Hydroxymethylglutaryl-CoA Reductase Inhibitors: all 1,670 studies that test it

Page 2 of 17. Open to participants first (137), then studies with results posted, then the rest; newest registration first within each.

• Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)Not yet recruitingNCT05587621Not applicable
• T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate CancerRecruitingNCT05586360Phase 2
• Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 TargetedRecruitingNCT05559164Phase 2
• The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast CancerRecruitingNCT05550415Phase 2
• Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)RecruitingNCT05483010Phase 2
• Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast CancerRecruitingNCT05464810Early Phase 1
• Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)RecruitingNCT05404139Phase 2
• Vascular Endothelial Dysfunction in Sleep ApneaRecruitingNCT05289063Phase 1
• Blood Pressure and Lipids Reduction in High Risk Elderly Patients With Isolated Systolic HypertensionRecruitingNCT05165251Phase 4
• Statin Therapy With Atorvastatin in Surgical Aortic Valve ReplacementRecruitingNCT05076019Not applicable
• Endometriosis and Microvascular Dysfunction; Simvastatin and DuaveeEnrolling by invitationNCT05059626Phase 4
• A Randomized Clinical Trial to Evaluate the Effects of Atorvastatin on Graves' Orbitopathy (GO): the STAGO-2 StudyNot yet recruitingNCT05049603Phase 3
• Cross-over Study of Coronary Risk Factors With a PolypillRecruitingNCT05030818Phase 4
• Safety and Efficacy of Atorvastatin v. Placebo on HCC RiskRecruitingNCT05028829Phase 2
• Efficacy of Simvastatin in Alcoholic Liver FibrosisRecruitingNCT04971577Phase 2/3
• Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck CancerRecruitingNCT04915183Phase 2
• Liver Adiposity Effects on Pediatric StatinRecruitingNCT04903223Phase 1
• Statin for Neuroprotection in Spontaneous Intracerebral HemorrhageRecruitingNCT04857632Phase 2/3
• Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall FibrosisRecruitingNCT04833764Phase 1/2
• Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)RecruitingNCT04765137Phase 2
• Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMDRecruitingNCT04735263Phase 2
• Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)RecruitingNCT04699279Not applicable
• The MASTER Study (MAmmary Cancer STatin ER Positive Study)RecruitingNCT04601116Phase 3
• Assessment of the Effects of Long-term Lipid-lowering Therapy in Patients With Primary STEMI or NSTEMIRecruitingNCT04347434Phase 4
• Statins for Venous Event Reduction in Patients With Venous ThromboembolismRecruitingNCT04319627Phase 3
• Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older AdultsRecruitingNCT04262206Phase 4
• Peri-vascular Adipose Tissue Inflammation Evaluated Using Coronary CT AngiographyRecruitingNCT04181749Phase 2
• Atorvastatin to Reduce Inflammation After Tuberculosis Treatment CompletionRecruitingNCT04147286Phase 2/3
• Impact of Atorvastatin on Prostate Cancer Progression During ADTRecruitingNCT04026230Phase 3
• Statins In Intracerbral HemorrhageRecruitingNCT03936361Phase 3
• Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate CancerRecruitingNCT03819101Phase 3
• Statins and ARBs on Rheumatoid ActivityRecruitingNCT03770702Phase 3
• Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)RecruitingNCT03571802Phase 4
• Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)RecruitingNCT03131726Phase 3
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaRecruitingNCT02735707Phase 3
• The Efficacy and Safety of Combined Therapy With Red Yeast Rice and Low-dose Statin：Comparing With Standardized StatinRecruitingNCT02726555Phase 3
• Myocardial Protection Effect of Simvastatin Undergoing Cardiac SurgeryRecruitingNCT01653223Not applicable
• A Study to Assess the Effect of Ceftobiprole on the PK of Pitavastatin and on Plasma Levels of CoproporphyrinCompletedNCT06808646Phase 1Results posted
• A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the BloodCompletedNCT06504862Phase 1Results posted
• A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese ParticipantsCompletedNCT06186622Phase 1Results posted
• Systems Biological Assessment of Statin Effect on Vaccine ResponsesCompletedNCT06024096Phase 4Results posted
• A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy ParticipantsCompletedNCT05906836Phase 1Results posted
• A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult ParticipantsTerminatedNCT05788328Phase 1Results posted
• EMERALD (Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders)CompletedNCT05742841Phase 4Results posted
• A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver CirrhosisCompletedNCT05741372Not applicableResults posted
• MicroRNA Activation of LOX-1 Mechanisms in EndometriosisTerminatedNCT05331053Phase 4Results posted
• A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy ParticipantsCompletedNCT05176314Phase 1Results posted
• STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTSCompletedNCT05093205Phase 1Results posted
• Drug-Drug Interaction Study of Evobrutinib and Transporter SubstratesCompletedNCT05064488Phase 1Results posted
• Supplements, Placebo, or Rosuvastatin StudyCompletedNCT04846231Phase 2Results posted
• A Study of Lasmiditan in Healthy VolunteersCompletedNCT04749914Phase 1Results posted
• Pilot Study of Atorvastatin and Anakinra in Children With Coronary Artery Abnormalities Secondary to Kawasaki DiseaseCompletedNCT04747847Early Phase 1Results posted
