Sickle Cell Trait clinical trials

The registry lists 43 studies for Sickle Cell Trait across more than 10 countries. 11 are recruiting or about to start. 19 of them are mainly about Sickle Cell Trait (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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A study of drug A after surgery for early breast cancer

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Drug B with hormone therapy in advanced breast cancer

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· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

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Status

Completed: 21
Recruiting: 8
Active, not recruiting: 4
Terminated: 3
Not yet recruiting: 3
Status unknown: 3

Phase

Phase 3: 6
Phase 1: 6
Phase 2: 2
Early Phase 1: 1

Where

United States: 29
France: 8
Italy: 5
Lebanon: 5
Canada: 5
Kenya: 4

Who runs them

National Heart, Lung, and Blood Institute (NHLBI) (4) · Pfizer (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Hospices Civils de Lyon (2) · UConn Health (2) · Columbia University (2) · Novartis Pharmaceuticals (2) · Forma Therapeutics, Inc. (2)

What is being tested here

Drugs under test in Sickle Cell Trait studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Crizanlizumab	1	2	2
Fostamatinib	1	0	1
Etavopivat	0	1	2
Inclacumab	0	2	2
Ticagrelor	0	0	1
PfSPZ Challenge	0	0	1
Granulocyte Colony-Stimulating Factor	0	1	1
Siplizumab	0	0	1

Coming up

3phase 3 studies under way

4studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 4

Dec 2026Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT) · National Alliance for Sickle Cell Centers
May 2027Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease · National Heart, Lung, and Blood Institute (NHLBI)
Sep 2027CHOICES3: Sickle Cell Disease Parenting CHOICES · University of Florida
Nov 2027Transfusion Exchanges and Cognition in Sickle Cell Disease · Centre Hospitalier St Anne

Who these studies take

Of the 8 Sickle Cell Trait studies recruiting now, 2 (25%) set no upper age limit and 4 (50%) stop at 75 or younger. 3 (38%) take children under 18. 1 (13%) are for women only and 0 (0%) for men only; 5 (63%) take healthy volunteers.

Recruiting studies that take each age, of 8
Age	Women	Men
10	1 (13%)	1 (13%)
18	7 (88%)	7 (88%)
30	6 (75%)	6 (75%)
40	6 (75%)	6 (75%)
50	7 (88%)	6 (75%)
65	6 (75%)	5 (63%)
75	4 (50%)	3 (38%)
85	4 (50%)	3 (38%)

Across all 43 studies, recruiting or not: 37% stop at 75 or younger and 35% at 65; 42% take children; 7% are for women only and 5% for men only; 42% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 43 of 43. search them.