Lymphoma, B-Cell, Marginal Zone clinical trials
The registry lists 875 studies for Lymphoma, B-Cell, Marginal Zone across more than 10 countries. 111 are recruiting or about to start. 133 of them are mainly about Lymphoma, B-Cell, Marginal Zone (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 920 studies for Lymphoma, B-Cell, Marginal Zone. How that becomes 875 here
This page counts the studies the registry files under Lymphoma, B-Cell, Marginal Zone, and those it files under no condition that list Lymphoma, B-Cell, Marginal Zonethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 920Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −4List Lymphoma, B-Cell, Marginal Zone as a condition, but the registry did not file them under itMost often written as “Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive” (1), “Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma” (1), and “Ann Arbor Stage II Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue” (1). The registry filed them under other conditions only, most often Stomach Neoplasms (1) and Orbital lymphoma (1).
- −41Match it another way5 name it in the title, 2 in a keyword, and 34 by a synonym or other text the search reads.
- 875The count on this page10 of them list Lymphoma, B-Cell, Marginal Zone in their own words; the registry filed them under no condition.
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What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
National Cancer Institute (NCI) (80) · Fred Hutchinson Cancer Center (56) · Memorial Sloan Kettering Cancer Center (28) · City of Hope Medical Center (25) · Masonic Cancer Center, University of Minnesota (24) · Mayo Clinic (24) · Case Comprehensive Cancer Center (19) · Roswell Park Cancer Institute (15)
What is being tested here
Drugs under test in Lymphoma, B-Cell, Marginal Zone studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Orelabrutinib | 15 | 1 | 19 |
| Rituximab | 9 | 10 | 101 |
| Lenalidomide | 5 | 2 | 30 |
| Obinutuzumab | 4 | 0 | 10 |
| Fludarabine | 3 | 3 | 63 |
| Venetoclax | 3 | 0 | 12 |
| Pirtobrutinib | 3 | 0 | 6 |
| Epcoritamab | 3 | 0 | 5 |
| Mosunetuzumab | 3 | 1 | 4 |
| Cyclophosphamide | 2 | 4 | 66 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 26 open · Antimetabolites 4 open · Alkylating agents 3 open · Antibody-drug conjugates (ADCs) 2 open · Calcineurin inhibitors 36
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma · Phase 3 · National Cancer Institute (NCI)
- Mar 2027A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma · Phase 3 · Memorial Sloan Kettering Cancer Center
- Sep 2027Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma · Phase 3 · The Lymphoma Academic Research Organisation
- Dec 2026Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma · Kami Maddocks, MD
- Dec 2026Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT) · Sun Yat-sen University
- Dec 2026Combating Cancer-Related Fatigue: A Personalized Supportive Care Program · UNC Lineberger Comprehensive Cancer Center
- Dec 2026Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma · International Extranodal Lymphoma Study Group (IELSG)
- Dec 2026Clinical Study of OR for Second-line Treatment of Refractory MZL · Lixia Sheng
- Jan 2027Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma · AbbVie
- Jan 2027Obinutuzumab in Marginal Zone Lymphoma · Christian Buske
Who these studies take
Of the 92 Lymphoma, B-Cell, Marginal Zone studies recruiting now, 77 (84%) set no upper age limit and 7 (8%) stop at 75 or younger. 9 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (3%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (7%) | 6 (7%) |
| 18 | 90 (98%) | 90 (98%) |
| 30 | 91 (99%) | 91 (99%) |
| 40 | 91 (99%) | 91 (99%) |
| 50 | 91 (99%) | 91 (99%) |
| 65 | 91 (99%) | 91 (99%) |
| 75 | 90 (98%) | 90 (98%) |
| 85 | 81 (88%) | 81 (88%) |
Across all 875 studies, recruiting or not: 19% stop at 75 or younger and 9% at 65; 22% take children; 0% are for women only and <1% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lymphoma, B-Cell, Marginal Zone studies take
Of 113 phase 2 interventional studies under Lymphoma, B-Cell, Marginal Zone, half reached primary completion within 69 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 57 mo38–102 · 81 studies | — | 64 mo43–108 · 46 studies |
| Phase 1/2 | 78 mo49–114 · 38 studies | — | — |
| Phase 2 | 69 mo38–110 · 113 studies | — | 73 mo42–117 · 97 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered2
- PET/CT-Guided Maintenance Therapy in Previously Untreated MZLNov 4, 2026NCT07917650
- Orelabrutinib Plus ICP 248 vs Orelabrutinib for Relapsed/Refractory Marginal Zone LymphomaOct 27, 2026NCT07896590
Studies
Recruiting first, then most recently updated. Showing 50 of 875. Browse all 875 → or search them.