• Anti-inflammatory Effects of SimvastatinTerminatedNCT04638400Phase 4Results posted
• A Study in Healthy People to Test Whether BI 730357 Affects How 4 Other Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Taken up in the BodyCompletedNCT04590937Phase 1Results posted
• 7 Tesla MRI Study in Patients With Statin Related Muscle ComplaintsCompletedNCT04575090Not applicableResults posted
• 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle EventsTerminatedNCT04507373Phase 4Results posted
• Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy AdultsCompletedNCT04425902Phase 1Results posted
• CHOlesterol Lowering and Residual Risk in Type 2 DiabetesCompletedNCT04369664Phase 4Results posted
• DSAP Treatment Comparison: 2% Lovastatin/ 2% Cholesterol vs 2% Lovastatin AloneCompletedNCT04359823Phase 1Results posted
• A Study of LY3478045 in Healthy ParticipantsCompletedNCT04270370Phase 1Results posted
• A Study in Healthy Men to Test the Influence of BI 1323495 on the Amount of the Medicines Rosuvastatin and Dabigatran in the BloodCompletedNCT04257032Phase 1Results posted
• Investigation of the Gut Microbiome and Statin ResponseCompletedNCT04098003Phase 4Results posted
• Drug-Drug Interaction Between Rifampin and FluvastatinCompletedNCT04029584Phase 4Results posted
• Pravastatin to Prevent PreeclampsiaTerminatedNCT03944512Phase 3Results posted
• Simvastatin in Secondary Progressive Multiple SclerosisCompletedNCT03896217Phase 2Results posted
• StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With TuberculosisCompletedNCT03882177Phase 2Results posted
• Atorvastatin in Treating Patients With Stage IIb-III Triple Negative Breast Cancer Who Did Not Achieve a Pathologic Complete Response After Receiving Neoadjuvant ChemotherapyTerminatedNCT03872388Phase 2Results posted
• Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate CancerCompletedNCT03830164Phase 2Results posted
• A Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy VolunteersCompletedNCT03717064Phase 1Results posted
• Dose-ranging Efficacy and Pharmacokinetics Study of Intravenous Atorvastatin in Hypercholesterolemic PatientsCompletedNCT03611010Phase 2Results posted
• Pilot Study of Rosuvastatin and Enoxaparin Thromboprophylaxis Following Ovarian Cancer Surgery (O-STAT Study)CompletedNCT03532139Phase 2Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT03510884Phase 3Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT03510715Phase 3Results posted
• Statin Adjunctive Therapy for TBCompletedNCT03456102Phase 2Results posted
• The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast CancerCompletedNCT03454529Phase 2Results posted
• Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance PatientsCompletedNCT03452891Phase 4Results posted
• Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant MucositisCompletedNCT03400475Phase 2Results posted
• Impact of Statin Therapy on Adaptations to Aerobic ExerciseCompletedNCT03360916Phase 4Results posted
• Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic CapacityCompletedNCT03351998Phase 4Results posted
• Pharmacokinetics of Midazolam, Dabigatran, Pitavastatin, Atorvastatin, and Rosuvastatin in Participants With Renal Insufficiency in the Presence and Absence of Rifampin (MK-0000-386)CompletedNCT03311841Phase 1Results posted
• This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy MenCompletedNCT03307252Phase 1Results posted
• Pravastatin Intervention to Delay Hepatocellular Carcinoma RecurrenceTerminatedNCT03219372Phase 2Results posted
• PREPARE (A5361s) Ancillary Study of REPRIEVE (A5332)CompletedNCT03070223Phase 3Results posted
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-CCompletedNCT03051100Phase 2Results posted
• A Study of Lanabecestat (LY3314814) in Healthy Participants When Taken With RosuvastatinCompletedNCT03019549Phase 1Results posted
• Neurophysiological and Acute Pharmacological Studies in FXS PatientsCompletedNCT02998151Early Phase 1Results posted
• Simvastatin in Preventing Liver Cancer in Patients With Liver CirrhosisCompletedNCT02968810Phase 2Results posted
• STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)CompletedNCT02943590Phase 2Results posted
• STAT-STatin and Aspirin in TraumaTerminatedNCT02901067Phase 2Results posted
• An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT02890992Phase 2Results posted
• Transporter Cocktail Mutual InteractionCompletedNCT02854527Phase 1Results posted
• Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and OutcomesTerminatedNCT02850081Phase 3Results posted
• High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIVCompletedNCT02841774Phase 2Results posted
• A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)CompletedNCT02748057Phase 3Results posted
• Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic PancreatitisCompletedNCT02743364Phase 2Results posted
• A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)CompletedNCT02741245Phase 3Results posted
• CT COMPARE: CT Coronary Angiography to Measure Plaque ReductionTerminatedNCT02740699Phase 4Results posted
• A Study to Evaluate LY3202328 in Overweight Healthy Participants and DyslipidemiaCompletedNCT02714569Phase 1Results posted
• A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Fimasartan and Rosuvastatin in Healthy Male SubjectsCompletedNCT02704702Phase 1Results posted
• STOP Heart Disease in Breast Cancer Survivors TrialTerminatedNCT02674204Phase 2Results posted

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