Drug
Folfox protocol clinical trials
- studies test it
- 84
- open now
- 29
- in phase 3
- 16
- first study started
- 2004
Keep track of what changes. Save the Folfox protocol studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
83 studies that test it; most in 2009 (9)
| Year | Studies |
|---|---|
| 2004 | 1 |
| 2005 | 2 |
| 2006 | 3 |
| 2007 | 3 |
| 2008 | 1 |
| 2009 | 9 |
| 2010 | 4 |
| 2011 | 1 |
| 2012 | 3 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 3 |
| 2016 | 3 |
| 2017 | 3 |
| 2018 | 9 |
| 2019 | 2 |
| 2020 | 4 |
| 2021 | 5 |
| 2022 | 3 |
| 2023 | 3 |
| 2024 | 6 |
| 2025 | 8 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 3
- Phase 1
- 18
- Phase 2
- 52
- Phase 3
- 16
- No phase
- 4
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 16 · Other 68
Sun Yat-sen University (8) · GERCOR - Multidisciplinary Oncology Cooperative Group (2) · Washington University School of Medicine (2) · Canadian Cancer Trials Group (2) · Genentech, Inc. (2) · Yonsei University (2) · AstraZeneca (2) · Sixth Affiliated Hospital, Sun Yat-sen University (2)
Often tested with
Tested in the same studies.
FOLFIRI Regimen (18) · FOLFIRI-Ziv-aflibercept Regimen (17) · Bevacizumab (17) · Cetuximab (6) · Panitumumab (5) · CAPOX Regimen (5) · Fluorouracil (5) · Capecitabine (4)
Studies
Open first, then newest update. How each study uses Folfox protocol is read from its arms, and is right about nine times in ten.
Testing it · 84
- A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid TumorsRecruitingPhase 1/2Merus B.V.NCT03526835Written as MCLA-158 + FOLFOX
- ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal CancerRecruitingEarly Phase 1M.D. Anderson Cancer CenterNCT07318389Written as FOLFOX
- A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)RecruitingPhase 1Hoffmann-La RocheNCT04929223Written as FOLFOX
- Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal AdenocarcinomaRecruitingPhase 2Duke UniversityNCT07603375Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II TrialRecruitingPhase 2Shanghai Pudong HospitalNCT07106034Written as Ongericimab + Toripalimab + Bevacizumab + FOLFOX
- Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Colorectal Liver MetastasisRecruitingEarly Phase 1Northwell HealthNCT07193862Written as Doxorubicin, FOLFOX, Botensilimab, Balstilimab, Bevacizumab, FOLFIRI, FOLFIRINOX, AGEN2373
- TAIC FOLFOX for Locally Advanced G/GEJARecruitingPhase 2Guang'anmen Hospital of China Academy of Chinese Medical SciencesNCT07655024Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon CancerRecruitingPhase 3Maimónides Biomedical Research Institute of CórdobaNCT06783491Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction AdenocarcinomaRecruitingPhase 2AstraZenecaNCT05702229Written as FOLFOX
- Randomized Study of Plasma ctDNA Methylation to Guide Adjuvant Chemotherapy Decisions in High-Risk T3N0 Colorectal CancerRecruitingPhase 2Fudan UniversityNCT07562711Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Dose Individualization of Chemotherapy in Patients With Gastrointestinal Cancers Lacking a Specific Liver EnzymeRecruitingPhase 2UNICANCERNCT06475352Written as FOLFOX regimen
- Sequential FOLFOX-HAIC-TACE Plus Sintilimab-Bevacizumab Neoadjuvant Therapy Versus Direct Resection in Resectable High-Risk Recurrence Hepatocellular CarcinomaNot yet recruitingPhase 1/2BinYong LiangNCT07522411Written as FOLFOX regimen
- Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial)RecruitingPhase 1University of California, IrvineNCT05733689Written as FOLFOX
- FOLFOX-HAIC Combined With Donafenib and Pucotenlimab as First-Line Treatment for Unresectable Intrahepatic CholangiocarcinomaNot yet recruitingPhase 2Sun Yat-sen UniversityNCT07353827Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Folfox+Irinotecan+Chemort In Esophageal CancerRecruitingPhase 2Massachusetts General HospitalNCT04656041Written as FOLFOX/ nal-IRI
- The Phase 1b/IIa, Open-label, Dose Escalation and Dose Expansion to Evaluate Safety, Tolerability, and Preliminary Efficacy of the Combination of HCB101, Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in Advanced or Metastatic Colorectal CancerRecruitingPhase 1/2Chang Gung Memorial HospitalNCT07204574Written as FOLFOX (Oxaliplatin/Leucovorin/5-Fluorouracil)
