An observational study in Mechanical Ventilation Complication and Ventilator-Induced Lung Injury, sponsored by Centre hospitalier de l'Université de Montréal (CHUM). Recruiting at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-18.
Sponsored by Centre hospitalier de l'Université de Montréal (CHUM) · Observational
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Among 15 studies in Ventilator-Induced Lung Injury with a site in Canada — 4 open to participants now, 5 under way, none of them phase 3. Ventilator-Induced Lung Injury · Canada.
Among the 15 studies in Ventilator-Induced Lung Injury with a site in Canada, this one is the only one that started in 2018, is one of 5 observational ones, and was the 9th registered.
121 studies on the registry are indexed under Ventilator-Induced Lung Injury; 39 are open to participants now.
Browse Ventilator-Induced Lung Injury studies →4 of the 15 studies in Ventilator-Induced Lung Injury with a site in Canada are open now. Recruiting first, the newest first:
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
Children's Hospital Los Angeles · Sites in Canada, United States, Italy
Ages 1 mo–18 yrs
University Health Network, Toronto · Sites in Canada
Ages 18+
A study can be open while its sites in Canada have not opened yet or have stopped. Only those recruiting at a site in Canada →
Of the 22 Ventilator-Induced Lung Injury studies recruiting now, 15 (68%) set no upper age limit and 5 (23%) stop at 75 or younger; 5 take children under 18; 1 takes healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
15 studies; the count open now beside each. This study's row is marked.
First in 2007; this study’s year is marked. 1 started in 2018.
This study's planned enrollment of 10 is below the median of 60 across 42 observational studies indexed under Ventilator-Induced Lung Injury.
Median enrollment 46 across the 10 interventional studies, 20 across the 5 observational. Of the 7 that completed or were terminated, 0 (0%) have results posted.
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None of the 15 has an industry lead sponsor. The 6 most frequent:
Centre hospitalier de l'Université de Montréal (CHUM) is the lead sponsor of 376 studies on the registry; 110 are open to participants now.
Centre hospitalier de l'Université de Montréal (CHUM) has 4 studies filed under Ventilator-Induced Lung Injury — fewer than ten, so there is no comparison to draw.
3 of the studies in Ventilator-Induced Lung Injury with a site in Canada that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06296173Centre hospitalier de l'Université de Montréal (CHUM)Open Lung Protective Extubation Following General Anesthesia | 2026-12-01 |
| NCT05875883Unity Health TorontoPhrenic Identification in the ICU | 2026-12-04 |
| NCT04068012Children's Hospital Los AngelesClinical Decision Support Tool in PARDS Pilot Study | 2027-07 |
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Among the 15 studies in Ventilator-Induced Lung Injury with a site in Canada, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting.
Hypothesis: The analysis of lung ultrasonographic sequences using speckle-tracking allows the determination of local pleural strain in 4 predetermined pulmonary areas in mechanically ventilated patients suffering from pulmonary diseases.
Mechanical ventilation is frequently used in the intensive care settings. Although essential in many cases, mechanical ventilation can be responsible for ventilator-induced lung injury (VILI). The relationship between mechanical ventilation and VILI has been clearly demonstrated in animals and is highly suspected in humans. The putative mechanism responsible for VILI is excessive pulmonary strain or overdistension. Frequently observed in mechanically ventilated patients, the presence of severe pulmonary disease can increase the risk of overdistension. The development of a tool allowing early detection of pulmonary overdistension would represent a great asset in the prevention of VILI by allowing safer adjustments of mechanical ventilation parameters. Ultrasonographic imaging is a non-radiant, non-invasive technique already available in the intensive care setting. Presently used for cardiac strain measurements, ultrasonography is a promising avenue to assess pulmonary strain.
This pilot study will aim to create a small dataset of local pleural strain values assessed in 4 predetermined pulmonary areas using ultrasonographic imaging in mechanically ventilated patients suffering from pulmonary diseases in the intensive care setting. This dataset will be used to help plan larger scale studies.
Methods:
Intensive care patients under mechanical ventilation will undergo imaging of the pleura at 4 predetermined areas. The sites to be studied will be: the 3rd intercostal space at the mid-clavicular line (left and right side), the 8th intercostal space at the posterior axillary line (left and right side). Three consecutive respiratory cycles at each site will be recorded for subsequent analysis.
Lung ultrasonography will be performed by the principal investigator and a co-investigator using a Terason (Teratech Corporation, Burlington, MA) device and a 12L5 linear ultrasound probe. For each image, the probe will be oriented perpendicularly to the pleura with the pointer towards the participant's head. The beam's focal zone will be positioned at the level of the pleural line.
Using a reference ultrasonographic image, an experienced lung ultrasonographer will segment the pleura. From this image, an algorithm will define a region of interest which will be followed throughout the rest of the images of the video sequence. Thereafter, the algorithm will calculate the various components of pulmonary strain. An experienced technician will visually validate the algorithm's tracking.
Adult Intensive care patients under mechanical ventilation suffering from a pulmonary disease.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Mechanically ventilated patients suffering from pulmonary diseases will undergo a lung ultrasonography during their stay in the intensive care unit (ICU)
Average absolute lateral deformation
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Cumulated range of absolute lateral deformation
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Average absolute axial deformation
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Cumulated range of absolute axial deformation
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Average von mises
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Average absolute lateral shear
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Cumulated range of absolute lateral shear
Change in percentage from baseline expiratory value
Time frame: At the end of study on Day 1
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2018 (actual). Primary completion is estimated for Jan 2026, 93 months after the start.
Of 30 observational studies under Ventilator-Induced Lung Injury, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 12. This study's planned 93 months is above that.
How these figures are worked out, and which studies are left out of them.
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Ventilator-Induced Lung Injury →
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