An interventional study of Blood sampling in Sickle Cell Disease and Sickle Cell Trait, sponsored by Hanane EL KENZ. Completed at 2 sites in Belgium. Per ClinicalTrials.gov, last updated 2021-01-28.
Sponsored by Hanane EL KENZ · Not applicable, Interventional, and Diagnostic
Bearers of the sickle cell allele (S) are currently eligible for blood donations in Belgium. As blood donors are not tested for this allele, their heterozygous status is unknown. However, guidelines recommend to transfuse sickle cell patients with blood that is negative for the 'S' hemoglobin. To the investigator's knowledge, no study has been conducted to evaluate the impact of transfusion with blood originating from heterozygous donors on the transfusion performance and the improvement of clinical status of the sickle cell disease patients.
All patients with sickle cell disease within the CHU Brugmann and the Queen Fabiola Children's Hospital (HUDERF)
Exclusion Criteria:
None
Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)
Procedure: Blood sampling
Blood donor not bearer of the sickle cell disease allele (HbAA genotype)
Procedure: Blood sampling
Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)
Procedure: Blood sampling
Blood donor not bearer of the sickle cell disease allele (HbAA genotype)
Procedure: Blood sampling
Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)
Procedure: Blood sampling
Blood donor not bearer of the sickle cell disease allele (HbAA genotype)
Procedure: Blood sampling
Extra blood samples taken for laboratory analysis
Hemoglobin level -patient
Hemoglobin level (g/dL)
Time frame: 1 hour before blood transfusion
Hemoglobin level -patient
Hemoglobin level (g/dL)
Time frame: 1 hour after blood transfusion
% of 'S' type hemoglobin -patient
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour before blood transfusion
% of 'S' type hemoglobin -patient
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour after blood transfusion
Hemoglobin level - transfused blood
Hemoglobin level (g/dL)
Time frame: 1 hour before blood transfusion
% of 'S' type hemoglobin -transfused blood
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour before blood transfusion
Transfusion yield
Computed by means of a formula taking the level of hemoglobin, the % of 'S' type hemoglobin and the body surface into account.
Time frame: 1 hour after blood transfusion
Medical complications
List of medical complications having occured after a surgery. Applicable only to the 'transfusion prior to surgery' groups.
Time frame: 1 month
Length of stay
Length of stay within the hospital. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Length of stay post transfusion
Length of stay within the hospital after a blood transfusion. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Number of blood transfusions
Number of blood transfusions. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Hospital re-admission
Hospital re-admission. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Mortality rate
Mortality rate. Applicable only to the 'acute transfusion' groups
Time frame: 1 month.
Plan to share: No
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This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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Hanane EL KENZ