Drug
Thiotepa clinical trials
Also written Tepadina, WR 45312, Thioplex and SH-105.
- studies test it
- 130
- open now
- 27
- in phase 3
- 14
- first study started
- 1995
Keep track of what changes. Save the Thiotepa studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Combined with it in one product
Studies by the year they started
130 studies that test it; most in 2005 (11)
| Year | Studies |
|---|---|
| 1995 | 3 |
| 1996 | 1 |
| 1997 | 9 |
| 1998 | 5 |
| 1999 | 4 |
| 2000 | 2 |
| 2001 | 3 |
| 2002 | 2 |
| 2003 | 3 |
| 2004 | 2 |
| 2005 | 11 |
| 2006 | 5 |
| 2007 | 7 |
| 2008 | 2 |
| 2009 | 10 |
| 2010 | 3 |
| 2011 | 2 |
| 2012 | 1 |
| 2013 | 4 |
| 2014 | 4 |
| 2015 | 4 |
| 2016 | 2 |
| 2017 | 2 |
| 2018 | 7 |
| 2019 | 3 |
| 2020 | 3 |
| 2021 | 6 |
| 2022 | 4 |
| 2023 | 1 |
| 2024 | 1 |
| 2025 | 6 |
| 2026 | 8 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 30
- Phase 2
- 94
- Phase 3
- 14
- No phase
- 6
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 0 · Other 130
Fred Hutchinson Cancer Center (13) · Memorial Sloan Kettering Cancer Center (11) · Children's Oncology Group (9) · M.D. Anderson Cancer Center (9) · St. Jude Children's Research Hospital (8) · Masonic Cancer Center, University of Minnesota (5) · St. Anna Kinderkrebsforschung (4) · Samsung Medical Center (4)
Often tested with
Tested in the same studies.
Fludarabine (50) · Cyclophosphamide (48) · Melphalan (47) · Busulfan (34) · Carboplatin (30) · Etoposide (29) · Filgrastim (18) · Fludarabine phosphate (14)
Studies
Open first, then newest update. How each study uses Thiotepa is read from its arms, and is right about nine times in ten.
Testing it · 130
- Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)RecruitingPhase 2Fred Hutchinson Cancer CenterNCT03970096Written as Thiotepa
- A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCTRecruitingPhase 2Children's Oncology GroupNCT04684368Written as Thiotepa
- Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant DisordersRecruitingPhase 2Fred Hutchinson Cancer CenterNCT03980769Written as Thiotepa
- Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic LeukaemiaRecruitingPhase 2/3St. Anna KinderkrebsforschungNCT01949129Written as Thiotepa
- CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell TransplantRecruitingPhase 2Washington University School of MedicineNCT06687772Written as Thiotepa
- CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and LymphomaRecruitingPhase 1St. Jude Children's Research HospitalNCT07257419Written as Thiotepa
- Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI.Not yet recruitingPhase 2Tianjin Medical University Cancer Institute and HospitalNCT07778940Written as Thiotepa
- Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic MalignanciesRecruitingPhase 1Sawa Ito, MDNCT07565220Written as Thiotepa
- Autologous Stem Cell Transplantation in Patients With Systemic SclerosisRecruitingPhase 2Paul SzabolcsNCT03630211Written as Thiotepa
- T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other AnemiasRecruitingPhase 1/2Paul SzabolcsNCT03653338Written as Thiotepa
- Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell DiseaseRecruitingPhase 2St. Jude Children's Research HospitalNCT07616154Written as Thiotepa
- Cord Blood Transplantation in Children and Young Adults With Blood CancerRecruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT07566377Written as Thiotepa
- TBF Conditioning Regimen for Haploidentical Stem Cell Transplantation in Elderly AML Patients in First Complete RemissionNot yet recruitingNot applicableShanghai General Hospital, Shanghai Jiao Tong University School of MedicineNCT07563920Written as Thiotepa
- Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell TransplantationRecruitingPhase 2M.D. Anderson Cancer CenterNCT06807606Written as Thiotepa
- The Safety and Efficacy of the Regimen of Thiotepa + Fludarabine +Granulocyte Colony-Stimulating Factor+ Cytarabine + Busulfan in Single Unrelated Umbilical Cord Blood TransplantationNot yet recruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT07441967Written as Thiotepa
- Thiotepa in Combination With Pirtobrutinib (a BTK Inhibitor) and Sintilimab (a PD-1 Inhibitor) for Frail or Relapsed/Refractory Primary or Secondary Central Nervous System LymphomaRecruitingPhase 2Zhejiang Cancer HospitalNCT07416890Written as Thiotepa, Pirtobrutinib , Sintilimab(TPS)
