Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 1 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• Bacterial Decolonization to Prevent Severe Radiation Dermatitis in Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07888907Not applicable
• Optimizing Response to Immunotherapy With Online Adaptive Pulsed Radiotherapy in Incurable Head and Neck CancersNot yet recruitingNCT07888816Phase 2
• A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid TumorsRecruitingNCT07887971Phase 1
• MTX-531-001 Phase 1 Study in Advanced Solid TumorsNot yet recruitingNCT07874880Phase 1
• Hypofractionated Radiotherapy in Older Adults With Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07847060Not applicable
• ImmunoADC Therapy for Induction Conversion in Patients With Stage IVB OSCC/OPSCCNot yet recruitingNCT07844551Phase 2
• Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer TriageNot yet recruitingNCT07842211Not applicable
• Safety and Efficacy of Ruxolitinib in Patients With HNSCC and High NLR Treated With Pembrolizumab - The Phase 2 InflammaSTOP TrialNot yet recruitingNCT07840456Phase 2
• Neoadjuvant Sintilimab Plus Chemotherapy for cT2N0M0 Oral Squamous Cell CarcinomaNot yet recruitingNCT07827872Phase 3
• Indocyanine Green With Near Infrared Imaging for Intraoperative Visualization of Head and Neck Squamous Cell CarcinomaRecruitingNCT07825597
• Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck CancerNot yet recruitingNCT07823309Not applicable
• Becotatug Vedotin Plus Pucotenlimab and Platinum Chemotherapy in Locally Advanced Epidermal Growth Factor Receptor (EGFR)-Positive Head and Neck Squamous Cell CarcinomaRecruitingNCT07814287Phase 2
• A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid TumorsRecruitingNCT07814248Phase 1
• Rimegepant-Sensitized Neoadjuvant Chemoimmunotherapy for Oral or Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT07812467Phase 2
• A Study to Assess Adverse Events, Change in Disease Activity and How Intravenous ABBV-253 Moves Through the Body in Adult Participants With Advanced Solid TumorsRecruitingNCT07807956Phase 1
• Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or MetastaticRecruitingNCT07807345Phase 1
• A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCCRecruitingNCT07807163Phase 2
• HYperfractionated Radiation Therapy Versus Concurrent Chemoradiation for Head and Neck Cancer (HYTC)RecruitingNCT07801235Not applicable
• Prognostic Biomarkers for Patients With Human Papillomavirus (HPV) Positive Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT07797738Not applicable
• Sequential Toripalimab and Paclitaxel in Patients With Head and Neck Squamous Cell Cancer (HNSCC) and Poor Performance StatusNot yet recruitingNCT07796126Phase 2
• Trop2-targeting NIR-II Molecular Probe for Precision Diagnosis of Oral CancerRecruitingNCT07794813
• A Clinical Trial Comparing the Efficacy and Safety of Anyouping® and Platinum-based Chemotherapy With or Without Enlituo® in Advanced Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.RecruitingNCT07791745Phase 2/3
• A Study of BL-M08D1 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsNot yet recruitingNCT07788950Phase 2
• Scheduled IV Fluids in the Supportive Management of Patients Undergoing Chemo-radiotherapy for Head and Neck CancerNot yet recruitingNCT07784855Not applicable
• Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI TrialNot yet recruitingNCT07783581Phase 2
• Response-adapted Postoperative Radiotherapy In Locally Advanced Head and Neck CancerNot yet recruitingNCT07780877Phase 2
• Adebrelimab Combined With Dalpiciclib Isethionate Plus Chemotherapy for Neoadjuvant Treatment of Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07778732Phase 2
• A Multicenter, Prospective, Phase II Study of TROP-2 ADC in Combination With Toripalimab for Resectable Locally Advanced Oral Squamous Cell CarcinomaNot yet recruitingNCT07778368Phase 2
• Induction PD-1 Inhibitor and Chemotherapy Followed by Chemoradiotherapy in Unresectable or Inoperable HPV-negative LA-HNSCCNot yet recruitingNCT07776340Phase 2
• A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell CarcinomaRecruitingNCT07768189Phase 3
• Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell CarcinomaNot yet recruitingNCT07766889Phase 2
• Online Sharing for Head & Neck Cancer SupportRecruitingNCT07766226Not applicable
• SYS6010 vs Investigator's Choice of Monotherapy in Patients With Recurrent or Metastatic HNSCCNot yet recruitingNCT07758621Phase 3
• Anti-PD-1 Therapy in Recurrent and Metastatic Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07751289Phase 2
• Perioperative Finotonlimab Plus Chemotherapy in Untreated Stage II HNSCCNot yet recruitingNCT07751276Phase 2
• Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell CarcinomaNot yet recruitingNCT07745803
• A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT07744126Phase 2
• A Study of IOV-5001 in Adults With Advanced Solid TumorsNot yet recruitingNCT07743723Phase 1/2
• Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell CarcinomaRecruitingNCT07741643Phase 1
• Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07741565Early Phase 1
• A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid TumorsRecruitingNCT07730021Phase 1/2
• Study Comparing Different Neck Treatment Approaches in Patients With Oral Cancer Without Visible Neck SpreadRecruitingNCT07726199Not applicable
• Study Comparing Limited and Extensive Neck Surgery in Oral Cancer Patients With Neck SpreadRecruitingNCT07717307Not applicable
• Effects of a Perma-h Model Mobile-based Rehabilitation Support Program on Hope, Self-efficacy, Perceived Social Support and Rehabilitation Outcomes in Post- Tracheostomy Oral Cancer PatientsNot yet recruitingNCT07714967Not applicable
• Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell CarcinomaNot yet recruitingNCT07692360
• Thermotherapy for Head and Neck Cancer PatientsRecruitingNCT07690618Phase 1
