An observational study in Sickle Cell Trait, sponsored by National Alliance for Sickle Cell Centers. Recruiting at 8 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-07.
Sponsored by National Alliance for Sickle Cell Centers · Observational
The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.
43 studies on the registry are indexed under Sickle Cell Trait; 11 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 109 across 20 observational studies indexed under Sickle Cell Trait.
Browse Sickle Cell Trait studies →This is the only study on the registry with National Alliance for Sickle Cell Centers as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Adults aged 18 and older with sickle cell trait.
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Exclusion Criteria:
Other: Biologic Specimen Collection
Participants will have blood and urine collected at Baseline
Hemoglobin variant quantification
Determine range of variability in baseline %HbS in SCT subjects and relationship of baseline %HbS to markers of hemolysis (LDH, reticulocytes, haptoglobin), coagulopathy (D-dimer), and renal disease (urine albumin/creatinine ratio)
Time frame: Through study completion, an average of 2 years
Red blood cell rheology
Identify range of variation in baseline RBC rheological parameters in SCT subjects and relationship to %HbS, other baseline clinical parameters
Time frame: Through study completion, an average of 2 years
Natural History
Evaluate the frequency of hemolysis * Evaluate potential for and progression of chronic kidney disease and albuminuria * Evaluate the relative risk of thrombosis based on medical history * Evaluate the prevalence of episodes of pain or exercise-related symptoms
Time frame: Through study completion, an average of 2 years
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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