Tauopathies clinical trials
The registry lists 75 studies for Tauopathies across more than 10 countries. 18 are recruiting or about to start. 6 of them are mainly about Tauopathies (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Alzheimer Disease: 4,131 studies, 975 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Tammie L. S. Benzinger, MD, PhD (5) · University of Pennsylvania (4) · Eli Lilly and Company (4) · AbbVie (4) · Inmune Bio, Inc. (3) · MODAG GmbH (3) · AstraZeneca (3) · Chang Gung Memorial Hospital (2)
What is being tested here
Drugs under test in Tauopathies studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| ML-007C | 2 | 0 | 2 |
| NIO752 | 1 | 0 | 2 |
| XENP 1595 | 0 | 0 | 3 |
| Donepezil | 0 | 2 | 3 |
| Emrusolmin | 0 | 0 | 3 |
| Tilavonemab | 0 | 0 | 3 |
| Flortaucipir | 0 | 0 | 3 |
| Lanabecestat | 0 | 3 | 3 |
| Izaflortaucipir F-18 | 0 | 0 | 2 |
| Donanemab | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- May 2027Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease · Tharick Pascoal
- Jun 2027Trial of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease or Primary Tauopathies · Arrowhead Pharmaceuticals
- Nov 2027Tau PET/CT in Various Tau-Related Disease Patients · Tianjin Medical University
Who these studies take
Of the 15 Tauopathies studies recruiting now, 6 (40%) set no upper age limit and 1 (7%) stop at 75 or younger. 1 (7%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 8 (53%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (7%) | 1 (7%) |
| 18 | 7 (47%) | 7 (47%) |
| 30 | 7 (47%) | 7 (47%) |
| 40 | 11 (73%) | 11 (73%) |
| 50 | 13 (87%) | 13 (87%) |
| 65 | 15 (100%) | 15 (100%) |
| 75 | 15 (100%) | 15 (100%) |
| 85 | 12 (80%) | 12 (80%) |
Across all 75 studies, recruiting or not: 12% stop at 75 or younger and 5% at 65; 3% take children; 0% are for women only and 1% for men only; 36% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tauopathies studies take
Of 12 phase 2 interventional studies under Tauopathies, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 33 mo22–39 · 12 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Tau Pathology in the Brain After Hip or Knee Replacement SurgeryOct 13, 2026NCT07871487
Studies
Recruiting first, then most recently updated. Showing 50 of 75. Browse all 75 → or search them.
- Trial of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease or Primary TauopathiesRecruitingNCT07221344Phase 1/22 countries
- A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's DiseaseRecruitingNCT06297590Phase 13 countries
- Tau Pathology in the Brain After Hip or Knee Replacement SurgeryRecruitingNCT078714871 country
- A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary TauopathiesNot yet recruitingNCT07868328Phase 2
- A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease PsychosisRecruitingNCT06887192Phase 215 countries
- Tau PET/CT in Various Tau-Related Disease PatientsRecruitingNCT066909831 country
- [18F]NIDF PET Imaging in Tau-related DiseasesRecruitingNCT073065981 country
- Neurodegenerative Diseases Progression Markers (MARKERS-NDD)RecruitingNCT065967461 country
- An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease PsychosisEnrolling by invitationNCT07459660Phase 23 countries
- Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease - EUNot yet recruitingNCT07708675Not applicable
- F 18 T807 Tau PET Imaging of Alzheimer's DiseaseRecruitingNCT024143471 country
- Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503RecruitingNCT06303921Early Phase 11 country
- CW2IP2: Imaging and Diagnostic AssessmentsRecruitingNCT06083467Not applicable1 country
- Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183ARecruitingNCT06932809Early Phase 11 country
- Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15RecruitingNCT06032026Early Phase 11 country
- Proteinopathies Expression in Skin of Neurodegenerative DisordersRecruitingNCT065289641 country
- Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)RecruitingNCT061702681 country
- Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute ConditionsRecruitingNCT04684602Phase 1/21 country
- A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)Active, not recruitingNCT05508789Phase 38 countries
- Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease ParticipantsActive, not recruitingNCT05469360Phase 14 countries
- Head-to-Head Harmonization of Tau Tracers in Alzheimer's DiseaseActive, not recruitingNCT05361382Phase 13 countries
- First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the BrainCompletedNCT07348276Early Phase 11 country
- A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of InflammationCompletedNCT05318976Phase 28 countries
- Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD SubjectsTerminatedNCT06304883Phase 33 countries
- A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's DiseaseCompletedNCT05063539Phase 25 countries
- Myotonic Dystrophy - Vascular and CognitionActive, not recruitingNCT046562101 country
- A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01TerminatedNCT06247345Phase 11 country
- An Open-Label Extension of XPro1595 in Patients With Alzheimer's DiseaseTerminatedNCT05522387Phase 21 country
- Validation of Blood Biomarkers for Alzheimer's DiseaseCompletedNCT05427448Not applicable1 country
- Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care SystemsCompletedNCT05080777Not applicable1 country
- A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's DiseaseCompletedNCT04445831Phase 1/24 countries
- F 18 T807 Tau PET Imaging of Frontotemporal Dementia (FTD)WithdrawnNCT02707978Phase 21 country
- CNS Tau Kinetics in Healthy Aging and Alzheimer's DiseaseCompletedNCT039388701 country
- Harmony at Home: A Pilot Telehealth Program for Rural ADRD CaregiversCompletedNCT05202223Not applicable1 country
- Nicotinamide as an Early Alzheimer's Disease TreatmentCompletedNCT03061474Phase 21 country
- Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of InflammationWithdrawnNCT05321498Phase 2
- Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's DiseaseCompletedNCT03903211Phase 21 country
- Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's DiseaseCompletedNCT01539031Phase 31 country
- A First-in-Human Study to Assess Single Doses of APNmAb005 in Healthy ParticipantsActive, not recruitingNCT05344989Phase 11 country
- Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in HumansCompletedNCT032877651 country
- A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)CompletedNCT05532358Phase 11 country
- A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's DiseaseCompletedNCT04685265Phase 11 country
- A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese PopulationCompletedNCT05527288Not applicable1 country
- A Study of LY3303560 in Participants With Early Symptomatic Alzheimer's DiseaseCompletedNCT03518073Phase 23 countries
- A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's DiseaseCompletedNCT02880956Phase 211 countries
- Human CNS Tau Kinetics in TauopathiesCompletedNCT035451261 country
- Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive AphasiaTerminatedNCT03153540Not applicable1 country
- A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressive Supranuclear Palsy (PSP)TerminatedNCT02985879Phase 28 countries
- An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP)TerminatedNCT03391765Phase 25 countries
- Novel Neuroimage Study in Tauopathies With ParkinsonismCompletedNCT03386669Phase 21 country