Tooth Discoloration clinical trials
The registry lists 105 studies for Tooth Discoloration across more than 10 countries. 19 are recruiting or about to start. 86 of them are mainly about Tooth Discoloration (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-21.
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Breast cancer · Recruiting: 2 came in, 3 changed
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Status
Who runs them
Cairo University (19) · Tanta University (4) · University of Chile (4) · Ege University (3) · Boka LLC (3) · Home Skinovations Ltd. (3) · Marmara University (3) · Federal University of Pelotas (3)
What is being tested here
Drugs under test in Tooth Discoloration studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Evaluation of 2-year Clinical Performance of Two Different Single Color Universal Composite Resin Restorative Materials. · Baskent University
- Dec 2026A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up · HALEON
- Feb 2027Peroxide Versus Non-Peroxide In-Office Tooth Bleaching · Minia University
- Mar 2027Children Acceptance of AgNP Mouthwash Against Chlorhexidine 0.12% and Chlorhexidine .2% Mouthwashs · Cairo University
- Apr 2027Clinical Evaluation of Prefabricated Versus 3D-Printed Composite Resin Veneers: in Vivo Study · Tanta University
- Aug 2027Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste · King Abdullah University Hospital
- Oct 2027Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia · University Hospital, Toulouse
Who these studies take
Of the 8 Tooth Discoloration studies recruiting now, 1 (13%) set no upper age limit and 7 (88%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 7 (88%) | 7 (88%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 6 (75%) | 6 (75%) |
| 50 | 5 (63%) | 5 (63%) |
| 65 | 2 (25%) | 2 (25%) |
| 75 | 1 (13%) | 1 (13%) |
| 85 | 1 (13%) | 1 (13%) |
Across all 105 studies, recruiting or not: 78% stop at 75 or younger and 71% at 65; 14% take children; 0% are for women only and 1% for men only; 76% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tooth Discoloration studies take
Of 52 interventional studies with no phase under Tooth Discoloration, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo2–18 · 52 studies | — | 10 mo5–21 · 44 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered3
- Color Stability of Darkly Discolored Arrested Caries Lesions Following Bleaching TreatmentOct 21, 2026NCT07886255
- Clinical Research Study to Evaluate Stain Removal and Whitening ImprovementOct 13, 2026NCT07870018
- 450 nm Blue Diode Laser Versus Blue LED for In-Office Tooth BleachingOct 13, 2026NCT07870317
Studies
Recruiting first, then most recently updated. Showing 50 of 105. Browse all 105 → or search them.
- Children Acceptance of AgNP Mouthwash Against Chlorhexidine 0.12% and Chlorhexidine .2% MouthwashsNot yet recruitingNCT07200063Not applicable
- Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial ToothpasteNot yet recruitingNCT07850232Not applicable1 country
- Peroxide Versus Non-Peroxide In-Office Tooth BleachingRecruitingNCT07818031Not applicable1 country
- A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-upRecruitingNCT07836998Not applicable1 country
- Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office BleachingNot yet recruitingNCT07770373Not applicable
- Comparison of Erythritol Air-Polishing and Conventional Polishing Following Ultrasonic Scaling on the Relapse of Chromogenic Tooth Staining in ChildrenNot yet recruitingNCT07730658Not applicable1 country
- Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in MicroabrasionRecruitingNCT07709286Phase 11 country
- Oil Pulling Whitening MouthwashRecruitingNCT07667088Not applicable1 country
- Dental Dyschromia and Quality of Life in Early Prolonged HyperbilirubinemiaRecruitingNCT065067341 country
- Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized NightguardsRecruitingNCT07464197Not applicable1 country
- 16% Carbamide Peroxide Home Bleaching: Soft vs. Rigid Tray in a Randomized Blinded Equivalence TrialEnrolling by invitationNCT06881654Not applicable1 country
- A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching AgentEnrolling by invitationNCT06782087Phase 11 country
- Efficacy and Safety Assessment of Experimental Bleaching AgentsNot yet recruitingNCT06802614Not applicable1 country
- Comparison of Color Measurements of Postgraduate Dental Students Using Different Color Determination MethodsEnrolling by invitationNCT067916941 country
- Bleaching Effect of Solo and Combined Kiwi Extract and Ozone and Their Impact on EnamelNot yet recruitingNCT06582069Not applicable
- Effects of Bio-active Desensitizer on Reduction of Tooth Sensitivity Caused by In-office Bleaching.RecruitingNCT06532526Not applicable1 country
