Interferon Alpha clinical trials
A group of medicines. Interferon alpha-2 (83 studies) and Interferon Alfa-n3 (5 studies) are counted on their own pages; this page counts the studies that name Interferon Alpha itself.
How each study uses Interferon Alpha is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Interferon Alpha studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Medicines filed under Interferon Alpha
As reviewed, so not every one. Each counts its studies on its own page, not here.
Studies by the year they started
52 studies that test it; most in 1995 (6)
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1992 | 1 |
| 1993 | 1 |
| 1994 | 3 |
| 1995 | 6 |
| 1996 | 4 |
| 1997 | 2 |
| 1999 | 3 |
| 2000 | 2 |
| 2002 | 3 |
| 2003 | 3 |
| 2004 | 3 |
| 2005 | 3 |
| 2006 | 2 |
| 2007 | 2 |
| 2008 | 1 |
| 2009 | 2 |
| 2011 | 1 |
| 2012 | 3 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 1 |
| 2017 | 1 |
| 2020 | 1 |
| 2025 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 8 · Other 46
M.D. Anderson Cancer Center (8) · National Cancer Institute (NCI) (4) · Ainos, Inc. (f/k/a Amarillo Biosciences Inc. (4) · Eastern Cooperative Oncology Group (2) · SWOG Cancer Research Network (2) · Kidney Cancer Research Bureau (2) · National Center for Research Resources (NCRR) (2) · Fudan University (2)
Often tested with
Tested in the same studies.
Etoposide (5) · Cyclophosphamide (5) · Cisplatin (5) · Vincristine (3) · Rituximab (2) · Doxorubicin (2) · Filgrastim (2) · Prednisone (2)
Related medicines
As reviewed, each with the page that says it.
- One of Immunologic Factors source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 2 phase 3 studies under way
Interferon Alpha is the comparator. A study of two new drugs counts under both.
- 1Bomedemstat · Merck Sharp & Dohme LLC · next primary completion Jul 2027
- 1Ruxolitinib · University of Birmingham · next primary completion Oct 2028
Studies
Open first, then newest update. How each study uses Interferon Alpha is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 54
- Sequential PEG-IFN for HBV After Ending RNA-targeted RegimensRecruitingNot applicableHuashan HospitalNCT06923280Written as Pegylated Interferon-alpha (IFN)
- Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease ActivityActive, not recruitingPhase 2National Cancer Institute (NCI)NCT00092222Written as Interferon-alpha
- Adjuvant Therapy of Skin Melanoma With Alpha Interferon and NaderinCompletedPhase 2MIPO ClinicNCT07671495Written as interferon alfa
- Interferon-alpha Lozenges for Prevention of Relapse in Hepatitis CCompletedPhase 2Ainos, Inc. (f/k/a Amarillo Biosciences Inc.NCT00695019Written as interferon-alpha lozenges
- Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant MeningiomasCompletedPhase 2M.D. Anderson Cancer CenterNCT00002965Written as Recombinant Interferon Alfa (INF alpha)
- COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;CompletedPhase 3Peter MacCallum Cancer Centre, AustraliaNCT04534725Written as Interferon alfa
- Interferon Alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung CancerCompletedPhase 2Eastern Cooperative Oncology GroupNCT00062010Written as interferon alpha
- Interferon Alfa-2b With or Without Radiation Therapy in Treating Patients With Melanoma That Has Metastasized to Lymph Nodes in the Neck, Under the Arm, or in the GroinCompletedPhase 3Eastern Cooperative Oncology GroupNCT00003444Written as recombinant interferon alfa
- Tretinoin Plus Interferon Alfa in Treating Patients With Metastatic Kidney CancerCompletedPhase 2Weill Medical College of Cornell UniversityNCT00003656Written as recombinant interferon alfa
- Pharmaco-immunological Study of Interferon-alpha and Metronomic Cyclophosphamide Association in Neuroendocrine TumorsCompletedPhase 2Centre Hospitalier Universitaire de BesanconNCT02838342Written as Interferon-alpha