- Molecular and Cellular Characterization of MALT LymphomaNot yet recruitingNCT073763301 country
- Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic LymphomaRecruitingNCT04840602Phase 21 country
- Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)RecruitingNCT009235071 country
- A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone LymphomaRecruitingNCT06149286Phase 318 countries
- Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of LymphomaRecruitingNCT07249905Phase 1/23 countries
- A Study of Pirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)RecruitingNCT07231952Phase 21 country
- A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )RecruitingNCT07101328Phase 112 countries
- A Study of ARC-02 in B-cell NHLRecruitingNCT07691606Phase 16 countries
- Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone LymphomaRecruitingNCT07583810Phase 21 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- Orelabrutinib Plus ICP 248 vs Orelabrutinib for Relapsed/Refractory Marginal Zone LymphomaNot yet recruitingNCT07896590Phase 31 country
- A Study of Reduced Dose Radiation Therapy for People With B-Cell LymphomasRecruitingNCT07029217Phase 31 country
- Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin LymphomaRecruitingNCT04545762Phase 11 country
- Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)RecruitingNCT06533579Phase 1/21 country
- Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-DegraderRecruitingNCT05294731Phase 1/21 country
- A Study of APG-3288 in Relapsed/Refractory Blood CancersRecruitingNCT07424833Phase 12 countries
- Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL)RecruitingNCT06796998Phase 21 country
- Early Detection and Screening of Hematological Malignancies - SANGUINERecruitingNCT057357044 countries
- Testing Mosunetuzumab Alone, With Zanubrutinib, or With Polatuzumab Vedotin for Treating Marginal Zone Lymphoma That Came Back or Didn't Get Better With TreatmentNot yet recruitingNCT07638722Phase 21 country
- CD79b-19 CAR T Cells in Non-Hodgkin LymphomaRecruitingNCT06026319Phase 11 country
- A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell MalignanciesRecruitingNCT05006716Phase 1/216 countries
- Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin LymphomaRecruitingNCT07763210Phase 21 country
- Preliminary Assessment of [18F]BL40 in PET/CT ScansRecruitingNCT062243091 country
- Rituximab and Zanubrutinib in Patients With Indolent B-cell LymphomasRecruitingNCT06350318Phase 21 country
- Cohort Study for Gastric MALT LymphomaRecruitingNCT064541491 country
- Epco, Zanu, Ritux for R/R FL or MZLRecruitingNCT06563596Phase 21 country
- Open-label of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Marginal Zone LymphomaRecruitingNCT05296070Phase 21 country
- CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell LymphomasEnrolling by invitationNCT07168486Phase 11 country
- Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)RecruitingNCT07225439Phase 11 country
- Zanubrutinib in Patients With Waldenström's Macroglobulinemia, Chronic Lymphocytic Leukemia, Marginal Zone Lymphoma and Follicular LymphomaRecruitingNCT053263082 countries
- Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone LymphomaRecruitingNCT04792502Phase 21 country
- Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell MalignanciesRecruitingNCT06980116Phase 17 countries
- AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell LymphomasRecruitingNCT06340737Phase 11 country
- HM2023-43:Ph 2 Trial of Tafasitamab With Lenalidomide+Rituximab in Treatment-naive FL and MZLRecruitingNCT06792825Phase 21 country
- LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell MalignanciesRecruitingNCT05990465Phase 11 country
- A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell MalignanciesRecruitingNCT06708897Phase 11 country
- This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin LymphomaRecruitingNCT07121946Phase 11 country
- A Phase II Study to Evaluate the Efficacy of UF-KURE19 Cells in Patients With Relapsed or Refractory B Cell Non-Hodgkin LymphomasNot yet recruitingNCT07713459Phase 2
- Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor TherapyNot yet recruitingNCT077113271 country
- A Prospective Study of Response-adapted Low-dose Radiotherapy Combined With Orelabrutinib for Localized Mucosa-associated Lymphoid Tissue Extranodal Marginal Zone LymphomaNot yet recruitingNCT07705308Phase 21 country
- Registry Platform Hematologic Malignancies (RUBIN) - Extension of Tumor Registry Lymphatic NeoplasmsRecruitingNCT060430111 country
- Allo HSCT Using RIC and PTCy for Hematological DiseasesRecruitingNCT05805605Phase 21 country
- A Study of NX-5948 in Adults With Relapsed/Refractory B-cell MalignanciesRecruitingNCT05131022Phase 18 countries
- Combating Cancer-Related Fatigue: A Personalized Supportive Care ProgramRecruitingNCT06860880Not applicable1 country
- Epcoritamab Plus Standard of Care Platinum-Based Chemotherapy and Autologous Hematopoietic Cell Transplant for the Treatment of Relapsed or Refractory Large B-cell LymphomaRecruitingNCT06905509Phase 21 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- Myeloablative Allo HSCT With Related or Unrelated Donor for Heme DisordersRecruitingNCT03314974Phase 21 country
- Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone LymphomaRecruitingNCT0570014915 countries
- Connected Blood Pressure Monitoring in Patients With Hematologic Malignancies Initiating Covalent BTK InhibitorsNot yet recruitingNCT07592481Not applicable
- Rituximab Maintenance Versus Observation After R2 Induction in Previously Untreated Marginal Zone LymphomaNot yet recruitingNCT07654465Phase 21 country