Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 3 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• Head and Neck Cancer Study Project in the Geriatric PopulationRecruitingNCT06998069Phase 3
• Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO TrialRecruitingNCT06995508Phase 2
• Phase 1/2 Study of ETX-636 in Participants With Advanced Solid TumorsRecruitingNCT06993844Phase 1/2
• High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck CancerRecruitingNCT06992427Phase 3
• SYS6002 Plus JMT101 and Enlonstobart Injection in Participants With HNSCCNot yet recruitingNCT06989671Phase 2
• Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck CancerRecruitingNCT06980038Phase 2
• Cetuximab + Tislelizumab + Chemotherapy in the Treatment of Unresectable LA HNSCCRecruitingNCT06978829Phase 2
• Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid TumorsRecruitingNCT06975410Phase 1/2
• DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid TumorsRecruitingNCT06953089Phase 2
• Immune Biomarker Study for Cisplatin-ineligible Patients Receiving Chemoradiotherapy With DocetaxelRecruitingNCT06947668
• AK129 Combination Therapy for Advanced Solid TumorsRecruitingNCT06943820Phase 1/2
• A Study of MT-4561 in Patients With Various Advanced Solid TumorsRecruitingNCT06943521Phase 1/2
• Dalpicilib Plus Cetuximab Compared With Cetuximab Alone in HPV-negative, Anti-PD-1-resistant R/M HNSCCRecruitingNCT06935188Phase 2
• Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck CancerRecruitingNCT06929468
• High-Resolution PET-CT Imaging for Surgical Margin VisualizationRecruitingNCT06915454Not applicable
• ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the OropharynxRecruitingNCT06915038Not applicable
• Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck CancerRecruitingNCT06914999Early Phase 1
• Molecular-Based Selection of Patients with Head and Neck Squamous Cell Carcinoma: Biomarker AnalysisRecruitingNCT06905145
• The Efficacy and Safety of Pucotenlimab Combined With TP Chemotherapy as Neoadjuvant Therapy for Locally Advanced HNSCCNot yet recruitingNCT06895369Phase 2
• A Prospective, Multicenter, Multicohort Phase II Study: Evaluating the Efficacy and Safety of Preoperative Neoadjuvant Treatment With a PD-1 Inhibitor in Combination With Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell CarcinomaNot yet recruitingNCT06894459Phase 2
• A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) ProductsEnrolling by invitationNCT06885424
• Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral LesionsNot yet recruitingNCT06876038Phase 2
• Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients.Not yet recruitingNCT06875791Phase 1/2
• Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.RecruitingNCT06869473Phase 2
• TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell CancerRecruitingNCT06868433Phase 1
• Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal CancerNot yet recruitingNCT06861712Phase 2
• Heterogeneity of Oral Squamous Cell Carcinoma Analysis by Single Cell RNA SequencingNot yet recruitingNCT06861036Not applicable
• Study of Cetuximab Plus/Minus Weekly Paclitaxel After Progression To First-Line Pembrolizumab Plus Platinum-5FU in Subjects With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck.RecruitingNCT06856213Phase 2
• Exercise Therapy in Head and Neck Squamous Cell Carcinoma (HNSCC)Not yet recruitingNCT06839014Not applicable
• Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal ReconstructionRecruitingNCT06831149Phase 2
• Towards Cure Via Only Ultra-short ICB in CSCCRecruitingNCT06823479Phase 2
• Patients With Human Papillomavirus-associated Head and Neck Cancer for the Discovery of Predictive Biomarkers to Guide Clinical InterventionRecruitingNCT06821243
• Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerRecruitingNCT06819228Phase 1
• Reconstruction of Cervical Lymphatic System During Head and Neck Squamous Cell Carcinoma SurgeryNot yet recruitingNCT06815705Not applicable
• Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06814067Phase 2
• Decisional Regret in Open Partial Horizontal LaryngectomyRecruitingNCT06805071
• A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects With HPV Positive HNSCC.RecruitingNCT06797986Phase 1/2
• [68Ga]Ga-FAPI-46 in Staging of Head and Neck CarcinomasRecruitingNCT06794372Phase 2
• A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid TumorsRecruitingNCT06789172Phase 1
• FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCCRecruitingNCT06788990Phase 2/3
• A Study of Evofosfamide in Combination with Zalifrelimab and BalstilimabRecruitingNCT06782555Phase 1/2
• A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H MutationRecruitingNCT06778863Phase 1
• Nano-crystalline Megestrol Acetate for Adjuvant Treatment in High-risk Head and Neck Squamous Cell Carcinoma After Surgery.Not yet recruitingNCT06772428Phase 3
• A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT06769698Phase 2
• Phase II Clinical Trial of De-Intensified Therapy in Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT06759155Phase 2
• A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid TumorsRecruitingNCT06747585Phase 1/2
• Intratumoral Lidocaine Injection Before Oropharyngeal Cancer SurgeryRecruitingNCT06747390Phase 1
• Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and NeckRecruitingNCT06744296
• Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck CancerRecruitingNCT06736379Phase 1
