Spondylolisthesis clinical trials
The registry lists 227 studies for Spondylolisthesis across more than 10 countries. 43 are recruiting or about to start. 99 of them are mainly about Spondylolisthesis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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A study of drug A after surgery for early breast cancer
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Status
Who runs them
Zimmer Biomet (6) · Ohio State University (5) · Aesculap AG (5) · Baxano Surgical, Inc. (4) · NuVasive (4) · K2M, Inc. (3) · Nova Scotia Health Authority (3) · Medicrea International (3)
What is being tested here
Drugs under test in Spondylolisthesis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Deamino Arginine Vasopressin | 1 | 0 | 1 |
| Vancomycin | 1 | 0 | 1 |
| Ropivacaine | 0 | 1 | 3 |
| Liposomal Bupivacaine | 0 | 0 | 2 |
| Bupivacaine | 0 | 0 | 2 |
| Teriparatide | 0 | 0 | 1 |
| Pregabalin | 0 | 0 | 1 |
| Rexlemestrocel-l | 0 | 0 | 1 |
| Ketamine | 0 | 0 | 1 |
| Denosumab | 0 | 1 | 1 |
Drug classes tested here Local anesthetics 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Effects of Orthosis & Exercise on Spondylolisthesis · Medipol University
- Nov 2026Intercorporal Bone Graft Measurement Study · Rijnstate Hospital
- Dec 2026Evaluation of NB1 Bone Graft Following Lumbar Interbody Arthrodesis · Bone Biologics Corp
- Jan 2027Titanium vs. PEEK Fusion Devices in 1 Level TLIF · Twin Cities Spine Center
- Feb 2027Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery · John O'Toole
- Jun 2027Studying Melatonin and Recovery in Teens · Stanford University
- Aug 2027ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion · University Hospital, Bordeaux
- Sep 2027Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age Patient · Wuhan Union Hospital, China
- Sep 2027The Course of Hip Flexion Weakness Following LLIF or ALIF · Rush University Medical Center
- Sep 2027Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery · Taipei Veterans General Hospital, Taiwan
Who these studies take
Of the 27 Spondylolisthesis studies recruiting now, 11 (41%) set no upper age limit and 8 (30%) stop at 75 or younger. 7 (26%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (19%) | 5 (19%) |
| 18 | 22 (81%) | 22 (81%) |
| 30 | 22 (81%) | 22 (81%) |
| 40 | 23 (85%) | 23 (85%) |
| 50 | 25 (93%) | 25 (93%) |
| 65 | 25 (93%) | 25 (93%) |
| 75 | 21 (78%) | 21 (78%) |
| 85 | 14 (52%) | 14 (52%) |
Across all 227 studies, recruiting or not: 27% stop at 75 or younger and 8% at 65; 11% take children; <1% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Spondylolisthesis studies take
Of 61 interventional studies with no phase under Spondylolisthesis, half reached primary completion within 46 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 46 mo16–65 · 61 studies | — | 38 mo12–63 · 42 studies |
| Observational | 63 mo32–93 · 37 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper PrimeTerminatedNov 10, 2026NCT06704906
Newly registered2
- Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar SurgeryOct 26, 2026NCT07893938
- Nurse-Led Early Standing Exercise After Lumbar Fusion in Older AdultsOct 13, 2026NCT07870993
Studies
Recruiting first, then most recently updated. Showing 50 of 227. Browse all 227 → or search them.
- Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman DeviceRecruitingNCT06355791Not applicable1 country
- Thoracic-Lumbar Arthrodesis- Implanet JazzRecruitingNCT053661401 country
- Studying Melatonin and Recovery in TeensRecruitingNCT06093477Not applicable1 country
- Kore Fiber PLF StudyNot yet recruitingNCT07868510Not applicable1 country
- Evaluation of NB1 Bone Graft Following Lumbar Interbody ArthrodesisRecruitingNCT03810573Not applicable1 country
- The Course of Hip Flexion Weakness Following LLIF or ALIFEnrolling by invitationNCT042041351 country
- PMCF Study Fortilink-TS TiRecruitingNCT078347361 country
- PMCF Study Fortilink-TC TiRecruitingNCT078349311 country
- Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant Human Bone Morphogenetic Protein-2 or ViviGen®RecruitingNCT05238740Not applicable1 country
- Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF)Not yet recruitingNCT07775729Not applicable
- Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set RecoverNot yet recruitingNCT07766824Early Phase 11 country
- Effects of Orthosis & Exercise on SpondylolisthesisRecruitingNCT06989138Not applicable1 country
- Advanced SPinal Innovations With Robotics and Enabling Technology RegistryRecruitingNCT050711441 country
- PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling MaterialsRecruitingNCT076154911 country
- Comparative Analysis of Two Transforaminal Lumbar Interbody Fusion (TLIF) Procedures in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled TrialRecruitingNCT07588555Not applicable1 country
- AI-Powered Scoliosis Auto-Analysis System Multicenter Development and ValidationsRecruitingNCT051461931 country
- Effect of Hip Extension Mobilization on Functional Disability in Patients With SpondylolisthesisNot yet recruitingNCT07547969Not applicable
- Regional Anesthesia in Minimally Invasive Lumbar Spine SurgeryRecruitingNCT05029726Phase 41 country
- Advanced Materials Science in XLIF StudyEnrolling by invitationNCT036494901 country
- Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar SpondylolisthesisRecruitingNCT072897371 country
- Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF ProceduresEnrolling by invitationNCT04684901Not applicable1 country
- Rate of Bone Union After Surgery With Stand-alone FibergraftNot yet recruitingNCT071990751 country
- A Prospective Analysis of the Efficacy of Allosync Expand and Autograft Bone Graft in Open Lumbar Spinal FusionEnrolling by invitationNCT064151101 country
- Titanium vs. PEEK Fusion Devices in 1 Level TLIFEnrolling by invitationNCT05691062Phase 41 country
- A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine SurgeryNot yet recruitingNCT07028099Not applicable
- Short-term Clinical Outcome of Cortical Bone Trajectory Compared With the Traditional "Open" and Minimal Invasive Posterior Lumbar Interbody FusionRecruitingNCT055384161 country
- ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid FusionRecruitingNCT069508531 country
- Self-rehabilitation At Home After LumbaR Arthrodesis (SAHARA)RecruitingNCT06129682Not applicable1 country
- Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar SpondylolisthesisNot yet recruitingNCT06799975Not applicable1 country
- Long-term Reoperations After Lumbar Spinal Stenosis SurgeryRecruitingNCT064070631 country
- Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion ProcedureRecruitingNCT056484741 country
- Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age PatientEnrolling by invitationNCT065914421 country
- Midline Versus Paramedian Approaches in Treating Degenerative Lumbar SpondylolisthesisRecruitingNCT03344484Not applicable1 country
- Anterior vs Posterior Surgery for Lumbar Isthmic SpondylolisthesisRecruitingNCT057010461 country
- Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar FusionNot yet recruitingNCT06255366Phase 4
- Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in TLIFRecruitingNCT06265038Not applicable1 country
- Spinal Stenosis and Listhesis Treated With Percutaneous Interspinous Spacer: a Non-surgical TrialRecruitingNCT05527145Not applicable1 country
- Safety and Efficacy Assessment of Using the zLOCK Facet Stabilization SystemRecruitingNCT05266521Not applicable2 countries
- The Spine PROMCO StudyRecruitingNCT059638151 country
- OSTEOAMP Lumbar Fusion Intra-Patient Controlled StudyRecruitingNCT05405374Not applicable1 country
- Incidence of Lumbar Spondylolisthesis in Patients Candidate for TKRNot yet recruitingNCT05464134
- A RCT of UBE vs. MIS-TLIF in Lumbar SpondylolisthesisNot yet recruitingNCT05480267Not applicable
- Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine SurgeryRecruitingNCT03883022Not applicable1 country
- Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper PrimeTerminatedNCT067049061 country
- Ultrasound-Guided Erector Spinae Plane Block to Evaluate Anesthetic Requirement in Lumbar Spondylolisthesis SurgeryCompletedNCT07514806Not applicable1 country
- Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar SurgeryCompletedNCT07893938Not applicable1 country
- The European Robotic Spinal Instrumentation (EUROSPIN) StudyCompletedNCT033989157 countries
- SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw FusionActive, not recruitingNCT03570801Not applicable2 countries
- Evaluation of Balance Using the Biodex Balance System Among Different Subcategories of Low Back PainCompletedNCT07242976Not applicable1 country
- Post-surgery Muscle Preservation and Pain Reduction Through Blood Flow Restriction Training in Orthopedic Spinal SurgeryCompletedNCT06962683Not applicable1 country