An interventional study of peroxide -based in office tooth bleaching and non-peroxide -based in office tooth bleaching in Tooth Discoloration and Tooth Staining, sponsored by Minia University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Minia University · Not applicable, Interventional, and Treatment
This randomized clinical trial aims to compare the effectiveness of peroxide and non-peroxide in-office tooth bleaching systems. The study will evaluate tooth whitening efficacy, color durability over time, and tooth sensitivity after treatment. Participants will receive one of the two bleaching treatments and will be followed for six months to assess the clinical outcomes and compare the performance of both systems.
This randomized controlled clinical trial is designed to compare the clinical performance of peroxide-based and non-peroxide in-office tooth bleaching systems. Eligible participants will be randomly allocated into two treatment groups. Tooth color will be assessed using standardized clinical evaluation methods before treatment, immediately after bleaching, and during follow-up visits. The study will also evaluate color stability and tooth sensitivity over a six-month follow-up period. The findings are expected to provide evidence regarding the effectiveness and safety of both bleaching systems and to support evidence-based clinical decision-making in esthetic dentistry.
105 studies on the registry are indexed under Tooth Discoloration; 19 are open to participants now.
This study's planned enrollment of 50 is close to the median of 48 across 97 interventional studies indexed under Tooth Discoloration.
Browse Tooth Discoloration studies →Minia University is the lead sponsor of 370 studies on the registry; 117 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive a peroxide-based in-office tooth bleaching treatment according to the manufacturer's instructions.
Procedure: peroxide -based in office tooth bleaching
Participants will receive a non-peroxide-based in-office tooth bleaching treatment according to the manufacturer's instructions.
Procedure: non-peroxide -based in office tooth bleaching
Participants will receive an in-office peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
Participants will receive an in-office non- peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
Bleaching efficacy measured by Whiteness Index for Dentistry (WID)
Bleaching efficacy will be assessed using the Whiteness Index for Dentistry (WID), obtained by spectrophotometric measurement of the anterior teeth at baseline, immediately after treatment, and at 1, 3, and 6 months after treatment. The change in WID (ΔWID) from baseline will be calculated at each post-treatment time point. Higher WID values indicate greater tooth whiteness.
Time frame: Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
Color durability measured by CIEDE2000 color difference (ΔE00)
Color durability will be evaluated using spectrophotometric measurements and the CIEDE2000 color difference formula (ΔE₀₀), a standardized method developed by the International Commission on Illumination (CIE) to quantify color differences. Color differences between the immediate post-treatment measurement and each follow-up measurement at 1, 3, and 6 months will be calculated. A ΔE₀₀ value of 0 indicates no color difference, whereas higher values indicate greater color difference from the immediate post-treatment color.
Time frame: Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
Tooth sensitivity assessed using the Visual Analog Scale (VAS)
Tooth sensitivity will be assessed using a 0-10 Visual Analog Scale (VAS), with a minimum score of 0 indicating no pain and a maximum score of 10 indicating the worst possible pain. Higher scores indicate greater tooth sensitivity and pain.
Time frame: Daily during the 14-day treatment period
Plan to share: No — individual participant data will not be shared because there is no plan for public data sharing beyond the analyses and results reported in the study.
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Feb 2027, 6 months after the start.
Of 44 non-industry interventional studies with no phase under Tooth Discoloration, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 21. This study's planned 6 months is below that.
Counting every sponsor, half of 52 studies reached it within 8 months; a quarter within 2 and three quarters within 18.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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