- Interferon-α Prevents Leukemia Relapse of AML Patients After TransplantationWithdrawnNot applicablePeking University People's HospitalNCT03121079Written as Interferon-alpha
- Combination Chemotherapy in Treating Patients With LymphomaCompletedPhase 3M.D. Anderson Cancer CenterNCT00002835Written as Recombinant Interferon Alfa
- Phase II Study Of Roferon and Accutane For Patients With T-Cell MalignanciesCompletedPhase 2M.D. Anderson Cancer CenterNCT00038376Written as Interferon Alpha
- Adjuvant IFN-α for Patients Underwent Curative Surgery for HCC With a Low miR-26 ExpressionStatus unknownPhase 3Fudan UniversityNCT01681446Written as interferon-alpha (IFN-alpha)
- Chemoradiation in Locally Advanced Pancreatic CancerTerminatedPhase 2Masonic Cancer Center, University of MinnesotaNCT00262951Written as recombinant interferon alfa
- Treatment of Follicular Lymphoma With High Dose Therapy and Stem Cell Support Followed by Rituximab and Alpha InterferonCompletedPhase 2Sunnybrook Health Sciences CentreNCT03069248Written as Alpha Interferon
- Interferon for the Intervention of Molecular Relapse in t (8; 21) AML After Allo-HSCTStatus unknownPhase 4Peking University People's HospitalNCT02027064Written as Interferon-alpha
- Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the UrotheliumCompletedPhase 1M.D. Anderson Cancer CenterNCT00082719Written as Recombinant Interferon Alfa
- Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP)CompletedPhase 1Novartis PharmaceuticalsNCT01220648Written as Nilotinib, interferon-alfa
- S9628 Dexamethasone Plus Interferon Alfa in Treating Patients With Primary Systemic AmyloidosisCompletedPhase 2SWOG Cancer Research NetworkNCT00002849Written as recombinant interferon alfa
See all 54 studies that test Interferon Alpha →
Given beside what is tested · 24 — Interferon Alpha is usual care or a partner of the new treatment
- Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple MyelomaCompletedPhase 2City of Hope Medical CenterNCT00004088Written as recombinant interferon alfa
- Interferon and GM-CSF Compared With Imatinib Mesylate and Vaccine Therapy in Patients With Chronic Phase CML on a TKICompletedPhase 2Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT00363649Written as Interferon alfa
- DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCCCompletedPhase 2Dartmouth-Hitchcock Medical CenterNCT00085436Written as recombinant interferon alfa
- Cyclophosphamide and Filgrastim Followed By SCT in Patients With Chronic or Accelerated Phase Myelogenous LeukemiaTerminatedPhase 2Masonic Cancer Center, University of MinnesotaNCT00005984Written as recombinant interferon alfa
- Melphalan, Peripheral Stem Cell Transplantation, and Interleukin-2 Followed by Interferon Alfa in Treating Patients With Advanced Multiple MyelomaCompletedPhase 2Fred Hutchinson Cancer CenterNCT00006244Written as recombinant interferon alfa
- Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-Experienced Genotype 1 Hepatitis C Infected Patients (STARTverso 3)CompletedPhase 3Boehringer IngelheimNCT01358864Written as Pegylated Interferon-alpha (IFN)
- Interferon Alfa-2b With or Without Bevacizumab in Treating Patients With Advanced Renal Cell Carcinoma (Kidney Cancer)CompletedPhase 3Alliance for Clinical Trials in OncologyNCT00072046Written as recombinant interferon alfa
- Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal CancerCompletedPhase 2The Methodist Hospital Research InstituteNCT00445523Written as Interferon-alpha
- Bevacizumab With or Without Interferon Alfa in Treating Patients With Metastatic Malignant MelanomaCompletedPhase 2National Cancer Institute (NCI)NCT00026221Written as Recombinant Interferon Alfa
