Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 5 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid TumorsRecruitingNCT05914116Phase 1/2
• A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell CancersRecruitingNCT05910827Phase 1/2
• A Phase I/II Study of VLS-1488 in Subjects With Advanced CancerRecruitingNCT05902988Phase 1/2
• Differential Mobility Spectrometry (DMS) Based Oral Tumor AnalysisRecruitingNCT05902455
• Evaluating 111In Panitumumab for Nodal Staging in Head and Neck CancerRecruitingNCT05901545Phase 1
• A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)RecruitingNCT05894083Phase 2
• A Study Evaluating the Safety and Efficacy of PRV111, PRV211, and PRV131 in Subjects With Oral and Lung CancersRecruitingNCT05893888Phase 2/3
• A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer TreatmentRecruitingNCT05889091Not applicable
• A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H MutationRecruitingNCT05877599Phase 1
• Articulatory Adaptation Following Oral Cancer TreatmentRecruitingNCT05876247
• TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.RecruitingNCT05872880
• Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II TrialRecruitingNCT05862168Phase 2
• Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT05861557Phase 2
• A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor CancerRecruitingNCT05859074Phase 1
• The Efficacy and Safety of De-escalated Postoperative Radiotherapy in Locally Advanced HNSCC With pCR/MPRRecruitingNCT05854823Not applicable
• Intratumoral Gemcitabine, Paclitaxel, Carboplatine and Intravenous Nivolumab for Locally Recurrence of Head and Neck CancersNot yet recruitingNCT05835804Phase 2
• The Effect of Nitozumab in the Treatment of Head and Neck Squamous Cell CarcinomaRecruitingNCT05831930Early Phase 1
• The Effect of Prebiotic Inulin on Patients Affected by R/M HNSCC Treated With Immune Checkpoint InhibitorsRecruitingNCT05821751Not applicable
• Elective vs Therapeutic Neck Dissection in Treatment of Patients With Clinical T1/2N1M0 Oral Squamous Cell CarcinomaNot yet recruitingNCT05806073Not applicable
• Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical TherapyNot yet recruitingNCT05803915Phase 2
• Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant TherapyRecruitingNCT05793151Not applicable
• Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral CavityRecruitingNCT05791149Not applicable
• HRYZ-T101 TCR-T Cell for HPV-18 Positive Advanced Solid TumorRecruitingNCT05787535Phase 1
• A Study of DB-1310 in Advanced/Metastatic Solid TumorsRecruitingNCT05785741Phase 1/2
• Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid TumorsRecruitingNCT05784688Phase 1/2
• A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT05783921Phase 1/2
• Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe NegativeRecruitingNCT05774483Not applicable
• Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT05773079Phase 2
• First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid TumorsRecruitingNCT05768139Phase 1/2
• Fluorescence-guided Surgery in Laryngeal- and Hypopharyngeal Cancer: a Feasibility TrialRecruitingNCT05752149Phase 2
• A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With RM-SCCHNRecruitingNCT05751512Phase 3
• (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell CarcinomaRecruitingNCT05747625Phase 1
• Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCCRecruitingNCT05726370Phase 2
• Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer.RecruitingNCT05719779Not applicable
• PET/CT Follow up for Head and Neck Squamous Cell CarcinomaRecruitingNCT05707078Not applicable
• 3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized TrialRecruitingNCT05674396Phase 2
• Liquid Biopsy for Early DiagNosis of Squamous Cell Carcinoma of the HeAd and NeCk rEgionRecruitingNCT05645783
• Quantifying Systemic Immunosuppression to Personalize Cancer TherapyRecruitingNCT05621837
• Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal CancersNot yet recruitingNCT05582590Phase 1
• Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Head and Neck Squamous Cell Carcinoma (REDUCTION-I)RecruitingNCT05582265Phase 3
• SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal CancersRecruitingNCT05582122Phase 2
• A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)RecruitingNCT05576974Phase 2
• Drug Screening Using Novel IMD in Salivary and Head and Neck CancersRecruitingNCT05553782Early Phase 1
• A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck CancerRecruitingNCT05544136Phase 2
• The Role of Circulating Tumour DNA in Head and Neck CancerRecruitingNCT05539638
• Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck CancerRecruitingNCT05526924Phase 1
• The Registry Study of Genetic Alterations of Oropharyngeal Cancer in TaiwanRecruitingNCT05522881
• A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected MalignanciesRecruitingNCT05473156Phase 1/2
• Sodium Selenite Supplementation in Patients With Head and Neck CancerRecruitingNCT05451576Not applicable
• Detection of Oral and Throat Cancers Using OralViome Cancer Testing SystemRecruitingNCT05451303
• Pembrolizumab in Combination With Low-dose PFas Neoadjuvant Treatment for Locally Advanced HNSCCRecruitingNCT05446467Phase 2
