Hepatitis B, Chronic clinical trials
The registry lists 895 studies for Hepatitis B, Chronic across more than 10 countries. 151 are recruiting or about to start. 842 of them are mainly about Hepatitis B, Chronic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
ClinicalTrials.gov finds 1,210 studies for Hepatitis B, Chronic. How that becomes 895 here
This page counts the studies the registry files under Hepatitis B, Chronic, and those it files under no condition that list Hepatitis B, Chronicthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,210Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −16List Hepatitis B, Chronic as a condition, but the registry did not file them under itMost often written as “Hepatitis B, Chronic (CHB)” (3), “Hepatitis B Chronic Infection” (2), and “HBe Negative Chronic Hepatitis B” (1). The registry filed them under other conditions only, most often Hepatitis B (11) and Bronchiolitis Obliterans Syndrome (4).
- −299Match it another way167 name it in the title, 3 in a keyword, and 129 by a synonym or other text the search reads.
- 895The count on this page30 of them list Hepatitis B, Chronic in their own words; the registry filed them under no condition.
Get an email when these change. Save the Hepatitis B, Chronic studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Hoffmann-La Roche (46) · Gilead Sciences (34) · Third Affiliated Hospital, Sun Yat-Sen University (29) · GlaxoSmithKline (28) · Beijing Ditan Hospital (27) · Bristol-Myers Squibb (24) · Nanfang Hospital, Southern Medical University (21) · Assembly Biosciences (17)
What is being tested here
Drugs under test in Hepatitis B, Chronic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Immune checkpoint inhibitors 6 open · Reverse transcriptase inhibitors 94
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026To Evaluate the Efficacy, Safety and Population Pharmacokinetics of GST-HG141 in Patients With Chronic Hepatitis B (CHB) Who Have an Inadequate Response to Antiviral Drug Treatment · Phase 3 · Fujian Akeylink Biotechnology Co., Ltd.
- Dec 2026Study of AHB-137 in Participants With Chronic Hepatitis B (CHB) Treated With Nucleos(t)Ide Analogues (NAs)(AUSHINE) · Phase 3 · Ausper Biopharma Co., Ltd.
- Dec 2026A Small Sample Prospective Clinical Study of Azvudine Tablets to Promote Clinical Cure in Patients With Chronic Hepatitis B · Phase 3 · Zhigang Ren
- Jun 2027A Phase II/III of Hepenofovir Fumarate Tablets (HTS) for Chronic Hepatitis B · Phase 3 · Xi'an Xintong Pharmaceutical Research Co.,Ltd.
- Nov 2026Clinical Study of Antiviral Therapy Combined With Novel Immunotherapy for CHB in Adults · Beijing Ditan Hospital
- Nov 2026Long-term Outcomes of Anti-viral Therapies in Patients With Chronic Viral Hepatitis B · Huashan Hospital
- Nov 2026Hepatitis Delta Virus Infection: Cross-sectional Study in Patients With Chronic Hepatitis B Virus Infection · Tam Anh Research Institute
- Nov 2026Assessment of Treatment Adherence and Associated Factors in Chronic HepB Patients Supported by HBVCare · Institute of Gastroenterology and Hepatology, Vietnam
- Dec 2026Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B · Precision BioSciences, Inc.
