Acute Chest Syndrome clinical trials
The registry lists 40 studies for Acute Chest Syndrome across 7 countries. 11 are recruiting or about to start. 27 of them are mainly about Acute Chest Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
Assistance Publique - Hôpitaux de Paris (11) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Centre Hospitalier Intercommunal Creteil (1) · University Hospital, Tours (1) · AstraZeneca (1) · Soutien aux Actions contre les Maladies du Globule Rouge (1) · Vanderbilt University (1) · CSL Behring (1)
What is being tested here
Drugs under test in Acute Chest Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Apr 2027Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Dec 2026Tocilizumab for Acute Chest Syndrome · University of Chicago
- Oct 2027Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis · CSL Behring
Who these studies take
Of the 7 Acute Chest Syndrome studies recruiting now, 5 (71%) set no upper age limit and 1 (14%) stop at 75 or younger. 5 (71%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (43%) | 3 (43%) |
| 18 | 6 (86%) | 6 (86%) |
| 30 | 6 (86%) | 6 (86%) |
| 40 | 6 (86%) | 6 (86%) |
| 50 | 6 (86%) | 6 (86%) |
| 65 | 6 (86%) | 6 (86%) |
| 75 | 6 (86%) | 6 (86%) |
| 85 | 6 (86%) | 6 (86%) |
Across all 40 studies, recruiting or not: 35% stop at 75 or younger and 33% at 65; 57% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 40 of 40. search them.
- Natural History of Sickle Cell DiseaseRecruitingNCT000815231 country
- Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive CrisisRecruitingNCT06699849Phase 23 countries
- Tocilizumab for Acute Chest SyndromeRecruitingNCT05640271Phase 21 country
- Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell DiseaseRecruitingNCT07274254Phase 32 countries
- Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP"Not yet recruitingNCT07782489
- CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell DiseaseNot yet recruitingNCT07703566Not applicable
- Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell DiseaseRecruitingNCT06818266Phase 31 country
- Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive CareRecruitingNCT07246265Not applicable1 country
- Awake Prone Positioning for Severe Acute Chest SyndromeNot yet recruitingNCT06698120Not applicable1 country
- Lung Ultrasound in Pediatric Acute Chest SyndromeRecruitingNCT064971531 country
- Early-goal Directed Automated Red Blood Cell Exchange for Acute Chest Syndrome in Sickle Cell DiseaseNot yet recruitingNCT06214845Not applicable1 country
- Ultrasound Acute Chest Syndrome Sickle Cell DiseaseCompletedNCT06880679Not applicable1 country
- Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell DiseaseTerminatedNCT01501643Not applicable1 country
- Daily Vitamin D for Sickle-cell Respiratory ComplicationsCompletedNCT04170348Phase 21 country
- Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective StudyCompletedNCT070377061 country
- Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome.CompletedNCT03919266Not applicable1 country
- Vitamin D for Sickle-cell Respiratory ComplicationsCompletedNCT01443728Phase 21 country
- Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress SyndromeCompletedNCT02582957Not applicable1 country
- Therapeutic Anticoagulation Strategy for Acute Chest SyndromeCompletedNCT02580773Phase 31 country
- Defibrotide in Sickle Cell Disease-Related Acute Chest SyndromeCompletedNCT03805581Phase 21 country
- Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest ImagingCompletedNCT034789171 country
- Validation of a Predictive Score of Acute Chest SyndromeStatus unknownNCT030320551 country
- Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive TroponinTerminatedNCT03820466Phase 31 country
- Utility of the Cardiac Electrical BiomarkerDiseaseStatus unknownNCT034981051 country
- Evaluation of Therapeutic Adherence to Inciting Spirometry in Sickle Cell PatientsCompletedNCT046673251 country
- Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.WithdrawnNCT04293172Phase 3
- Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary HypertensionCompletedNCT00023296Phase 11 country
- Feasibility Study of Unfractionated Heparin in Acute Chest SyndromeTerminatedNCT02098993Phase 21 country
- Bi-Level Positive Airway Ventilation for Acute Chest SyndromeTerminatedNCT01589926Not applicable1 country
- sPLA2 in EBC During Acute Chest SyndromeCompletedNCT032505851 country
- A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell DiseaseWithdrawnNCT02630394Phase 11 country
- Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility TrialCompletedNCT02187445Phase 11 country
- ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?CompletedNCT010413391 country
- Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease ChildrenCompletedNCT01089439Phase 21 country
- Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell DiseaseCompletedNCT01895998Phase 11 country
- IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest SyndromeCompletedNCT00434473Phase 21 country
- Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study)CompletedNCT00748423Phase 2/31 country
- Preventing Acute Chest Syndrome by Transfusion Feasibility StudyCompletedNCT00951808Not applicable1 country
- Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell DiseaseTerminatedNCT00530270Phase 31 country
- Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell DiseaseTerminatedNCT00532883Phase 21 country