Lymphoma, Mantle-Cell clinical trials
The registry lists 1,220 studies for Lymphoma, Mantle-Cell across more than 10 countries. 154 are recruiting or about to start. 341 of them are mainly about Lymphoma, Mantle-Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 1,255 studies for Lymphoma, Mantle-Cell. How that becomes 1,220 here
This page counts the studies the registry files under Lymphoma, Mantle-Cell, and those it files under no condition that list Lymphoma, Mantle-Cellthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,255Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −9List Lymphoma, Mantle-Cell as a condition, but the registry did not file them under itMost often written as “Mantle Cell Lymphoma Recurrent” (4), “Mantle Cell Lymphoma Refractory” (2), and “B-cell Mantle Cell Lymphoma” (1). The registry filed them under other conditions only, most often Leukemia, Lymphocytic, Chronic, B-Cell (6) and Lymphoma, Large B-Cell, Diffuse (5).
- −26Match it another way12 name it in the title, 1 in a keyword, and 13 by a synonym or other text the search reads.
- 1,220The count on this page9 of them list Lymphoma, Mantle-Cell in their own words; the registry filed them under no condition.
Get an email when these change. Save the Lymphoma, Mantle-Cell studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
National Cancer Institute (NCI) (101) · Fred Hutchinson Cancer Center (70) · M.D. Anderson Cancer Center (47) · City of Hope Medical Center (41) · Memorial Sloan Kettering Cancer Center (32) · Masonic Cancer Center, University of Minnesota (26) · Case Comprehensive Cancer Center (24) · Mayo Clinic (22)
What is being tested here
Drugs under test in Lymphoma, Mantle-Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Zanubrutinib | 12 | 2 | 17 |
| Rituximab | 11 | 14 | 153 |
| Glofitamab | 10 | 0 | 12 |
| Obinutuzumab | 8 | 0 | 16 |
| Pirtobrutinib | 8 | 1 | 12 |
| Orelabrutinib | 8 | 2 | 9 |
| Lenalidomide | 5 | 4 | 44 |
| Acalabrutinib | 5 | 2 | 26 |
| Venetoclax | 5 | 1 | 22 |
| Sonrotoclax | 5 | 1 | 6 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 44 open · Alkylating agents 5 open · Antimetabolites 4 open · Antibody-drug conjugates (ADCs) 4 open · Proteasome inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Long-term Extension Study of PCI-32765 (Ibrutinib) · Phase 3 · Janssen Research & Development, LLC
- Jan 2027Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission · Phase 3 · ECOG-ACRIN Cancer Research Group
- Feb 2027A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL · Phase 3 · Acerta Pharma BV
- Jul 2027Bendamustine and Rituximab With or Without Orelabrutinib in MCL Treatment · Phase 3 · Ruijin Hospital
- Nov 2027Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) · Phase 3 · Loxo Oncology, Inc.
- Dec 2026Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients · University of Colorado, Denver
- Dec 2026Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma · Kami Maddocks, MD
- Dec 2026A Prospective, Single-Center Study Evaluating the Efficacy and Safety of Glofitamab Combined With Orelabrutinib and Bortezomib in Patients With High-Risk Mantle Cell Lymphoma · Ruijin Hospital
- Dec 2026Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors · Northwell Health
- Dec 2026Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies · Joshua Sasine, MD, PhD
Who these studies take
Of the 125 Lymphoma, Mantle-Cell studies recruiting now, 92 (74%) set no upper age limit and 12 (10%) stop at 75 or younger. 14 (11%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (2%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (6%) | 7 (6%) |
| 18 | 119 (95%) | 119 (95%) |
| 30 | 121 (97%) | 121 (97%) |
| 40 | 121 (97%) | 121 (97%) |
| 50 | 121 (97%) | 121 (97%) |
| 65 | 124 (99%) | 124 (99%) |
| 75 | 119 (95%) | 119 (95%) |
| 85 | 101 (81%) | 101 (81%) |
Across all 1,220 studies, recruiting or not: 22% stop at 75 or younger and 10% at 65; 18% take children; 0% are for women only and <1% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lymphoma, Mantle-Cell studies take
Of 183 phase 2 interventional studies under Lymphoma, Mantle-Cell, half reached primary completion within 63 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 61 mo36–82 · 128 studies | 57 mo31–71 · 55 studies | 64 mo39–98 · 73 studies |
| Phase 1/2 | 75 mo45–114 · 77 studies | — | 78 mo49–122 · 51 studies |
| Phase 2 | 63 mo38–106 · 183 studies | 49 mo22–87 · 30 studies | 64 mo40–108 · 153 studies |
| Phase 3 | 97 mo68–… · 27 studies | — | — |
| Interventional, no phase | 47 mo22–144 · 18 studies | — | — |
| Observational | 60 mo44–121 · 38 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting2
- Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell LymphomaOct 26, 2026NCT05861050
- Golcadomide in Combination With Rituximab for the Treatment of Patients With Relapsed or Refractory Mantle Cell LymphomaOct 22, 2026NCT07578077
Results posted1
- Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)Oct 15, 2026NCT06004167
Newly registered3
- Polatuzumab Vedotin, Mosunetuzumab, and Acalabrutinib for the Treatment of Mantle Cell Lymphoma, PAcMan TrialNov 2, 2026NCT07910435
- Natalizumab for the Prevention of ICANS in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma Receiving CAR T-Cell TherapyOct 23, 2026NCT07892027
- Phase I Safety Clinical Trial of Anti-CD19 CAR-T Therapy COL01 for the Treatment of Adults With Relapsed or Refractory B-cell Lymphoid Neoplasms: First-in-human Administration, COLIBRI.Oct 20, 2026NCT07883941
Studies
Recruiting first, then most recently updated. Showing 50 of 1,220. Browse all 1,220 → or search them.
- Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell TherapyRecruitingNCT07003295Phase 21 country
- Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) PatientsRecruitingNCT06263491Phase 21 country
- BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHLRecruitingNCT05370430Phase 11 country
- Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell LymphomaNot yet recruitingNCT07444710Phase 1
- A Study of Zanubrutinib, Obinutuzumab, and Sonrotoclax in People With Mantle Cell LymphomaNot yet recruitingNCT07799220Phase 21 country
- Auto Stem Cell Transplant for Lymphoma PatientsRecruitingNCT03125642Phase 21 country
- A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )RecruitingNCT07101328Phase 112 countries
- IKS03 in Patients With Advanced B Cell Non-Hodgkin LymphomasRecruitingNCT05365659Phase 15 countries
- Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell LymphomaRecruitingNCT05976763Phase 31 country
- Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell LymphomaRecruitingNCT06054776Phase 21 country
- Polatuzumab Vedotin, Mosunetuzumab, and Acalabrutinib for the Treatment of Mantle Cell Lymphoma, PAcMan TrialNot yet recruitingNCT07910435Phase 21 country
- Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Brexucabtagene AutoleucelAvailableNCT057761341 country
- A Study of ARC-02 in B-cell NHLRecruitingNCT07691606Phase 16 countries
- Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell LymphomaRecruitingNCT06839053Phase 21 country
- Phase Ib Clinical Study of KeynatinibRecruitingNCT04807881Phase 11 country
- A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)RecruitingNCT06742996Phase 317 countries
- Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or VenetoclaxRecruitingNCT057241211 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell MalignanciesRecruitingNCT06564038Phase 1/213 countries
- A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for Previously Untreated Mantle Cell Lymphoma in SpainRecruitingNCT07029737Phase 21 country
- Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell LymphomaRecruitingNCT05861050Phase 1/21 country
- Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)RecruitingNCT06533579Phase 1/21 country
- A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.RecruitingNCT06697184Phase 1/26 countries
- Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin LymphomaRecruitingNCT04545762Phase 11 country
- Natalizumab for the Prevention of ICANS in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma Receiving CAR T-Cell TherapyRecruitingNCT07892027Phase 21 country
- Golcadomide in Combination With Rituximab for the Treatment of Patients With Relapsed or Refractory Mantle Cell LymphomaRecruitingNCT07578077Phase 1/21 country
- Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-DegraderRecruitingNCT05294731Phase 1/21 country
- Phase I Safety Clinical Trial of Anti-CD19 CAR-T Therapy COL01 for the Treatment of Adults With Relapsed or Refractory B-cell Lymphoid Neoplasms: First-in-human Administration, COLIBRI.Not yet recruitingNCT07883941Phase 1
- A Study of APG-3288 in Relapsed/Refractory Blood CancersRecruitingNCT07424833Phase 12 countries
- Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell TherapyRecruitingNCT07341191Phase 21 country
- Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell LymphomaRecruitingNCT03523975Phase 1/21 country
- Pacritinib in Combination With a BTK Inhibitor for the Treatment of Patients With Relapsed or Refractory Mantle Cell LymphomaRecruitingNCT06675123Phase 11 country
- CLIC-2201 for the Treatment of Relapsed/Refractory B Cell MalignanciesRecruitingNCT06208735Phase 11 country
- CD79b-19 CAR T Cells in Non-Hodgkin LymphomaRecruitingNCT06026319Phase 11 country
- A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell MalignanciesRecruitingNCT05006716Phase 1/216 countries
- Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin LymphomaRecruitingNCT07763210Phase 21 country
- A Phase II Study of TT-01488 Tablets in Combination With Anti-CD20 Monoclonal Antibody Therapy in Patients With Mantle Cell LymphomaNot yet recruitingNCT07855016Phase 21 country
- Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell LymphomaRecruitingNCT06252675Phase 21 country
- Preliminary Assessment of [18F]BL40 in PET/CT ScansRecruitingNCT062243091 country
- A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.RecruitingNCT06542250Phase 1/210 countries
- The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding AreasRecruitingNCT07285044Phase 21 country
- Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCLRecruitingNCT06553872Phase 21 country
- Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T TreatmentRecruitingNCT067841671 country
- Zanubrutinib and Tafasitamab in Mantle Cell LymphomaRecruitingNCT06029309Phase 1/21 country
- CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell LymphomasEnrolling by invitationNCT07168486Phase 11 country
- Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)RecruitingNCT07225439Phase 11 country
- Real-world Study of AcalabrutinibEnrolling by invitationNCT067678911 country
- A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell LymphomaRecruitingNCT07788118Phase 1/21 country
- A Phase 3 Study to Compare the Efficacy of ICP-248 in Combination With Orelabrutinib Versus Pirtobrutinib in Participants With Relapsed or Refractory Mantle Cell Lymphoma (r/r MCL).Not yet recruitingNCT07784101Phase 31 country
- Nemtabrutinib With CAR T Therapy in Relapsed/Refractory Mantle Cell LymphomaRecruitingNCT07673367Phase 21 country