04486352Phase 1/2
• IUI With Letrozole Versus in Natural CycleRecruitingNCT04169451Not applicable
• MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO)RecruitingNCT04111978Phase 3
• A Window of Opportunity Study of Pre-operative Endocrine Therapy With and Without Prometrium in Postmenopausal Women With Early Stage Breast Hormone Receptor Positive (HR+) Human Epidermal Receptor 2 Negative (HER2-) Breast Cancer.RecruitingNCT03906669Phase 2
• RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial CancerRecruitingNCT03675893Phase 2
• Signal TrAnsduction Pathway Activity Analysis in OVarian cancERRecruitingNCT03458221Phase 2/3
• A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast CancerRecruitingNCT03424005Phase 1/2
• Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors TrialRecruitingNCT03011684Phase 3
• The Letrozole Administration During Luteal PhaseNot yet recruitingNCT02686151Phase 3
• I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast CancerRecruitingNCT01042379Phase 2
• A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic CancerTerminatedNCT06630325Phase 2Results posted
• Letrozole in Patients With Hepatopulmonary SyndromeTerminatedNCT04577001Phase 2Results posted
• Anastrozole and Letrozole After Surgery for the Treatment of Stage I-III Breast CancerCompletedNCT04294225Phase 2Results posted
• Neoadjuvant Study Chemotherapy vs Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk Breast Cancer PatientsActive, not recruitingNCT04293393Phase 2Results posted
• The Effects of Short-term Preoperative Treatment With Hormonal Therapy on Gene Profiles in Breast CancerCompletedNCT04129216Phase 2Results posted
• Assessment and Prevention of Pain During Ovarian Stimulation in Patients With EndometriosisCompletedNCT04002141Phase 2Results posted
• Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast CancerCompletedNCT03774472Phase 1/2Results posted
• Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast CancerCompletedNCT03747042Phase 2Results posted
• Ribociclib and Letrozole Treatment in Ovarian CancerActive, not recruitingNCT03673124Phase 2Results posted
• Testing the Effects of Palbociclib and Fulvestrant or Letrozole for Patients 70 Years of Age of Older With Metastatic Breast CancerCompletedNCT03633331Phase 2Results posted
• Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus FulvestrantTerminatedNCT03439046Phase 3Results posted
• PF-06804103 Dose Escalation in HER2 Positive and Negative (Negative Only in Part 2) Solid TumorsTerminatedNCT03284723Phase 1Results posted
• Neoadjuvant Endocrine Therapy in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Node-Negative Breast CancerCompletedNCT03219476Phase 2Results posted
• Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast CancerCompletedNCT03096847Phase 3Results posted
• Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior TreatmentsCompletedNCT03056755Phase 2Results posted
• Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBCCompletedNCT02941926Phase 3Results posted
• Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab in Stage II-III ER+ HER2+ Breast CancerTerminatedNCT02907918Phase 2Results posted
• Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast CancerActive, not recruitingNCT02778685Phase 2Results posted
• Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)Active, not recruitingNCT02764541Phase 2Results posted
• A Study of Abemaciclib (LY2835219) in Participants With Breast CancerActive, not recruitingNCT02763566Phase 3Results posted
• Palbociclib In Combination With Letrozole As Treatment Of Post-Menopausal Women With HR+, HER2- Advanced Breast CancerCompletedNCT02679755Phase 4Results posted
• Ribociclib and Letrozole in Treating Patients With Relapsed ER Positive Ovarian, Fallopian Tube, Primary Peritoneal, or Endometrial CancerCompletedNCT02657928Phase 2Results posted
• Palbociclib Plus Letrozole For Postmenopausal Women With HR(+) HER2(-) Advanced Breast Cancer For Whom Letrozole Is Deemed AppropriateCompletedNCT02600923Phase 3Results posted
• Combination of Letrozole, Everolimus and TRC105 in Postmenopausal Women With Hormone-Receptor Positive and Her2 Negative Breast CancerCompletedNCT02520063Phase 1/2Results posted
• Pilot of Letrozole for Uterine MyomasCompletedNCT02470741Phase 4Results posted
• Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH.CompletedNCT02389088Not applicableResults posted
• Study Evaluating the Timing of Intrauterine Insemination in Relation to Positive Home Ovulation Prediction KitCompletedNCT02294773Not applicableResults posted
• Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity CancerCompletedNCT02283658Phase 2Results posted
• Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial CancerCompletedNCT02228681Phase 2Results posted
• ER Reactivation Therapy for Breast CancerCompletedNCT02188745Phase 2Results posted
• Aromatase Inhibitor Growth Study: Letrozole vs. AnastrozoleCompletedNCT02137538Phase 4Results posted
• GCC 1366: Anti-Proliferative Response to NeoAdjuvant AIs in Overweight and Obese PatientsTerminatedNCT02095184Not applicableResults posted
• To Assess Safety and Effect of Olaparib on the Pharmacokinetics of Anastrozole, Letrozole & Tamoxifen, and Their Effect on Olaparib, in Patients With Advanced Solid CancerCompletedNCT02093351Phase 1Results posted
• Presurgical Treatment With Letrozole in Patients With Early-stage Breast Cancer.CompletedNCT02010021Not applicableResults posted
• The Role of Estrogen in Luteinizing Hormone Surge and OvulationCompletedNCT01999569Phase 4Results posted
• BYL719 Plus Letrozole or Exemestane for Patients With Hormone-Receptor Positive Locally-Advanced Unresectable or Metastatic Breast CancerCompletedNCT01870505Phase 1Results posted
• A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial CarcinomaCompletedNCT01797523Phase 2Results posted
• Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast CancerCompletedNCT01698918Phase 2Results posted
• A Study Of Oral Palbociclib (PD-0332991), A CDK4/6 Inhibitor, As Single Agent In Japanese Patients With Advanced Solid Tumors Or In Combination With Letrozole For The First-Line Treatment Of Postmenopausal Japanese Patients With ER (+) HER2 (-) Advanced Breast CancerCompletedNCT01684215Phase 2Results posted
• Aromatase Inhibitor Host Factors StudyCompletedNCT01669343Not applicableResults posted
• Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) With Leuprolide + Letrozole and (3) Everolimus + EDT in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLL-HCC)CompletedNCT01642186Phase 2Results posted
• Letrozole and Lapatinib Followed by Everolimus in Women With Advanced Breast CancerTerminatedNCT01499160Phase 2Results posted
• Reproductive Hormonal Alterations in ObesityCompletedNCT01457703Not applicableResults posted
• Letrozole in Treating Postmenopausal Women With Ductal Carcinoma in SituCompletedNCT01439711Phase 2Results posted

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