Supranuclear Palsy, Progressive clinical trials
The registry lists 171 studies for Supranuclear Palsy, Progressive across more than 10 countries. 51 are recruiting or about to start. 88 of them are mainly about Supranuclear Palsy, Progressive (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
University of California, San Francisco (8) · University of Pennsylvania (5) · Adam Boxer (4) · Massachusetts General Hospital (4) · Molecular NeuroImaging (4) · IRCCS San Raffaele Roma (4) · Assistance Publique Hopitaux De Marseille (3) · Nantes University Hospital (3)
What is being tested here
Drugs under test in Supranuclear Palsy, Progressive studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| AADvac1 | 2 | 0 | 2 |
| Flortaucipir | 1 | 0 | 3 |
| NIO752 | 1 | 0 | 1 |
| Tributyrin | 1 | 0 | 1 |
| Nicotinamide-beta-riboside | 1 | 0 | 1 |
| Coenzyme Q10 | 0 | 1 | 3 |
| Tilavonemab | 0 | 0 | 3 |
| Gosuranemab | 0 | 0 | 3 |
| Bepranemab | 0 | 0 | 2 |
| PI-2620 | 0 | 0 | 2 |
Drug classes tested here Cholinesterase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) · Ferrer Internacional S.A.
- Nov 2026Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling · University Health Network, Toronto
- Dec 2026Diagnosing Frontotemporal Lobar Degeneration · University Health Network, Toronto
- Dec 2026Collection of Digital Parameters From Parts of the Neurological Examination Using an Eye Tracker · University of Kiel
- Dec 2026Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers · Beijing Tiantan Hospital
- Dec 2026Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging · University of Texas Southwestern Medical Center
- Dec 2026AI-Enhanced Optimization of Acute Levodopa Challenge Test · Beijing Tiantan Hospital
- Feb 2027Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases · IRCCS San Raffaele
- Mar 2027Automated Imaging Differentiation of Parkinsonism · University of Florida
- Mar 2027Synaptic Loss in Multiple System Atrophy · University of Exeter
Who these studies take
Of the 38 Supranuclear Palsy, Progressive studies recruiting now, 22 (58%) set no upper age limit and 2 (5%) stop at 75 or younger. 5 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 14 (37%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (11%) | 4 (11%) |
| 18 | 22 (58%) | 22 (58%) |
| 30 | 28 (74%) | 28 (74%) |
| 40 | 32 (84%) | 32 (84%) |
| 50 | 38 (100%) | 38 (100%) |
| 65 | 38 (100%) | 38 (100%) |
| 75 | 38 (100%) | 38 (100%) |
| 85 | 31 (82%) | 31 (82%) |
Across all 171 studies, recruiting or not: 4% stop at 75 or younger and 1% at 65; 8% take children; 0% are for women only and 0% for men only; 37% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Supranuclear Palsy, Progressive studies take
Of 15 phase 1 interventional studies under Supranuclear Palsy, Progressive, half reached primary completion within 22 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 22 mo17–23 · 15 studies | — | — |
| Interventional, no phase | 45 mo29–… · 28 studies | — | — |
| Observational | 81 mo54–… · 37 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 171. Browse all 171 → or search them.
- The Progressive Supranuclear Palsy Clinical Trial PlatformRecruitingNCT07173803Phase 21 country
- Trial of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease or Primary TauopathiesRecruitingNCT07221344Phase 1/22 countries
- Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaRecruitingNCT032251441 country
- Early Molecular Biomarkers for Differentiating Parkinsonian SyndromesEnrolling by invitationNCT076048831 country
- The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen B: LM11A-31Enrolling by invitationNCT07264283Phase 21 country
- The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1Enrolling by invitationNCT07217665Phase 21 country
- Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual TrialRecruitingNCT07863180Phase 1/21 country
- Transcranial Magnetic Stimulation in Progressive Supranuclear PalsyRecruitingNCT04468932Not applicable1 country
- A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear PalsyRecruitingNCT07498426Phase 312 countries
- Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy BodiesNot yet recruitingNCT072408051 country
- A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary TauopathiesNot yet recruitingNCT07868328Phase 2
- ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)RecruitingNCT043636842 countries
- Wellness in PSP and CBDRecruitingNCT07844655Not applicable1 country
- Neurodegenerative Diseases RegistryRecruitingNCT044721301 country
- VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and ParkinsonismNot yet recruitingNCT078279631 country
- Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSPNot yet recruitingNCT07818733Not applicable1 country
- Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)RecruitingNCT078059671 country
- Neurodegenerative Diseases Progression Markers (MARKERS-NDD)RecruitingNCT065967461 country
- Biofluid Research on Age-Related or Inherited NeurodegenerationRecruitingNCT077987001 country
- Remote Monitoring in Progressive Supranuclear Palsy (PSP)Not yet recruitingNCT047533201 country
- Individualized Transcranial Magnetic Stimulation in Parkinsonian DisordersRecruitingNCT07570212Not applicable1 country
- Neurologic Stem Cell Treatment StudyRecruitingNCT02795052Not applicable2 countries
- A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear PalsyRecruitingNCT02605785Not applicable1 country
- Tracking and Predicting How Brain Damage Spreads in Neurodegenerative DiseasesEnrolling by invitationNCT07567664Not applicable1 country
- Study to Evaluate the Feasibility of Syde® Digital Endpoints for Monitoring Patients With Progressive Supranuclear Palsy - Richardson Syndrome (PSP-R)Not yet recruitingNCT073890181 country
- The Swedish BioFINDER 2 StudyRecruitingNCT03174938Not applicable1 country
- Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic DisordersRecruitingNCT07509125Not applicable1 country
- Synaptic Loss in Multiple System AtrophyRecruitingNCT051210121 country
- Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital BiomarkersRecruitingNCT073924111 country
- Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using NeuroimagingRecruitingNCT038721021 country
- UPenn Observational Research Repository on Neurodegenerative DiseaseRecruitingNCT047153991 country
- The CurePSP Genetics ProgramRecruitingNCT066476411 country
- Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183ARecruitingNCT06932809Early Phase 11 country
- tDCS as Treatment for Motor FunctionRecruitingNCT07291687Not applicable1 country
- Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative ModelingRecruitingNCT065297441 country
- Collection of Digital Parameters From Parts of the Neurological Examination Using an Eye TrackerNot yet recruitingNCT071417191 country
- Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic PathologyRecruitingNCT07136844Not applicable1 country
- AI-Enhanced Optimization of Acute Levodopa Challenge TestRecruitingNCT069498651 country
- Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative DiseasesRecruitingNCT047062348 countries
- Diagnosing Frontotemporal Lobar DegenerationRecruitingNCT029646371 country
- Parkinson Atypical Rating of Oculometric Patterns Evaluated RoutinelyEnrolling by invitationNCT06597071Not applicable1 country
- NYSCF Scientific Discovery BiobankRecruitingNCT062031061 country
- The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical ParkinsonismRecruitingNCT06162013Phase 21 country
- The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related DisordersRecruitingNCT06174948Not applicable1 country
- Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian SyndromesRecruitingNCT066456261 country
- NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian SyndromeRecruitingNCT064909261 country
- Quality of Life of the Patient and the Burden of the Caregiver in Progressive Supranuclear PalsyRecruitingNCT036385051 country
- Early Biomarkers of Neurodegeneration in Parkinsonian SyndromesNot yet recruitingNCT06155942Not applicable1 country
- Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian PatientsRecruitingNCT05139342Not applicable1 country
- Biomarkers in Parkinsonian SyndromesRecruitingNCT021142421 country