Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 4 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell CarcinomaRecruitingNCT06492460Phase 3
• HN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response BiomarkersRecruitingNCT06487403Not applicable
• A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell CarcinomaRecruitingNCT06485778Phase 2
• Molecular Imaging of DNA Damage Response by [18F]-Olaparib PETNot yet recruitingNCT06482307Phase 1/2
• Tirilizumab with Albumin-bound Paclitaxel and Cisplatin for Locally Advanced Resectable Oral Squamous Cell CarcinomaRecruitingNCT06470217Phase 2
• A Study of BL-B16D1 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT06469008Phase 1
• A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid TumorsRecruitingNCT06465069Phase 1
• Identification of Pattern and Factors Affecting Recurrence in Head and Neck CarcinomaRecruitingNCT06465030
• This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid TumorsRecruitingNCT06451497Phase 1
• A Study of VET3-TGI in Patients With Solid TumorsRecruitingNCT06444815Phase 1
• A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT06444009Phase 2
• NBI for Early Diagnosis of OPMD/OSCCNot yet recruitingNCT06438939Not applicable
• A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT06437522Phase 2
• Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)RecruitingNCT06425146Not applicable
• A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced CancersRecruitingNCT06422403Phase 2
• Dysphagia and Quality of Life in Patients With Oral Squamous Cell Carcinoma Before and After TreatmentNot yet recruitingNCT06407570
• A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck CancerRecruitingNCT06385080Phase 1/2
• A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid TumorsNot yet recruitingNCT06383507Phase 1
• A Phase I/II Trial of UCB4594 in Participants With Advanced CancerRecruitingNCT06380816Phase 1/2
• Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and OutcomeRecruitingNCT06380686
• App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)TherapyRecruitingNCT06367257Not applicable
• Tirelizumab in Combination With Carboplatin and Polymeric Micellar Paclitaxel for Neoadjuvant Therapy in cN+ HNSCCNot yet recruitingNCT06366945Phase 2
• Oropharynx (OPX) Biomarker TrialRecruitingNCT06356272
• "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)RecruitingNCT06336941Not applicable
• Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLCRecruitingNCT06332755Phase 1
• A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)RecruitingNCT06330064Phase 1/2
• Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal CancerRecruitingNCT06323460Phase 2
• Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Clinically Node-negative Head and Neck Squamous Cell CarcinomaRecruitingNCT06323369Phase 2
• SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence TomographyRecruitingNCT06321003
• 177Lu-anti-PD-L1 sdAb in Metastatic Solid TumorsRecruitingNCT06305962Early Phase 1
• Myeloprotection With Trilaciclib in Pan-cancer PopulationNot yet recruitingNCT06297811Phase 2
• The Combination of Adebrelimab and TP Regimen for Neoadjuvant Therapy in Patients With Stage IVB Oral Squamous Cell CarcinomaRecruitingNCT06277791Phase 2
• Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) ProgramRecruitingNCT06265285Phase 2
• Neoadjuvant Immunochemotherapy for LAOSCCRecruitingNCT06258811Phase 3
• A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell CarcinomaRecruitingNCT06256588Phase 3
• a Multicentre Phase III Study of Risk-based Treatment Intensification With Hyperfractionated Radiotherapy in Head and Neck Cancer PatientsRecruitingNCT06248996Phase 3
• A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 1
• A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral BloodRecruitingNCT06240689Phase 2
• PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCCRecruitingNCT06239220Phase 2
• Identification of the Pathogenetic Mechanisms Underlying Squamous Cell CarcinomasRecruitingNCT06236464
• Neoadjuvant Tislelizumab Plus Chemotherapy for Resectable Locally-advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT06235918Phase 2
• Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) CancerRecruitingNCT06223568Phase 2
• Envafolimab Combined With Chemotherapy in Neoadjuvant and Conversion Therapy for Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06218004Phase 2
• Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT06211335Phase 1
• Study of the Role of Oncostatin M in Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06199947Not applicable
• Neoadjuvant Adebrelimab Plus Dalpiciclib in Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06199271Phase 2
• Clinical Trial of SIBP-03 in Patients With Head and Neck Squamous Cell CarcinomaRecruitingNCT06194656Phase 2
• Clinical Study of GT201 in Combination With PD-1 Inhibitor for Advanced Head and Neck TumorsRecruitingNCT06190275Not applicable
• Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton TherapyRecruitingNCT06183268Not applicable
• Validity of Viome's Oral/throat Cancer TestRecruitingNCT06174428
• Postoperative CCRT Followed by Immunotherapy in High-Risk LA HNSCCRecruitingNCT06170710Phase 2
• Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell CarcinomaRecruitingNCT06170697Phase 2
• A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT06163534
• Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study.RecruitingNCT06162377Phase 4
• Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell CarcinomaRecruitingNCT06161545Phase 2
• A Phase 1 of CTX-8371 in Patients With Advanced MalignanciesRecruitingNCT06150664Phase 1
• Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell CarcinomaRecruitingNCT06142318Phase 2
• A New Mutational and Epigenetic Signature to Predict Early OPSCC RelapseRecruitingNCT06138483
• European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]RecruitingNCT06137378Phase 2
• Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004)RecruitingNCT06130332Phase 2
• A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.Not yet recruitingNCT06130007Phase 2
• PABLIXIMAB as Neoadjuvant Therapy for Head and Neck Squamous-cell CarcinomaNot yet recruitingNCT06125223
• A Study of YL202 in Selected Patients With Advanced Solid TumorsRecruitingNCT06107686Phase 2
• Cetuximab+Zimberelimab in Combination With Cisplatin and Nab-paclitaxel in Resctable Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06107114Phase 2
• Efficacy and Safety of Netupitant and Palonosetron Hydrochloride Capsules in Preventing Nausea and Vomiting Induced by Radiochemotherapy in Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06102447Not applicable
• Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCCRecruitingNCT06102395Phase 3
• Efficacy and Safety of PD-1 Plus Chemotherapy in Poorly Differentiated Locally Advanced (LA) HNSCCRecruitingNCT06100497Phase 2
• Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)RecruitingNCT06097468Phase 1/2
• Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)RecruitingNCT06088381Phase 2
• Dose Escalation Using Hypoxia-adjusted RadiotherapyRecruitingNCT06087614Phase 2
• A Study of Head and Neck MRI and Tumor Microenvironment BiomarkersRecruitingNCT06085781Not applicable
• Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400RecruitingNCT06084481Phase 1
• Toripalimab in Combined With Cetuximab，Chemotherapy for Conversion Therapy of Locally Nonresectable OCSCCRecruitingNCT06081582Phase 2
• A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell CarcinomaRecruitingNCT06064877Phase 3
• Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to ImmunotherapiesRecruitingNCT06061705Not applicable
• Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain MetastasisRecruitingNCT06047379Phase 1/2
• De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and NeckRecruitingNCT06030440Phase 2/3
• A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.RecruitingNCT06022029Phase 1
• Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell CarcinomaRecruitingNCT06016920Phase 1/2
• Adelbelimab Combination Chemotherapy in Neoadjuvant Therapy for Squamous Cell Carcinoma of the Head and NeckNot yet recruitingNCT06016413Phase 2
• Using Vitamin D to Reduce Oral Mucosal Inflammation in Chemotherapy Patients With Oral Squamous Cell CarcinomaRecruitingNCT06016400Phase 2/3
• Real-world Analysis on the Efficacy and Safety of Neoadjuvant Therapy for Head and Neck Squamous Cell Carcinoma （neoHNSCC）RecruitingNCT06011993
• ARTEMIS-006: HS-20093 in Patients With Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT06007729Phase 2
• A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT06006169Phase 2
• Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation TherapyRecruitingNCT05996432Early Phase 1
• Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCCNot yet recruitingNCT05993858Phase 2
• Study to Assess GTAEXS617 in Participants With Advanced Solid TumorsRecruitingNCT05985655Phase 1/2
• Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid TumorsRecruitingNCT05983432Phase 1
• PD-1 Inhibitor Therapy Versus Radiotherapy in pCR Patients With Locally Advanced HNSCC After Neoadjuvant ImmunochemotherapyRecruitingNCT05980715Phase 3
• Calizumab Combined With Bevacizumab and Capecitabine in the Treatment of Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT05965154Phase 2
• Temporal Diffusion Spectroscopy MRI in Predicting the CPS of PD-L1 Expression and the Efficacy of Neoadjuvant TherapyRecruitingNCT05964595
• HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell CarcinomaRecruitingNCT05962242Phase 2
• HRYZ-T101 Injection for HPV18 Positive Solid TumorRecruitingNCT05952947Phase 1
• Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce RecurrenceRecruitingNCT05952934Phase 2
• Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter StudyRecruitingNCT05946577
• Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck CancerRecruitingNCT05945875Phase 1
• A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid TumorsRecruitingNCT05941507Phase 1/2
• Tirelizumab in Combination With Carboplatin and Albumin-binding Paclitaxel for Neoadjuvant Therapy in HNSCCRecruitingNCT05941338Phase 2
• WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMARecruitingNCT05927220
• HN-QUEST: A Study of Head and Neck Imaging BiomarkersRecruitingNCT05919290Not applicable

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