- Dec 2026Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease · Humanity and Health Research Centre
Who these studies take
Of the 96 Hepatitis B, Chronic studies recruiting now, 33 (34%) set no upper age limit and 58 (60%) stop at 75 or younger. 11 (11%) take children under 18. 3 (3%) are for women only and 0 (0%) for men only; 13 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (8%) | 7 (7%) |
| 18 | 86 (90%) | 85 (89%) |
| 30 | 93 (97%) | 90 (94%) |
| 40 | 95 (99%) | 92 (96%) |
| 50 | 92 (96%) | 91 (95%) |
| 65 | 78 (81%) | 77 (80%) |
| 75 | 40 (42%) | 39 (41%) |
| 85 | 33 (34%) | 32 (33%) |
Across all 895 studies, recruiting or not: 67% stop at 75 or younger and 47% at 65; 11% take children; 3% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hepatitis B, Chronic studies take
Of 87 phase 2 interventional studies under Hepatitis B, Chronic, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 16 mo6–27 · 81 studies | 15 mo5–26 · 73 studies | — |
| Phase 2 | 23 mo16–41 · 87 studies | 22 mo15–39 · 75 studies | — |
| Phase 3 | 33 mo21–47 · 24 studies | — | — |
| Phase 4 | 43 mo30–64 · 63 studies | — | 47 mo40–83 · 46 studies |
| Interventional, no phase | 44 mo21–121 · 42 studies | — | — |
| Observational | 55 mo31–99 · 71 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Entecavir Resistance-Associated Mutations in Chronic HBV Patients in Turkey (STREAM Study)Oct 13, 2026NCT07459426
Newly registered7
- A Study of HT-101 and HT-102 in Chronic Hepatitis B (CHB)Nov 5, 2026NCT07917910
- A Phase I Clinical Trial of CPU-YL01 Injection in Patients With Chronic Hepatitis B.Nov 5, 2026NCT07918456
- B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study ParticipantsNov 2, 2026NCT07908459
- Phase Ia/Ib Trial of SCTA02A Injection in Healthy Adults and Patients With Chronic Hepatitis BOct 29, 2026NCT07903831
- A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB)Oct 27, 2026NCT07897448
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Studies
Recruiting first, then most recently updated. Showing 50 of 895. Browse all 895 → or search them.
- A Phase I Clinical Trial of CPU-YL01 Injection in Patients With Chronic Hepatitis B.Enrolling by invitationNCT07918456Phase 11 country
- A Study of HT-101 and HT-102 in Chronic Hepatitis B (CHB)Not yet recruitingNCT07917910Phase 2
- B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study ParticipantsNot yet recruitingNCT07908459Phase 4
- Phase Ia/Ib Trial of SCTA02A Injection in Healthy Adults and Patients With Chronic Hepatitis BNot yet recruitingNCT07903831Phase 11 country
- Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe RegionsRecruitingNCT07654283Phase 26 countries
- A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB)Not yet recruitingNCT07897448Phase 1/2
- A Study to Evaluate the Efficacy and Safety of Combination Therapy of BRII-179, BRII-835 and PEG-IFNα in Participants With Chronic Hepatitis B Virus (HBV) Infection (ENHANCE)RecruitingNCT06650852Phase 21 country
- A Clinical Study of AHB-121 in Healthy Participants and Chronic Hepatitis B (CHB) ParticipantsNot yet recruitingNCT07884864Phase 11 country
- A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB)Not yet recruitingNCT07876856Phase 1/2
- Entecavir Resistance-Associated Mutations in Chronic HBV Patients in Turkey (STREAM Study)RecruitingNCT074594261 country
- Phase 2 Study of AHB-137 in HBeAg Negative Chronic Hepatitis B (CHB) Participants in Asia Pacific RegionRecruitingNCT07370207Phase 27 countries
- Clinical Trial of TQA3605 Tablet in Combination With Nucleos(t)Ide Analogues(NAs) Versus NAs Alone for the Treatment of Patients With Chronic Hepatitis B Virus Infection Who Have Undergone Treatment and Exhibit Low Viral Load or Poor ResponseNot yet recruitingNCT07797231Phase 31 country
- Impact of Functional Cure of Chronic Hepatitis B on Patient-Reported Outcomes (PROs)RecruitingNCT078550291 country
- Hepatitis Delta Virus Infection: Cross-sectional Study in Patients With Chronic Hepatitis B Virus InfectionRecruitingNCT066383201 country
- A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (A)RecruitingNCT07852091Phase 21 country
- A Study on IB-001 Dose Response and Tolerability in Healthy Adults and Those With Chronic Hepatitis BRecruitingNCT07389044Phase 14 countries
