Drug
Defibrotide clinical trials
Also written Defitelio®.
- studies test it
- 20
- open now
- 3
- in phase 3
- 4
- first study started
- 2000
Keep track of what changes. Save the defibrotide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Brand
Studies by the year they started
20 studies that test it; most in 2018 (3)
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2005 | 1 |
| 2006 | 2 |
| 2007 | 1 |
| 2016 | 1 |
| 2017 | 2 |
| 2018 | 3 |
| 2019 | 1 |
| 2020 | 3 |
| 2021 | 3 |
| 2024 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 2
- Phase 2
- 15
- Phase 3
- 4
- Phase 4
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 5 · Other 15
Jazz Pharmaceuticals (5) · New York Medical College (4) · University of California, San Francisco (2) · Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia (1) · Gregory Yanik (1) · IRCCS San Raffaele (1) · Bernd Jilma (1) · Dana-Farber Cancer Institute (1)
Often tested with
Tested in the same studies.
Studies
Open first, then newest update. How each study uses defibrotide is read from its arms, and is right about nine times in ten.
Testing it · 20
- Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell DiseaseRecruitingPhase 2New York Medical CollegeNCT02675959Written as Defibrotide
- Defibrotide for the Treatment of Severe COVID-19RecruitingPhase 2Brigham and Women's HospitalNCT04652115Written as Defibrotide
- Defibrotide Dose-escalation for SOS Post-HSCTRecruitingPhase 2New York Medical CollegeNCT05987124Written as Defibrotide
- Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for NeuroblastomaWithdrawnPhase 2University of California, San FranciscoNCT06182410Written as Defibrotide
- Defibrotide in Sickle Cell Disease-Related Acute Chest SyndromeCompletedPhase 2New York Medical CollegeNCT03805581Written as Defibrotide
- Defibrotide in Children With High Risk Kawasaki DiseaseActive, not recruitingPhase 2New York Medical CollegeNCT04777422Written as Defibrotide
- Defibrotide as Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome of Covid 19.CompletedPhase 2Fundacion para la Formacion e Investigacion Sanitarias de la Region de MurciaNCT04348383Written as Defibrotide
- Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)CompletedPhase 1Gregory YanikNCT04530604Written as Defibrotide
- Defibrotide in COVID-19 PneumoniaCompletedPhase 2IRCCS San RaffaeleNCT04335201Written as Defibrotide Injection
- Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric PatientsCompletedPhase 3Jazz PharmaceuticalsNCT02851407Written as Defibrotide
- A Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated NeurotoxicityTerminatedPhase 2Jazz PharmaceuticalsNCT03954106Written as Defibrotide
- Defibrotide TMA Prophylaxis Pilot TrialCompletedPhase 2University of California, San FranciscoNCT03384693Written as Defibrotide
- An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD)CompletedPhase 2Jazz PharmaceuticalsNCT03339297Written as Defibrotide
- 5-day Defibrotide Treatment for Hepatic SOS/VODStatus unknownPhase 2Loyola UniversityNCT04313036Written as Defibrotide
- Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of DefibrotideCompletedPhase 4Bernd JilmaNCT02876601Written as Defibrotide
- Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND StudyCompletedPhase 3Jazz PharmaceuticalsNCT00628498Written as Defibrotide
- Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant PatientsCompletedPhase 3Jazz PharmaceuticalsNCT00358501Written as Defibrotide
- Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell TransplantationCompletedPhase 2Dana-Farber Cancer InstituteNCT00003966Written as defibrotide
- Melphalan, Prednisone, Thalidomide and Defibrotide in Relapsed Multiple Myeloma PatientsCompletedPhase 1/2Silvio AimeNCT00406978Written as Defibrotide
- Pediatric Trial Investigating the Incidence & Outcome of Veno-Occlusive Disease With the Prophylactic Use of DefibrotideCompletedPhase 2/3European Society for Blood and Marrow TransplantationNCT00272948Written as Defibrotide
Codes
What other systems call defibrotide · ClinicalTrials.gg INT003069
- MeSH (NLM) C036901defibrotideConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 438HCF2X0MDEFIBROTIDE (BOVINE)Confirmed FDA, NLM
- RxNorm 1788946One source FDA
- NCI Thesaurus C155982Defibrotide (Bovine)One source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C036901 | defibrotide | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 438HCF2X0M | DEFIBROTIDE (BOVINE) | Confirmed FDA, NLM |
| RxNorm | 1788946 | — | One source FDA |
| NCI Thesaurus | C155982 | Defibrotide (Bovine) | One source FDA |
Also registered as defibrotide sodium (UNII L7CHH2B2J0 · RxNorm 1311089).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.