• Objective Response Rate of Ivonescimab With Chemotherapy in Locally Advanced Resectable Oral and Oropharyngeal Squamous Cell CarcinomaRecruitingNCT07686575
• Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07683507Phase 2
• The Importance of Mucosal Screening in the Prevention of Oral Cancer.Enrolling by invitationNCT07682883Not applicable
• Trilaciclib Combined With Immunochemotherapy for R/M HNSCCNot yet recruitingNCT07679997Phase 2
• MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07677475Phase 2
• Evaluating the Optimal Timing of Acupuncture for Managing Chemoradiation-induced Xerostomia in Patients With Head and Neck CancersNot yet recruitingNCT07674706Not applicable
• Integrated Early-CARE for Head & Neck Cancer.Not yet recruitingNCT07671573Not applicable
• A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC ParticipantsRecruitingNCT07668154Phase 2
• Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate CancerRecruitingNCT07667400Phase 1/2
• APG-157 in Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07667296Phase 3
• Neoadjuvant EGFR-ADC Combined With Anti-PD-1 Monoclonal Antibody in Resectable Locally Advanced Hypopharyngeal Squamous Cell CarcinomaRecruitingNCT07665190Phase 2
• A Phase II Trial for MOR Antagonism With Axelopran to Enhance Immunotherapy in Head and Neck CancerNot yet recruitingNCT07662720Phase 1/2
• CCR2 PET Imaging Head and Neck Squamous Cell CarcinomaRecruitingNCT07659678Phase 2
• Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.RecruitingNCT07654647Not applicable
• Pharmacokinetic Study of Pembrolizumab and Its Impact on Immunity and the Tumor Microenvironment, Which May Explain the Efficacy of Post-immunotherapy Chemotherapy.Not yet recruitingNCT07633613Phase 4
• Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard ChemoradiationNot yet recruitingNCT07628062Phase 2
• A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.Not yet recruitingNCT07623642Phase 2
• A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid TumorsRecruitingNCT07623369Phase 1
• BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy ProgressionEnrolling by invitationNCT07618624Phase 2
• EGFR/HER2 Dual-Target CAR-NK Cells for Recurrent or Metastatic HNSCCRecruitingNCT07617805Phase 1/2
• Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer PatientsEnrolling by invitationNCT07606638Not applicable
• A Study of IDP-001 in Advanced or Metastatic Solid TumorsRecruitingNCT07602842Phase 1/2
• Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07601737Phase 2
• Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid TumorsRecruitingNCT07589205Phase 1
• Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II StudyNot yet recruitingNCT07589049Phase 2
• Pucotenlimab Plus Becotatug Vedotin in Perioperative Treatment of Locally Advanced Resectable Head and Neck Squamous Cell CarcinomaRecruitingNCT07586124Phase 2
• Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid TumorsRecruitingNCT07584499Phase 1
• Proton Versus Photon Therapy in Head and Neck Squamous Cell Carcinomas.RecruitingNCT07580300Phase 3
• Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell CarcinomaNot yet recruitingNCT07579507Not applicable
• Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO TrialNot yet recruitingNCT07576725Phase 2
• Trial Evaluating Hypo-fractionated Accelerated Versus Conventional Fractionated Adjuvant RT in Head & Neck MalignanciesRecruitingNCT07573956Phase 2/3
• Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCCRecruitingNCT07572864Phase 2
• Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin FibrosisRecruitingNCT07567235Phase 1
• Pilot Study of Bone Mineral Density Changes During Anti-PD-1 ImmunotherapyRecruitingNCT07555210Not applicable
• Neoadjuvant Radio-immunotherapy Versus Immunotherapy Alone for Locally Advanced HNSCCNot yet recruitingNCT07554768Phase 2
• Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)Not yet recruitingNCT07552558Phase 1/2
• Neoadjuvant Treatment of Locally Advanced HNSCC With Pertuzumab Combined With Lenvatinib.Enrolling by invitationNCT07550972Phase 2
• A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT07546383Not applicable
• Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)Not yet recruitingNCT07545083Phase 2
• Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07535567Phase 2/3
• A Bidirectional Study of Individualized Postoperative Adjuvant Treatment Decision Model for Locally Advanced Head and Neck Squamous Cell Carcinoma Based on Multimodal Dynamic DataEnrolling by invitationNCT07532928
• Phase II Study of Ficerafusp Alfa in Combination With Nivolumab in Patients With Platinum-refractory Head and Neck Squamous Cell CarcinomaRecruitingNCT07529873Phase 2
• Artificial Intelligence for the Diagnosis of Oral LesionsNot yet recruitingNCT07529769
• Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid TumorsRecruitingNCT07517198Phase 1
• Evaluation of the Efficacy and Safety of Nivolumab Neoadjuvant Treatment of Patients With Locally Advanced Oral Squamous Cell CarcinomaNot yet recruitingNCT07514767Phase 2
• Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer PatientsRecruitingNCT07514754Not applicable
• Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)RecruitingNCT07513389Phase 2
• Matching Primary Tumor and Blood Gene Expression Analysis of HPV-negative Squamous Head and Neck CancersRecruitingNCT07512921
• GALENOS 1 in Head and Neck, Lung, and Rectal Cancer PatientsRecruitingNCT07511413
• Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCCRecruitingNCT07509099Phase 3
• Hypofractionated Radiotherapy for Postoperative Intermediate-Risk Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07507058Not applicable
• A Study of Adaptive Radiotherapy of Head-neck Cancer Using Daily Replanning and Optimization of the Treatment Plan.RecruitingNCT07506902Not applicable
• A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors TypesRecruitingNCT07503808Phase 1
• Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell CarcinomaRecruitingNCT07497607Phase 2

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