• Preoperative Tislelizumab -Cetuximab - Chemotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab -Cetuximab for Resectable, Locally Recurrent Oral and Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT06728618Phase 2
• The Value of CEUS in Assessing the Response of Cervical Lymph Nodes After NACI for HNSCCRecruitingNCT06727162
• Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed TomograhyNot yet recruitingNCT06726512Not applicable
• Intra-arterial Chemotherapy Combined with Radiotherapy and Immunotherapy for HNSCCRecruitingNCT06725498Phase 2
• Efficacy and Safety of a Third-Course of Neoadjuvant Immunochemotherapy Combined With SBRT in Locally Advanced Head and Neck Squamous Cell Carcinoma Patients With Stable Disease After Two Treatment Courses: A Single-Arm Exploratory StudyNot yet recruitingNCT06722495Not applicable
• Trilaciclib in Preventing Hematopoietic Suppression in Patients with Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06714266Phase 2
• A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid TumorsRecruitingNCT06700070Early Phase 1
• Neoadjuvant Therapy of Targeted Immunotherapy Combined With Chemotherapy for Locally Advanced HNSCCNot yet recruitingNCT06699498Phase 2
• A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant MetastasesRecruitingNCT06699212Phase 3
• Pembrolizumab in Combination with Flutamide Treatment for Recurrence / Metastasis HNSCCNot yet recruitingNCT06694350Phase 2
• Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCCRecruitingNCT06693323Phase 2
• Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant TumorsEnrolling by invitationNCT06690216Phase 1/2
• PDO Based Drug Sensitive Test in R/M HNSCCRecruitingNCT06686342
• A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 ExpressionRecruitingNCT06682793Phase 1/2
• Enhancing Oral Cancer AwarenessRecruitingNCT06682494Not applicable
• Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-γ Expression and CTM Correlation With DS-SACA ChipRecruitingNCT06678724
• Arabic PRO Measures for Head and Neck Cancer Radiotherapy.RecruitingNCT06662929
• Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or RadiationRecruitingNCT06662058Not applicable
• Thermotherapy in Addition to SOC Palliative RadiotherapyRecruitingNCT06659146Not applicable
• First in Human Study of TUB-030 in Patients With Advanced Solid TumorsRecruitingNCT06657222Phase 1/2
• Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT06648096Phase 1/2
• Neoadjuvant Toripalimab + Chemotherapy ± Cetuximab in Locally Advanced Head and Neck Squamous Cell Carcinoma (Neo-ICT)Not yet recruitingNCT06647563Phase 3
• PET-imaging of Two Vartumabs in Patients With Solid TumorsRecruitingNCT06645808Early Phase 1
• Study of TPEx Followed by a Maintenance With Avelumab and Cetuximab in First Line Recurrent or Metastatic Squamous Cell Carcinoma of the H&NRecruitingNCT06640725Phase 2
• Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP TrialRecruitingNCT06636734Phase 2
• Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral CancerRecruitingNCT06627270Phase 2
• Neck Observation or Elective Neck Dissection in cT1N0M0 OSCCRecruitingNCT06623266Not applicable
• SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and HypopharynxRecruitingNCT06611137Phase 2
• Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell CarcinomaRecruitingNCT06606028
• A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)RecruitingNCT06601335Phase 3
• Clinical Outcomes of Thoracodorsal Artery Flap in Oral and Maxillofacial ReconstructionNot yet recruitingNCT06599801
• ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid TumoursRecruitingNCT06597721Phase 1
• A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCCRecruitingNCT06597565Phase 2
• Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous TreatmentRecruitingNCT06589804Phase 3
• Phase 1 Clinical Trial of FluBHPVE6E7 Immunotherapy for HPV16-Associated Oropharyngeal CancerRecruitingNCT06589609Phase 1
• Surgery and Reducing Ionizing Radiation of the Unknown PrimaryNot yet recruitingNCT06578871Phase 2
• Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell CarcinomaRecruitingNCT06576180
• Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell CarcinomaRecruitingNCT06575322
• De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCCRecruitingNCT06572514Phase 1/2
• Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell CarcinomasRecruitingNCT06540443Phase 1
• AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06537011Phase 2
• Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid TumorsRecruitingNCT06535607Phase 2
• Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical StudyRecruitingNCT06534762Phase 2
• Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck CancerRecruitingNCT06532279Phase 2
• A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection ± Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06530914Phase 2
• Blood Biomarkers Based Screening for HPV-driven OPCNot yet recruitingNCT06528353Not applicable
• SMP-3124LP in Adults With Advanced Solid TumorsRecruitingNCT06526819Phase 1/2
• A Study of DM005 in Patients With Advanced Solid TumorsRecruitingNCT06515990Phase 1/2
• A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06509997Phase 2
• AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic TherapyRecruitingNCT06494995Phase 2
• Induction IBI110 and Sintilimab with Chemotherapy in LA HNSCCRecruitingNCT06494943Phase 1/2

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