Drug
Doravirine clinical trials
Also written MK-1439, Pifeltro and MK-1439A.
- studies test it
- 41
- open now
- 8
- in phase 3
- 12
- first study started
- 2011
Keep track of what changes. Save the doravirine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Combined with it in one product
- MK-8591A
- 10
Studies by the year they started
41 studies that test it; most in 2020 (8)
| Year | Studies |
|---|---|
| 2011 | 1 |
| 2012 | 1 |
| 2014 | 1 |
| 2015 | 4 |
| 2016 | 2 |
| 2017 | 1 |
| 2018 | 1 |
| 2019 | 2 |
| 2020 | 8 |
| 2021 | 4 |
| 2022 | 3 |
| 2023 | 6 |
| 2024 | 2 |
| 2025 | 3 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 11
- Phase 2
- 10
- Phase 3
- 12
- Phase 4
- 8
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 21 · Other 20
Merck Sharp & Dohme LLC (21) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (3) · Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida (2) · Fundacion Clinic per a la Recerca Biomédica (1) · University of North Carolina, Chapel Hill (1) · Radboud University Medical Center (1) · University of Texas Southwestern Medical Center (1) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (1)
Often tested with
Tested in the same studies.
Islatravir (11) · Lamivudine (8) · Tenofovir (7) · Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (2) · Bictegravir, emtricitabine, tenofovir alafenamide, drug combination (1) · Spironolactone (1) · Estradiol (1) · Rifapentine (1)
Studies
Open first, then newest update. How each study uses doravirine is read from its arms, and is right about nine times in ten.
Testing it · 41
- DOR/ISL in Pediatric Participants With HIV-1, <18 Years of Age and ≥ 35 kgNot yet recruitingPhase 2Merck Sharp & Dohme LLCNCT07862569Written as DOR/ISL
- Efficacy and Safety of Doravirine in the Rapid InitiationRecruitingPhase 4Fundación HuéspedNCT07357584Written as Doravirine / lamivudine/ Tenofovir Disoproxil Oral Tablet
- DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 InfectionRecruitingPhase 3ANRS, Emerging Infectious DiseasesNCT06203132Written as Doravirine + tenofovir DF + lamivudine
- Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)RecruitingPhase 2Merck Sharp & Dohme LLCNCT04375800Written as Doravirine
- Doravirine Dose Optimisation in PregnancyRecruitingPhase 4University of LiverpoolNCT05630638Written as Doravirine
- Doravirine/Lamivudine (DOR/3TC) as a Maintenance ART in Comparison With Dolutegravir/Lamivudine (DTG/3TC) in PLWH SuccessfullyRecruitingPhase 2Centre de Recherches et d'Etude sur la Pathologie Tropicale et le SidaNCT06774872Written as Doravirine 100Mg Tab and Lamivudine 300 Mg Tab
- HIV-1 Infected Patients, Phase II Trial, Dual Combination Doravirine/Raltegravir Open LabelRecruitingPhase 2Centre de Recherches et d'Etude sur la Pathologie Tropicale et le SidaNCT04513626Written as DORAVIRINE 100 MG [Pifeltro]
- Change in Body Weight and BMI in PWH with DOR/3TC/TDF Compared with INSTIRecruitingPhase 4Instituto Mexicano del Seguro SocialNCT06602622Written as Doravirine + tenofovir DF + lamivudine
- DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05705349Written as DOR/ISL
- Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)CompletedPhase 3Merck Sharp & Dohme LLCNCT04233879Written as DOR/ISL
- Single Dose Pharmacokinetics of Doravirine in HIV-infected Pregnant WomenCompletedPhase 1University of North Carolina, Chapel HillNCT04900974Written as Doravirine
- Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding VolunteersCompletedPhase 4Radboud University Medical CenterNCT05648201Written as Doravirine 100Mg Tab
- Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018)CompletedPhase 3Merck Sharp & Dohme LLCNCT04223791Written as DOR/ISL
- A Study of Doravirine/Islatravir in Healthy Lactating Females (MK-8591A-061)CompletedPhase 1Merck Sharp & Dohme LLCNCT07086079Written as DOR/ISL
- Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIVCompletedEarly Phase 1University of Texas Southwestern Medical CenterNCT04820933Written as Doravirine 100 Mg
- A Study of Doravirine/Islatravir (DOR/ISL, MK-8591A) for the Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection in Participants Who Previously Received DOR/ISL (MK-8591A-054)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05766501Written as DOR/ISL
- A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05631093Written as DOR/ISL
- A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-052)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05630755Written as DOR/ISL
- Doravirine for Obese Persons on Integrase Inhibitors and Tenofovir AlafenamideCompletedPhase 4Advancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsNCT04636437Written as Doravirine 100 Mg
- Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender WomenCompletedPhase 1Thomas Jefferson UniversityNCT04283656Written as Doravirine/Lamivudine/Tenofovir
See all 41 studies that test doravirine →
Given in every arm · 4 — doravirine is usual care beside what is tested
- Efficacy of Doravirine + Dolutegravir Dual Therapy in the Context of Antiretroviral Therapy SwitchRecruitingPhase 3Chelsea and Westminster NHS Foundation TrustNCT04892654Written as Doravirine
- Safety and Efficacy of a Switch to Doravirine/Islatravir in Participants With HIV-1 (MK-8591A-017)CompletedPhase 3Merck Sharp & Dohme LLCNCT04223778Written as DOR/ISL
- A Study of Doravirine and Islatravir as a Single Entity or Combination Therapy and the Effect of Food in Healthy Adult Participants (MK-8591A-055)CompletedPhase 1Merck Sharp & Dohme LLCNCT06719570Written as Doravine
- Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018)CompletedPhase 3Merck Sharp & Dohme LLCNCT02275780Written as Doravirine
Codes
What other systems call doravirine · ClinicalTrials.gg INT000104
- MeSH (NLM) C000592662doravirineOne source NLM
- UNII (FDA) 913P6LK81MDORAVIRINEConfirmed FDA, NLM, Wikidata
- RxNorm 2055755Confirmed FDA, Wikidata
- Wikidata Q6885419doravirineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C171848DoravirineOne source FDA
- DrugBank DB12301One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000592662 | doravirine | One source NLM |
| UNII (FDA) | 913P6LK81M | DORAVIRINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2055755 | — | Confirmed FDA, Wikidata |
| Wikidata | Q6885419 | doravirine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C171848 | Doravirine | One source FDA |
| DrugBank | DB12301 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.