- Systemic Chemotherapy With FOLFOX Plus Atezolizumab & Bevacizumab for Patients With Advanced HCC Who Previously Received Atezolizumab & BevacizumabRecruitingPhase 2Sun Yat-sen UniversityNCT07192185Written as FOLFOX
- Thalidomide Enhances Clinical Efficacy of Cetuximab Combined With Standard Chemotherapy for Left Colorectal CancerRecruitingPhase 2Xinqiao Hospital of ChongqingNCT06279351Written as Thalidomide+cetuximab+FOLFOX/FOLFIRI
- Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)RecruitingPhase 2Neil KopekNCT06991465Written as FOLFOX regimen
- Personalising and Refining Neo-adjuvant Chemotherapy in Locally Advanced but Resecable Colon Cancer in the Elderly of 70 Years Old or MoreRecruitingPhase 3Centre Hospitalier Universitaire DijonNCT06293625Written as Folfox
See all 84 studies that test Folfox protocol →
Given in every arm · 68 — Folfox protocol is usual care beside what is tested
- A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal CancerRecruitingPhase 2/3Bristol-Myers SquibbNCT07221357Written as FOLFOX
- CR-001 in Adult Participants With Locally Advanced or Metastatic Solid TumorsRecruitingPhase 1/2Crescent Biopharma, Inc.NCT07335497Written as FOLFOX
- A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal CancerRecruitingPhase 3Incyte CorporationNCT07284849Written as FOLFOX
- A Study of PHST001 in Advanced Solid TumorsRecruitingPhase 1Pheast TherapeuticsNCT06840886Written as FOLFOX
- Open-Label Study of BBO-10203 in Subjects With Advanced Solid TumorsRecruitingPhase 1TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)NCT06625775Written as FOLFOX
- A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)RecruitingPhase 2/3Bristol-Myers SquibbNCT07221149Written as Folfox
- Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)RecruitingPhase 1/2Phanes TherapeuticsNCT05482893Written as FOLFOX
- A Study of JNJ-89402638 for Metastatic Colorectal and Gastric CancersRecruitingPhase 1Janssen Research & Development, LLCNCT06663319Written as FOLFOX
- A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.RecruitingPhase 2Weill Medical College of Cornell UniversityNCT05024097Written as FOLFOX regimen
- A Clinical Trial to Evaluate the Safety, Tolerability and Clinical Efficacy of M3T01 Monotherapy and in Combination With Pembrolizumab and Other Systemic TherapiesRecruitingPhase 1Providence Health & ServicesNCT06719362Written as FOLFOX regimen
- A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid TumorsRecruitingPhase 1Incyte CorporationNCT05836324Written as FOLFOX
- A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D MutationRecruitingPhase 1Incyte CorporationNCT06179160Written as FOLFOX
- KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal CancerNot yet recruitingPhase 2Gustave Roussy, Cancer Campus, Grand ParisNCT07622017Written as FOLFOX
- A Study to Determine the Effect of CT3001 in Patients With Advanced Solid TumorsRecruitingPhase 1/2Crossignal Therapeutics, Inc.NCT06598007Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal AdenocarcinomaRecruitingPhase 2UNICANCERNCT06846346Written as FOLFOX regimen
- MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal CancerRecruitingPhase 1Medical College of WisconsinNCT04808323Written as FOLFOX
- Continuation of Cetuximab Beyond First-Line Progression in Metastatic Colorectal CancerRecruitingPhase 3University of Campania Luigi VanvitelliNCT07389265Written as FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin)
- Immune Checkpoint Inhibitors + Chemotherapy Versus Chemotherapy in the Neoadjuvant Treatment of Locally Advanced Colorectal CancerRecruitingPhase 2Cancer Institute and Hospital, Chinese Academy of Medical SciencesNCT06154538Written as FOLFOX regimen
- First-line EXL01 With Nivolumab and FOLFOX for PD-L1 CPS ≥5 Metastatic Gastric CancerRecruitingPhase 2GERCOR - Multidisciplinary Oncology Cooperative GroupNCT06253611Written as FOLFOX regimen
- Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal CancerNot yet recruitingPhase 3Zhejiang Cancer HospitalNCT07074353Written as FOLFOX
Showing 20 of 68.
