An observational study in Tooth Discoloration Following Root Canal Treatment and Tooth Discoloration, sponsored by Marmara University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-27.
Sponsored by Marmara University · Observational
Among 17 studies in Tooth Discoloration with a site in Turkey — 2 open to participants now, 5 under way, none of them phase 3. Tooth Discoloration · Turkey.
Among the 17 studies in Tooth Discoloration with a site in Turkey, this one is one of 2 that started in 2025, is one of 4 observational ones, and was the 15th registered.
105 studies on the registry are indexed under Tooth Discoloration; 19 are open to participants now.
Browse Tooth Discoloration studies →2 of the 17 studies in Tooth Discoloration with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 8 Tooth Discoloration studies recruiting now, 1 (13%) set no upper age limit and 7 (88%) stop at 75 or younger; 2 take children under 18; 4 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →17 studies; the count open now beside each. This study's row is marked.
First in 2016; this study’s year is marked. 2 started in 2025.
Median enrollment 55 across the 13 interventional studies, 42 across the 4 observational. Of the 11 that completed or were terminated, 0 (0%) have results posted.
None of the 17 has an industry lead sponsor. The 10 most frequent:
Marmara University is the lead sponsor of 599 studies on the registry; 138 are open to participants now.
Marmara University has 3 studies filed under Tooth Discoloration — fewer than ten, so there is no comparison to draw.
1 of the studies in Tooth Discoloration with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06125132Baskent UniversityEvaluation of 2-year Clinical Performance of Two Different Single Color Universal Composite Resin Restorative Materials. | 2026-11-01 |
Among the 17 studies in Tooth Discoloration with a site in Turkey, from their registry updates:
This prospective observational study aims to evaluate and compare tooth discoloration following root canal treatment in vital and devital teeth. Patients with maxillary premolar teeth requiring root canal treatment are included in the study. Before treatment, the teeth are classified as vital or devital based on their pulpal status. All teeth receive root canal treatment and coronal restoration using a standardized clinical protocol. Tooth color is objectively measured with a spectrophotometer before treatment and at 3, 6, and 9 months after treatment. Changes in tooth color over time are evaluated and compared between vital and devital teeth.
This prospective, single-center observational study is designed to investigate whether the preoperative pulpal status of a tooth is associated with the degree of discoloration occurring after root canal treatment.
Maxillary first and second premolar teeth requiring primary root canal treatment are evaluated clinically and radiographically. Before treatment, pulpal status is assessed using electric pulp testing and cold testing, and the teeth are classified as vital or devital according to the findings. Root canal treatment and coronal restoration are performed by the same operator using a standardized clinical protocol to minimize treatment-related variability.
Tooth color is assessed objectively using a VITA Easyshade V spectrophotometer under standardized conditions. At each assessment, three consecutive measurements are obtained from the middle third of the buccal surface, and the mean values are recorded. Changes in tooth color are evaluated throughout the follow-up period to determine the extent and progression of discoloration and to compare the color changes between vital and devital teeth.
Patients presenting to the Department of Endodontics, Faculty of Dentistry, Marmara University, with maxillary first or second premolar teeth requiring root canal treatment constitute the study population. Eligible participants are evaluated clinically and radiographically according to predefined eligibility criteria. Before treatment, pulpal status is assessed using electric pulp testing and cold testing, and the included teeth are classified as vital or devital based on the findings.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Maxillary first and second premolar teeth requiring primary root canal treatment and classified as vital based on preoperative pulpal status assessed using electric pulp testing and cold testing.
Procedure: Root Canal Treatment
Maxillary first and second premolar teeth requiring primary root canal treatment and classified as devital based on preoperative pulpal status assessed using electric pulp testing and cold testing.
Procedure: Root Canal Treatment
Root canal treatment is performed in a single visit by the same operator using a standardized clinical protocol. Following local anesthesia and rubber dam isolation, an access cavity is prepared and the working length is determined using an electronic apex locator and confirmed with periapical radiography. Root canals are prepared using a nickel-titanium rotary instrumentation system. Sodium hypochlorite (NaOCl) is used during instrumentation, followed by a final irrigation protocol with 17% ethylenediaminetetraacetic acid (EDTA) and 2.5% NaOCl with irrigant activation. The canals are subsequently dried with sterile paper points. Root canal obturation is performed in the same visit using gutta-percha and AH Plus root canal sealer with the cold lateral condensation technique. After obturation, excess gutta-percha is removed and the coronal level of the root canal filling is standardized at approximately 2 mm apical to the cementoenamel junction. Residual root canal sealer is removed fr
Change in Tooth Color (ΔE00)
Tooth color is objectively assessed using a VITA Easyshade V spectrophotometer. CIELAB L\*, a\*, and b\* values are recorded from the middle third of the buccal surface of each tooth. Three consecutive measurements are obtained at each assessment, and the mean values are used for analysis. Overall tooth color change between baseline and each follow-up time point is calculated using the CIEDE2000 color difference formula (ΔE00). Higher ΔE00 values indicate a greater magnitude of color difference. Changes in ΔE00 are compared between vital and devital teeth.
Time frame: Baseline, 3 months, 6 months, and 9 months
Change in Tooth Lightness (ΔL*)
Changes in tooth lightness are assessed using the CIELAB L\* coordinate obtained with a VITA Easyshade V spectrophotometer. ΔL\* is calculated as the difference in L\* values between measurement time points. Positive ΔL\* values indicate an increase in lightness, whereas negative ΔL\* values indicate a decrease in lightness (darkening). ΔL\* is calculated for baseline to 3 months, baseline to 6 months, baseline to 9 months, 3 to 6 months, 3 to 9 months, and 6 to 9 months. ΔL\* values are compared between vital and devital teeth.
Time frame: Baseline, 3 months, 6 months, and 9 months
Change in Red-Green Color Coordinate (Δa*)
Changes in the red-green color coordinate are assessed using CIELAB a\* values obtained with a VITA Easyshade V spectrophotometer. Δa\* is calculated as the difference in a\* values between measurement time points. Positive Δa\* values indicate a shift toward red, whereas negative Δa\* values indicate a shift toward green. Δa\* is calculated for baseline to 3 months, baseline to 6 months, baseline to 9 months, 3 to 6 months, 3 to 9 months, and 6 to 9 months. Δa\* values are compared between vital and devital teeth.
Time frame: Baseline, 3 months, 6 months, and 9 months
Change in Yellow-Blue Color Coordinate (Δb*)
Changes in the yellow-blue color coordinate are assessed using CIELAB b\* values obtained with a VITA Easyshade V spectrophotometer. Δb\* is calculated as the difference in b\* values between measurement time points. Positive Δb\* values indicate a shift toward yellow, whereas negative Δb\* values indicate a shift toward blue. Δb\* is calculated for baseline to 3 months, baseline to 6 months, baseline to 9 months, 3 to 6 months, 3 to 9 months, and 6 to 9 months. Δb\* values are compared between vital and devital teeth.
Time frame: Baseline, 3 months, 6 months, and 9 months
Plan to share: No — Individual participant data are not planned to be shared publicly due to participant confidentiality and data protection considerations. Study results will be reported in an aggregated and anonymized form.
No publications or documents are linked to this record.
Started Sep 2025 (actual). Primary completion is estimated for Oct 2026, 13 months after the start.
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This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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