• Peritumoral Microbubbles and CEUS for SLN Detection and Biopsy in HNSCCRecruitingNCT05437380Not applicable
• A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck CancerRecruitingNCT05420948Phase 2
• The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)RecruitingNCT05419089Phase 2
• SOTO: Treatment Sensitivity of Organoids to Predict Treatment OutcomeRecruitingNCT05400239
• HYpofractionated, Dose-redistributed RAdiotherapy With Protons and Photons in HNSCCRecruitingNCT05364411Not applicable
• Special Care Patterns for Elderly HNSCC Patients Undergoing RadiotherapyRecruitingNCT05337631
• Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study.RecruitingNCT05333523Phase 3
• Modi-1 Moditope in Breast, Head and Neck, Ovarian, or Renal CancerRecruitingNCT05329532Phase 1/2
• 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCCRecruitingNCT05317000Phase 2
• A Study of Pembrolizumab (MK-3475) Plus Platinum and Gemcitabine as First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (PIPER)RecruitingNCT05286619Phase 2
• Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable TumorsRecruitingNCT05280314Phase 2
• Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCCRecruitingNCT05272696Phase 2
• Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid TumorsRecruitingNCT05269381Phase 1/2
• Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell CarcinomaRecruitingNCT05268614Phase 2
• Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic CancerRecruitingNCT05267626Phase 1/2
• Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable DiseaseRecruitingNCT05229614Phase 2
• Do Markers of Systemic Inflammatory Response and Tumor Metabolism Indicate Radioresistance in Head and Neck Cancer?RecruitingNCT05217212
• A Study of PF-08046054/SGN-PDL1V in Advanced Solid TumorsRecruitingNCT05208762Phase 1
• Artificial Intelligence in Functional Imaging for Individualized Treatment of Head and Neck Squamous Cell Carcinoma PatientsRecruitingNCT05192655
• Study of Camrelizumab in Combination With Apatinib Mesylate Plus Albumin-bound Paclitaxel and Cisplatin as the First Line Treatment of Recurrent or Metastatic, UnresectableHead and Neck Squamous Cell CarcinomaNot yet recruitingNCT05189184Phase 2
• Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell CarcinomaRecruitingNCT05183048Early Phase 1
• Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid TumorsRecruitingNCT05176483Phase 1
• RAPA-201 Therapy of Solid TumorsRecruitingNCT05144698Phase 1/2
• BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot StudyRecruitingNCT05136196Phase 2
• Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCCRecruitingNCT05125055Phase 2/3
• Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and NeckRecruitingNCT05108090Not applicable
• A Study of NX-1607 in Adults With Advanced MalignanciesRecruitingNCT05107674Phase 1
• Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002)RecruitingNCT05098119Phase 2
• A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer AgentsRecruitingNCT05094804Phase 1/2
• A Beta-only IL-2 ImmunoTherapY StudyRecruitingNCT05086692Phase 1/2
• Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC PatientsRecruitingNCT05069857Phase 2
• Neoadjuvant DaRT for Locally Advanced Oral Cavity SCCNot yet recruitingNCT05065346Not applicable
• ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy EvaluationRecruitingNCT05059444
• Alpha Radiation Emitters Device (DaRT) in Combination With Check Point Inhibitor for the Treatment of Recurrent Unresectable or mHNSCCRecruitingNCT05047094Not applicable
• Single-agent Capecitabine as Metronomic Chemotherapy in LAHNSCC (CMHN)RecruitingNCT05044117Phase 3
• IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid TumorsRecruitingNCT05039801Phase 1
• Virtual Reality 3D-Surgery Modeling to Enhance Head and Neck Cancer Surgery QualityRecruitingNCT05031910Not applicable
• Exploring the Application Value of PET Molecular Imaging Targeting FAP in Oral Squamous Cell CarcinomaRecruitingNCT05030597
• Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell CarcinomaRecruitingNCT05025813Phase 2
• Dissecting the Heterogeneity of Oral Cancer PainRecruitingNCT05024383Not applicable
• Nimotuzumab Combined With Radiotherapy in High-risk Patients With HNSCC Not Suitable for Cisplatin After SurgeryNot yet recruitingNCT05024019Phase 2
• Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab AdizutecanRecruitingNCT05005403Phase 1
• A Study of Toripalimab as Consolidation Therapy After Postoperative Chemoradiotherapy in HNSCCRecruitingNCT04992559Phase 2
• A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid TumorsRecruitingNCT04895709Phase 1/2
• Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and RadiotherapyRecruitingNCT04892849
• JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCCRecruitingNCT04892173Phase 3
• Camrelizumab as a Maintenance Therapy After Chemoradiation in Patients With Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT04861467Phase 2
• Study of Pembrolizumab Combined with Chemotherapy in the First Line Therapy for R/M HNSCC in ChinaRecruitingNCT04857164Phase 2
• Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell CarcinomaRecruitingNCT04852328Phase 2

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