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Not yet recruitingNCT07811973Updated Sep 10, 2026

Management of Arachnoid Nerve Tethering in Trigeminal Neuralagia

An interventional study of Arachnoid nerve detethering in Trigeminal Neuralgia, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-10.

Sponsored by Assiut University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
23
Allocation
Not applicable
Ages
18 Years to 80 Years
Sex
All
01

Study summary

This study aims to evaluate the clinical significance of arachnoid-trigeminal nerve conflict in patients with medically refractory trigeminal neuralgia without demonstrable neurovascular conflict on preoperative magnetic resonance imaging (MRI). Patients undergoing surgical exploration will be assessed clinically, radiologically, and intraoperatively for the presence and characteristics of arachnoid adhesions or tethering involving the trigeminal nerve. Endoscopic-assisted arachnoid release will be performed when appropriate. Postoperative pain outcome will be evaluated using the Barrow Neurological Institute (BNI) pain intensity score and the Visual Analog Scale (VAS). Recurrence, postoperative complications, MRI-intraoperative correlation, and potential predictors of favorable surgical outcome will also be evaluated.

02

Conditions studied

  • Trigeminal Neuralgia

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03

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age more 18
  • Failed medical treatment

Exclusion criteria

Exclusion Criteria:

  • Vascular compression
  • Tumors
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
23 participants (estimated)

Study arms

  • Experimental
    Trigeminal neuralgia

    Arachnoid nerve detethering

    Procedure: Arachnoid nerve detethering

Interventions

  • ProcedureArachnoid nerve detethering

    Endoscopic assisted

05

What researchers measure

Primary outcomes

  1. Bni (Barrow Neurological Institute) score improvement

    Pain free without medication

    Time frame: 2years

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07811973
Lead sponsor
Assiut University
Responsible party
Mohamed Amgad Kotb (Mohamed, Assiut University) — Principal investigator
First posted
Sep 10, 2026
Start date
Aug 31, 2026 (estimated)
Primary completion
Aug 31, 2028 (estimated)
Completion
Sep 30, 2028 (estimated)
Last update
Sep 10, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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