Neurotoxicity Syndromes clinical trials
The registry lists 133 studies for Neurotoxicity Syndromes across more than 10 countries. 17 are recruiting or about to start. 56 of them are mainly about Neurotoxicity Syndromes (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 2 narrower conditions too, such as Tardive Dyskinesia: 215 studies, 29 open.
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Who runs them
Alliance for Clinical Trials in Oncology (12) · Gynecologic Oncology Group (6) · National Cancer Institute (NCI) (5) · M.D. Anderson Cancer Center (4) · Radiation Therapy Oncology Group (3) · Children's Oncology Group (3) · University of South Florida (3) · University Hospital, Montpellier (3)
What is being tested here
Drugs under test in Neurotoxicity Syndromes studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tacrolimus | 1 | 0 | 3 |
| Duloxetine | 1 | 1 | 2 |
| Paclitaxel | 0 | 1 | 5 |
| Carboplatin | 0 | 2 | 3 |
| Oxaliplatin | 0 | 1 | 3 |
| Remifentanil | 0 | 1 | 2 |
| Dexmedetomidine | 0 | 1 | 2 |
| Dexamethasone | 0 | 0 | 2 |
| Calcium Gluconate | 0 | 2 | 2 |
| Magnesium Sulfate | 0 | 2 | 2 |
Drug classes tested here Antimitotic agents 7 · Alkylating agents 3 · Antimetabolites 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Dec 2026A Study to Compare the Long-term Outcomes After Two Different Anaesthetics · Phase 3 · Murdoch Childrens Research Institute
- Dec 2026Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma · Phase 3 · Eastern Cooperative Oncology Group
- Feb 2027Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC) · Phase 3 · Ellis Medicine
- Apr 2027A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity · M.D. Anderson Cancer Center
- Jul 2027Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T Therapy · Instituto de Investigacion Sanitaria INCLIVA
- Aug 2027Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery · University of Chicago
- Aug 2027Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy · Ka-Wai Ho
- Sep 2027Assessing DCog Short for Neurotoxicity in CAR-T · Beth Israel Deaconess Medical Center
Who these studies take
Of the 15 Neurotoxicity Syndromes studies recruiting now, 11 (73%) set no upper age limit and 1 (7%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 15 (100%) | 15 (100%) |
| 30 | 15 (100%) | 15 (100%) |
| 40 | 15 (100%) | 15 (100%) |
| 50 | 15 (100%) | 15 (100%) |
| 65 | 15 (100%) | 15 (100%) |
| 75 | 14 (93%) | 14 (93%) |
| 85 | 11 (73%) | 11 (73%) |
Across all 133 studies, recruiting or not: 26% stop at 75 or younger and 21% at 65; 23% take children; 11% are for women only and 2% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Neurotoxicity Syndromes studies take
Of 20 observational studies under Neurotoxicity Syndromes, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 33 mo18–… · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 133. Browse all 133 → or search them.
- Assessing DCog Short for Neurotoxicity in CAR-TRecruitingNCT07403812Not applicable1 country
- Microbiome Determinants of Adverse Effects of Stereotactic RadiosurgeryRecruitingNCT077679811 country
- Delayed Toxicities Post-CAR-TRecruitingNCT076653071 country
- Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T TherapyRecruitingNCT07173166Not applicable1 country
- A Pilot Study for Pupillary Assessment to Predict CAR-T Related NeurotoxicityRecruitingNCT061441511 country
- Extracellular Vesicles and Chemotherapy-Induced Peripheral NeuropathyRecruitingNCT07558447Not applicable1 country
- Nerve Excitability in Cisplatin-Induced Peripheral NeuropathyRecruitingNCT07095998Not applicable1 country
- Longitudinal Cohort Study of Immune-Related Adverse Events in Solid Tumor Patients Treated With Immune Checkpoint InhibitorsRecruitingNCT073576361 country
- Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC)Enrolling by invitationNCT06950190Phase 31 country
- Chemotherapy Induced Peripheral Neurotoxicity (CIPN): Why Should we CareRecruitingNCT049868911 country
- ADC-induced Neurotoxicity Treated With DuloxetineRecruitingNCT06551051Phase 21 country
- Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release FormulationsRecruitingNCT05089604Phase 41 country
- Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate ToxicityRecruitingNCT060212621 country
- Effects of Lead Exposure on Ferroptosis PathwayRecruitingNCT059503861 country
