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Not yet recruitingNCT07770373Updated Aug 18, 2026

Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching

An interventional study of Treatment in Discolored Teeth, sponsored by Cairo University. Not yet recruiting. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-08-18.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Aug 2026, 3 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
38
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

To evaluate the effect of prophylaxis pastes with and without desensitizing agents prior to in-office bleaching on color change and tooth sensitivity.

02

Conditions studied

  • Discolored Teeth

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Keywords

  • bleaching
  • desensitizing agents
  • discoloration
03

In context

Tooth Discoloration

105 studies on the registry are indexed under Tooth Discoloration; 19 are open to participants now.

This study's planned enrollment of 38 is below the median of 48 across 97 interventional studies indexed under Tooth Discoloration.

Browse Tooth Discoloration studies →

Lead sponsor

Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who have discolored teeth, minimum of 20 natural teeth, good oral hygiene, do not have any systemic disease.

Exclusion criteria

Exclusion Criteria:

  • Patients who have extensive prosthesis or restoration, tetracycline discoloration or fluorosis, endodontically treated teeth or gingival recession, smokers, periodontal disease, pregnant or lactating.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
38 participants (estimated)

Study arms

  • Experimental
    Prophylaxis paste with desensitizing agent

    Prophylaxis paste with desensitizing agent

    Other: Treatment

  • Placebo comparator
    Prophylaxis paste without desensitizing agent

    Prophylaxis paste without desensitizing agent

    Other: Treatment

Interventions

  • OtherTreatment

    Prophylaxis paste will be applied to all tooth surfaces using a prophy cup attached to a low-speed contra-angle handpiece. The paste will remain on the teeth for the duration specified in the manufacturer's instructions for use before being rinsed away.

06

What researchers measure

Primary outcomes

  1. Color change

    Tooth color will be measured using the VITA Easyshade V spectrophotometer. Color measurements will be recorded in the CIE L\*, a\*, and b\* color space, and the color difference will be calculated using the CIEDE2000 color-difference formula (ΔE00).

    Time frame: Baseline, Immediate after bleaching

Secondary outcomes

  1. Tooth sensitivity

    Pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst pain imaginable). Patients will be asked to place a mark on the 10-cm VAS corresponding to the intensity of their pain.

    Time frame: Baseline, Immediate after bleaching

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Aug 2026; primary completion for Aug 2026, 0 months later.

Of 44 non-industry interventional studies with no phase under Tooth Discoloration, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 21. This study's planned 0 months is below that.

Counting every sponsor, half of 52 studies reached it within 8 months; a quarter within 2 and three quarters within 18.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 6, 2026
First posted
Aug 18, 2026
StartEst.
Aug 2026
Primary completionEst.
Aug 2026
CompletionEst.
Aug 2026
Last update
Aug 18, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07770373
Lead sponsor
Cairo University
Responsible party
Zeinab Omar Tolba (Associate Professor, Conservative Dentistry Department, Faculty of Dentistry, Cairo University, Cairo University) — Principal investigator
First posted
Aug 18, 2026
Start date
Aug 2026 (estimated)
Primary completion
Aug 2026 (estimated)
Completion
Aug 2026 (estimated)
Last update
Aug 18, 2026

Study contacts

Zeinab O Tolba, Associate Professor
Contact
zeinab.omar@dentistry.cu.edu.eg
+2 01222308738
Possy M Abd El Aziz, Associate Professor
Contact
possy.moustafa@dentistry.cu.edu.eg
+2 01061023968
Zeinab O Tolba, Associate Professor
principal investigator · Cairo University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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