- Prevalence of Teeth Discoloration , Associated Risk Factors and the Most Common Shade Among Group of Egyptian PopulationNot yet recruitingNCT06515561
- Dental Photography and Numeric Shade Quantification as a Substitute to Conventional and Instrumental Shade Matching Techniques in the Esthetic ZoneRecruitingNCT04817579Not applicable1 country
- Composite Repair Using Silane Coupling AgentNot yet recruitingNCT06392685Not applicable
- Color Stability of Darkly Discolored Arrested Caries Lesions Following Bleaching TreatmentCompletedNCT078862551 country
- Guided Biofilm Therapy Versus Conventional Polishing for Tooth Re-StainingCompletedNCT07799558Not applicable1 country
- Clinical Research Study to Evaluate Stain Removal and Whitening ImprovementCompletedNCT07870018Phase 21 country
- 450 nm Blue Diode Laser Versus Blue LED for In-Office Tooth BleachingCompletedNCT07870317Not applicable1 country
- TOOTH DİSCOLORATİON AFTER ROOT CANAL TREATMENT WİTH AH PLUS AND BİOROOT RCSCompletedNCT07849296Not applicable1 country
- Clinical Efficacy of Novel Titanium Oxide Nanoparticle Enriched Bleaching GelCompletedNCT06904118Not applicable1 country
- Clinical Evaluation of Discoloration Induced by Root Canal Treatment in Vital and Devital TeethActive, not recruitingNCT077819691 country
- The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use.CompletedNCT07761715Not applicable1 country
- A Clinical Study to Evaluate the Stain Reduction Efficacy of a Non-Fluoride Tooth Whitening Dentifrice Containing Nano-Hydroxyapatite (nHAP) and a High Cleaning Silica Abrasive System Compared to a Commercial Fluoride Non-Whitening Dentifrice as a Negative ControlCompletedNCT07214038Not applicable1 country
- The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use.CompletedNCT07219342Not applicable1 country
- Clinical Evaluation of Prefabricated Versus 3D-Printed Composite Resin Veneers: in Vivo StudyActive, not recruitingNCT07691658Not applicable1 country
- Management of Dentinal Hypersensitivity Using Two Dentifrice TechnologiesCompletedNCT07511530Not applicable1 country
- Comparison of Two Minimally Invasive Approaches for Masking Molar-Incisor Hypomineralization OpacitiesCompletedNCT07494682Not applicable1 country
- Efficacy of Manual Toothbrushes in Removing Tooth StainsCompletedNCT06486974Phase 31 country
- A Comparative Clinical Study Assessing Dentin Thickness and Discoloration in Deep Carious Lesions Treated With Biodentine Alone Versus Diode Laser Pre-treatment Followed by BiodentineActive, not recruitingNCT07358442Not applicable1 country
- At-home Bleaching Using Clear RetainersCompletedNCT05835453Not applicable1 country
- Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery SystemsCompletedNCT04649645Not applicable1 country
- Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled TrialCompletedNCT06886438Not applicable1 country
- Evaluation of Tooth Sensitivity and Whitening Effects of Different Content Teeth Whitening AgentsActive, not recruitingNCT06855940Not applicable1 country
- Evaluation of 2-year Clinical Performance of Two Different Single Color Universal Composite Resin Restorative Materials.Active, not recruitingNCT06125132Not applicable1 country
- Phototherapy Remediation of Black StainCompletedNCT03309748Not applicable
- Bleaching Procedures Performed During Treatment With Brackets and Clear AlignersCompletedNCT06716827Not applicable1 country
- Clinical Efficacy of In-office Bleaching With Different Concentrations of Hydrogen PeroxideCompletedNCT06700434Not applicable1 country
- Er,Cr:YSGG Laser Bleaching on Tooth Color and SensitivityCompletedNCT06666920Not applicable1 country
- Clinical Assessment of Injectable Flowable Composite with Giomer Technology Vs High Viscosity Glass Ionomer Restorations in ART for Cancer PatientsCompletedNCT05465369Phase 31 country
- Evaluation of Template Assisted Monochromatic Structural Colored Versus Universal Multi-Shade Direct Composite VeneersCompletedNCT06543654Not applicable1 country
- Clinical Evaluation of Single Versus Multi-Shade Direct Composite Resin VeneersCompletedNCT06404398Not applicable1 country
- Clinical Evaluation of Color Stability of Direct Composite Resin Veneers in Vital Anterior TeethCompletedNCT06510400Not applicable1 country
- Impact of a Newly Formulated Toothpaste in Tooth Staining Associated With Chlorhexidine RinsesCompletedNCT05354986Not applicable1 country
- Tooth Discoloration Induced by Pulpotomy MaterialsActive, not recruitingNCT04346849Not applicable1 country
- Clinical Performance of Ceramic Laminate Veneers Made With Celtra Duo Press and IPS e.Max Press CeramicCompletedNCT03713970Not applicable1 country