- A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (B)RecruitingNCT07845058Phase 21 country
- A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (A)RecruitingNCT05769816Phase 21 country
- Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of ACT500 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Complicated With Chronic Hepatitis BNot yet recruitingNCT07589400Phase 11 country
- Sequential PD-1 Antibody and Pegylated Interferon Therapy for Nucleos(t)Ide Analogue-suppressed Chronic Hepatitis BNot yet recruitingNCT07809165Not applicable1 country
- A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (B)RecruitingNCT05771402Phase 21 country
- ASC22 Combined With Peg-IFNa in Achieving Functional Cure in Patients With Chronic Hepatitis B Virus InfectionRecruitingNCT07573943Phase 41 country
- Safety and Efficacy of TAF to Prevent MTCT of HBV in Middle/Late Pregnancies With High HBV DNA LoadRecruitingNCT054660711 country
- Targeting ANKRD11 Reverses HBV-Specific CD8+ T Cell Dysfunction and ToleranceNot yet recruitingNCT07777250
- HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis BNot yet recruitingNCT077803571 country
- Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis BRecruitingNCT06680232Phase 16 countries
- Long-term Follow-up Study to Evaluate Participants With Chronic Hepatitis B (CHB) Previously Treated With AHB-137 InjectionRecruitingNCT071461001 country
- Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)Not yet recruitingNCT07764835
- A Study to Evaluate the Efficacy and Safety of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)RecruitingNCT07137910Phase 21 country
- A Study to Evaluate AHB-137 Injection in Treatment-naïve Participants With Chronic Hepatitis BRecruitingNCT07635186Phase 21 country
- A Multicenter Study of AHB-137 Injection Combined With Other Hepatitis B DrugsRecruitingNCT07069569Phase 21 country
- A Clinical Study Evaluating the Pharmacokinetic Characteristics and Safety of AHB-137 Injection in Participants With Mild to Moderate Liver Dysfunction and Those With Normal Liver Function.RecruitingNCT07600788Phase 11 country
- Sequential PEG-IFN for HBV After Ending RNA-targeted RegimensRecruitingNCT06923280Not applicable1 country
- Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver DiseaseRecruitingNCT028637571 country
- Hepatitis B Infection SurveillanceNot yet recruitingNCT077271871 country
- Phase III Study of HRS-5635 in Nucleos(t)Ide Analogue-suppressed HBeAg-negative Patients With Chronic Hepatitis BRecruitingNCT07606950Phase 31 country
- A Phase I Clinical Study of AHB - 171 in Healthy Participants(HP) and Chronic Hepatitis B (CHB) ParticipantsRecruitingNCT07511218Phase 11 country
- Wearable Patch Ultrasound Probe for Diagnosis of Liver StiffnessNot yet recruitingNCT07716384
- Study of GST-HG131&141 Tablets Compared With Placebo in Patients With Chronic Hepatitis BRecruitingNCT07709520Phase 21 country
- Bepirovirsen Liver Biopsy StudyNot yet recruitingNCT07696520Phase 21 country
- A Study on the Consistency Evaluation of Digital PCR Technology for Quantitative Detection of HBV Nucleic AcidNot yet recruitingNCT076842091 country
- A Trial to Evaluate the Efficacy and Safety of WGc0201 in Patients With Chronic Hepatitis B Virus InfectionRecruitingNCT07051187Phase 11 country
- Clinical Study to Evaluate the Efficacy and Safety of HH-006 in Patients With Chronic Hepatitis B Virus InfectionRecruitingNCT07519330Phase 21 country
- A Phase 1/2, Open-Label, Single and Multiple Ascending Dose Study of CRMA-1001 in Adults With Chronic Hepatitis BRecruitingNCT07200193Phase 1/24 countries
- TherVacB - A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine CandidateRecruitingNCT06513286Phase 1/21 country
- Study of AHB-171 in Chronic Hepatitis B ParticipantsNot yet recruitingNCT07617194Phase 12 countries
- Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell DeregulationRecruitingNCT06853886Not applicable1 country
- Assessment of Treatment Adherence and Associated Factors in Chronic HepB Patients Supported by HBVCareRecruitingNCT07540637Not applicable1 country
- Adaptability of an Undetectable = Untransmissible Model for HBVRecruitingNCT074490911 country
- Phase IIIB Extension Clinical Trial of Efficacy and Safety of GST-HG141 (Nairevir) Combined With NAs in Chronic Hepatitis BNot yet recruitingNCT07588009Phase 3