- Short Term Treatment With BI 201335, Peginterferon-alpha 2a and Ribavirin in Hepatitis c Virus Genotype-1 Treatment-naïve Patients (SILEN-C3)CompletedPhase 2Boehringer IngelheimNCT00984620Written as Pegylated Interferon-alpha (IFN)
- ABR-217620/Naptumomab Estafenatox With Interferon-alpha (IFN-alpha) Compared to IFN-alpha Alone in Patients With Advanced Renal Cell CarcinomaCompletedPhase 2/3Active Biotech ABNCT00420888Written as IFN-alpha
- S0008: Chemotherapy Plus Biological Therapy in Treating Patients With MelanomaCompletedPhase 3SWOG Cancer Research NetworkNCT00006237Written as interferon alfa
- SWOG-9321 Melphalan, TBI, and Transplant vs Combo Chemo in Untreated MyelomaCompletedPhase 3SWOG Cancer Research NetworkNCT00002548Written as recombinant interferon alfa
- S9805, High-Dose Melphalan Plus Peripheral Stem Cell Transplantation Followed by Interferon Alfa in Treating Patients With Waldenstrom's MacroglobulinemiaCompletedPhase 2SWOG Cancer Research NetworkNCT00003416Written as recombinant interferon alfa
- Safety and Efficacy of Imatinib Versus Interferon-α Plus Cytarabine in Patients With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous LeukemiaCompletedPhase 3Novartis PharmaceuticalsNCT00333840Written as interferon-alpha (INF-a)
- Sorafenib and Interferon Alfa in Treating Patients With Locally Advanced or Metastatic Kidney CancerTerminatedPhase 2National Cancer Institute (NCI)NCT00098618Written as recombinant interferon alfa
- Interleukin-12 and Interferon Alfa in Treating Patients With Metastatic Malignant MelanomaCompletedPhase 2National Cancer Institute (NCI)NCT00026143Written as recombinant interferon alfa
- Interleukin-12 and Interferon Alfa in Treating Patients With Metastatic Kidney Cancer or Malignant MelanomaCompletedPhase 1National Cancer Institute (NCI)NCT00004244Written as recombinant interferon alfa
- Thalidomide Plus Interferon Alfa in Treating Patients With Progressive Liver Cancer That Cannot be Surgically RemovedCompletedPhase 2National Cancer Institute (NCI)NCT00006006Written as recombinant interferon alfa
- Radiolabeled Monoclonal Antibody, Paclitaxel, and Interferon Alfa in Treating Patients With Recurrent Ovarian CancerCompletedPhase 1National Cancer Institute (NCI)NCT00002734Written as recombinant interferon alfa
Showing 20 of 24.
As the comparator · 7 — what is tested is compared with Interferon Alpha
- MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia VeraRecruitingPhase 3University of BirminghamNCT04116502Written as Interferon-Alpha
- A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT06079879Written as Interferon alfa/pegylated interferon alfa 2a/pegylated interferon alfa 2b
- Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCLStatus unknownPhase 3European Mantle Cell Lymphoma NetworkNCT00209209Written as Interferon-alpha
- SU011248 Versus Interferon-Alfa As First-Line Systemic Therapy For Patients With Metastatic Renal Cell CarcinomaCompletedPhase 3PfizerNCT00083889Written as Interferon-alfa
- Trial of Thalidomide, a- Interferon +/- Octreotide in Patients With Unresectable Hepatocellular CarcinomaCompletedPhase 2University of New MexicoNCT00250796Written as Thalidomide, alpha interferon
- Maintenance Therapy After Thalidomide-Dexamethasone(ThaDD) for Multiple Myeloma(MM)CompletedPhase 3Università Politecnica delle MarcheNCT00633542Written as interferon alpha
- Safety Study of Low Dose Interleukin 2 (IL-2) Plus PEG-IFN/RBV In Chronic Hepatitis C Virus Genotype ITerminatedPhase 1Weill Medical College of Cornell UniversityNCT00277758Written as Pegylated Interferon Alpha
Codes
What other systems call Interferon Alpha · ClinicalTrials.gg INT008551
- MeSH (NLM) D016898Interferon-alphaOne source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D016898 | Interferon-alpha | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.