As the comparator · 28 — what is tested is compared with Folfox protocol
- Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal CancerRecruitingPhase 3J. W. A. BurgerNCT07472868Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- XS-03 in Combination With FOLFOX or FOLFIRI and Bevacizumab for Treatment of Metastatic Colorectal Cancer Patients With RAS MutationEnrolling by invitationPhase 1/2Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.NCT06936527Written as Biological: Bevacizumab, Drug: FOLFOX, Drug: FOLFIRI
- Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer PatientsRecruitingPhase 2UNICANCERNCT06529718Written as FOLFOX regimen
- Paclitaxel, Ramucirumab and Tislelizumab Switch Maintenance in Advanced HER2-negative and PD-L1 TAP Score of 5 or More Advanced Gastroesophageal AdenocarcinomaNot yet recruitingPhase 3Gruppo Oncologico del Nord-OvestNCT07763171Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric AdenocarcinomasRecruitingPhase 3Centre Leon BerardNCT06346197Written as Folfox Protocol
- A Randomized Controlled Trial of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy Decision-Making in High-Risk Stage III (T4N+ or T1-3N2) Colorectal CancerRecruitingPhase 2Fudan UniversityNCT07562490Written as FOLFOX
- Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon CancerRecruitingPhase 3GlaxoSmithKlineNCT05855200Written as FOLFOX
- NALIRIFOX Plus Targeted Therapy Versus FOLFOX Plus Targeted Therapy as First-line Treatment for Metastatic Colorectal CancerRecruitingPhase 3Shanghai Zhongshan HospitalNCT07309289Written as FOLFOX plus targeted therapy
- Efficacy and Safety of FOLFOX+Cetuximab vs. FOLFOXIRI+Bevacizumab Both With QL1706 in First-Line Treatment of Left-Sided mCRCNot yet recruitingPhase 2Fujian Cancer HospitalNCT07070713Written as FOLFOX+QL1706+Cetuximab
- Oncolytic Virus H101 Combined With Lenvatinib Plus Toripalimab Compared With FOLFOX in Patients With Advanced Biliary Tract Cancer (OPTIONS-06)Not yet recruitingPhase 2Fudan UniversityNCT06919848Written as FOLFOX
- Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01)RecruitingPhase 2Fudan UniversityNCT06860477Written as FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Anlotinib Plus Nab-Paclitaxels and S-1 for Patients with Advanced Biliary Tract Cancer As Second-Line TreatmentNot yet recruitingPhase 2/3Sun Yat-sen UniversityNCT06662877Written as Oxaliplatin + Leucovorin + Fluorouracil (FOLFOX regimen)
- Second Line Therapy for Advanced Intrahepatic CholangiocarcinomaNot yet recruitingPhase 2Tianjin Medical University Cancer Institute and HospitalNCT05535647Written as FOLFOX
- Mebendazole as Adjuvant Treatment for Colon CancerRecruitingPhase 3Sherief Abd-ElsalamNCT03925662Written as Folfox with avastin
- Oxaliplatin ± Nivolumab in Combination With Trifluridine/Tipiracil or 5-fluorouracile in Frail Patients With Advanced, Recurrent or Metastatic Gastric, Oesophageal or Gastroesophageal Junction CancerActive, not recruitingPhase 2UNICANCERNCT05476796Written as FOLFOX regimen
- Personalizing Chemotherapy Selection After Surgery for Patients With Stage III Colorectal Cancer Using a Blood TestActive, not recruitingPhase 3UNICANCERNCT07340567Written as FOLFOX regimen
- PReoperative Chemoradiation (Paclitaxel-carboplatin or FOLFOX) for Resectable Esophageal and Junctional CancerCompletedPhase 2Centre Oscar LambretNCT02359968Written as FOLFOX
- Immunotherapy for Advanced Liver CancerSuspendedPhase 2/3Mirror Biologics, Inc.NCT05033522Written as FOLFOX regimen
- Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSEActive, not recruitingPhase 3ITM Solucin GmbHNCT04919226Written as FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin)
- Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic CancerCompletedPhase 2Federation Francophone de Cancerologie DigestiveNCT03186326Written as FOLFOX regimen
Showing 20 of 28.