- Influence of General Anesthesia on the Dynamic Changes in Brain Damage Markers During and After Craniosynostosis Operations in InfancyEnrolling by invitationNCT059111391 country
- Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single InstituteRecruitingNCT026557441 country
- Prospective Neurobehavioral Functions in Newly-diagnosed Patients With Primary CNS Lymphoma Treated With Hyperfractionated Conformal Whole-brain Radiation Therapy Plus Simultaneous Integrated BoostRecruitingNCT040065611 country
- Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System TumorsCompletedNCT014452881 country
- A Study to Compare the Long-term Outcomes After Two Different AnaestheticsActive, not recruitingNCT03089905Phase 34 countries
- Bortezomib, Thalidomide, and Dexamethasone After Melphalan and Stem Cell Transplant in Treating Patients With Stage I-III Multiple MyelomaCompletedNCT00792142Phase 21 country
- Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade GliomaActive, not recruitingNCT00978458Phase 31 country
- Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat PoisoningActive, not recruitingNCT067981421 country
- Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell LymphomaActive, not recruitingNCT03696784Phase 11 country
- Haloperidol and Lorazepam for Delirium in Patients With Advanced CancerActive, not recruitingNCT01949662Phase 21 country
- Study Evaluating Neurotoxicity in Patients With Metastatic Gastro Intestinal Cancer Taking Phycocare® or Placebo During Oxaliplatin Based ChemotherapyCompletedNCT05025826Not applicable1 country
- Neurotoxicity Evaluation of Beta-lactams in Intensive Care Unit and Identification of the Risk FactorsCompletedNCT036283001 country
- To Study the Individual Variants of Chemotherapy-Induced NeurotoxicityActive, not recruitingNCT024813361 country
- o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate CancerCompletedNCT07333976Phase 21 country
- Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-CelActive, not recruitingNCT04514029Early Phase 11 country
- Neuroprotective Effect of Neurotropin on Chronic OXA-induced Neurotoxicity in Stage II and Stage III CRC PatientsCompletedNCT07320950Phase 31 country
- A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated NeurotoxicityCompletedNCT04150913Phase 21 country
- Protective Effect of Mangafodipir Against Oxaliplatin NeurotoxicityCompletedNCT00727922Phase 21 country
- Adjusting the Dose of Therapeutic Exercise to Prevent Neurotoxicity Due to Anticancer Treatment (ATENTO)CompletedNCT04583124Not applicable1 country
- Serum Neurofilament Light (NfL) as a Marker for Brain Injury in Individuals Undergoing Chimeric Antigen Receptor-modified T TherapyTerminatedNCT046149871 country
- Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant RecipientsCompletedNCT03461445Phase 41 country
- Envarsus Neurotoxicity Burden in Liver Transplant PatientsCompletedNCT03823768Phase 41 country
- Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in ChildrenActive, not recruitingNCT04364945Not applicable1 country
- Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity SyndromeCompletedNCT05510596Not applicable1 country
- Effect of Antibiotic Choice On ReNal Outcomes (ACORN)CompletedNCT05094154Phase 41 country
- Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System LymphomaCompletedNCT01399372Phase 22 countries
- Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer PatientsStatus unknownNCT05798884Not applicable1 country
- Study Comparing Weekly Versus Every 3 Week Chemotherapy in Patients With Ovarian CancerStatus unknownNCT00660842Phase 31 country
- Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination ChemotherapyCompletedNCT01099449Phase 32 countries
- Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By SurgeryCompletedNCT01372774Phase 31 country
- the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving OxaliplatinStatus unknownNCT054943201 country
- Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly PaclitaxelCompletedNCT00039780Phase 3
- Cassava Intervention ProjectCompletedNCT03157336Not applicable1 country
- EEG Encephalopathy Patterns in Immune Effectors Cells-associated Neurotoxicity Syndrome (ICANS)Lay LanguageCompletedNCT050402301 country
- A Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated NeurotoxicityTerminatedNCT03954106Phase 21 country
- Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D PathwayTerminatedNCT01499940Phase 21 country