An observational study in Mechanical Ventilation Complication, Ventilator Induced Lung Injury and ARDS, sponsored by Zagazig University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Zagazig University · Observational
This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.
This prospective observational cohort study will enroll adult patients admitted to the Surgical Intensive Care Unit who require invasive mechanical ventilation. Mechanical power will be calculated during the first 72 hours of invasive mechanical ventilation using ventilatory parameters recorded during routine clinical care. Patient demographic and clinical characteristics, respiratory and ventilatory parameters, and relevant laboratory data will be recorded. Patients will be followed during their ICU stay, and 28-day mortality will be assessed as the primary outcome. The association between mechanical power and 28-day mortality will be evaluated using appropriate statistical analyses, including receiver operating characteristic (ROC) curve analysis to assess the predictive performance of mechanical power.
120 studies on the registry are indexed under Ventilator-Induced Lung Injury; 39 are open to participants now.
This study's planned enrollment of 116 is above the median of 60 across 42 observational studies indexed under Ventilator-Induced Lung Injury.
Browse Ventilator-Induced Lung Injury studies →Zagazig University is the lead sponsor of 459 studies on the registry; 77 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Adult patients requiring invasive mechanical ventilation and admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adult patients requiring invasive mechanical ventilation and admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.
28-Day Mortality
All-cause mortality within 28 days after initiation of invasive mechanical ventilation.
Time frame: At 28 days after initiation of invasive mechanical ventilation
Driving Pressure and Plateau Pressure
Correlation between mechanical power and driving pressure and plateau pressure at 24, 48, and 72 hours.
Time frame: At 24, 48, and 72 hours after initiation of invasive mechanical ventilation
Ventilator-Free Days
Number of ventilator-free days within the first 28 days.
Time frame: Through 28 days after initiation of invasive mechanical ventilation
ICU Length of Stay
Duration of stay in the intensive care unit
Time frame: From ICU admission until ICU discharge or death, through 28 days after initiation of invasive mechanical ventilation
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Ventilator-Induced Lung Injury →