- Lung and Bone Marrow Transplantation for Lung and Bone Marrow FailureRecruitingPhase 1/2Paul SzabolcsNCT03500731Written as Thiotepa
- Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTRecruitingPhase 2Paul SzabolcsNCT01962415Written as Thiotepa
- Preconditioning With a Combination of Thiotepa, Cyclophosphamide, and Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of NK/T-Cell LymphomaNot yet recruitingPhase 2Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineNCT07276737Written as Thiotepa
- A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）RecruitingNot applicableRuijin HospitalNCT07191431Written as Selinexor+Orelabrutinib+Methotrexate/Thiotepa/Temozolomide
See all 130 studies that test Thiotepa →
Given in every arm · 44 — Thiotepa is usual care beside what is tested
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk NeuroblastomaRecruitingPhase 3National Cancer Institute (NCI)NCT06172296Written as Thiotepa
- Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)RecruitingPhase 3Children's Oncology GroupNCT03126916Written as Thiotepa
- Allogeneic ORCA-Q Stem Cell Transplant for the Treatment of Relapsed and Refractory High Risk Multiple MyelomaNot yet recruitingPhase 1University of California, DavisNCT07759102Written as Thiotepa
- Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDSRecruitingPhase 2/3M.D. Anderson Cancer CenterNCT04708054Written as Thiotepa
- Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic DiseasesRecruitingPhase 2Fred Hutchinson Cancer CenterNCT06013423Written as Thiotepa
- Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post ConsolidationRecruitingEarly Phase 1C17 CouncilNCT06942039Written as Thiotepa
- TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic MalignanciesRecruitingPhase 1St. Jude Children's Research HospitalNCT07052370Written as Thiotepa
- Autologous Stem Cell Transplantation for Crohn's DiseaseRecruitingPhase 1/2Paul SzabolcsNCT00692939Written as Thiotepa
- Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk NeuroblastomaRecruitingPhase 2Masonic Cancer Center, University of MinnesotaNCT02605421Written as Thiotepa
- IS-free Treg HaploHCTRecruitingPhase 1Dana-Farber Cancer InstituteNCT04678401Written as Thiotepa
- Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic SyndromeSuspendedPhase 1City of Hope Medical CenterNCT06195891Written as Thiotepa
- Itacitinib for the Prevention of Graft Versus Host DiseaseActive, not recruitingPhase 2M.D. Anderson Cancer CenterNCT04859946Written as Thiotepa
- Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell TransplantActive, not recruitingPhase 2Fred Hutchinson Cancer CenterNCT03779854Written as Thiotepa
- TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic MalignanciesActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT03849651Written as Thiotepa
- ABBA CORD: dCBT w/ Abatacept for aGVHD ProphylaxisSuspendedPhase 2Leland MethenyNCT06680661Written as Thiotepa
- Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating Patients With Blood Cancer Undergoing Donor Stem Cell TransplantActive, not recruitingPhase 2M.D. Anderson Cancer CenterNCT02861417Written as Thiotepa
- Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic SyndromeActive, not recruitingPhase 3Children's Oncology GroupNCT05457556Written as Thiotepa
- Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic SyndromesActive, not recruitingPhase 2Fred Hutchinson Cancer CenterNCT03399773Written as Thiotepa
- Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk NeuroblastomaCompletedPhase 2National Cancer Institute (NCI)NCT03786783Written as Thiotepa
- Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHDCompletedPhase 2Fred Hutchinson Cancer CenterNCT02220985Written as Thiotepa
Showing 20 of 44.
As the comparator · 4 — what is tested is compared with Thiotepa
- Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft TransplantationRecruitingPhase 2Nantes University HospitalNCT06252870Written as Thiotepa
- Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)Active, not recruitingPhase 1/2St. Jude Children's Research HospitalNCT03597594Written as Thiotepa
- CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell TransplantActive, not recruitingPhase 1/2Diane GeorgeNCT02061800Written as Thiotepa
- Combination Chemotherapy in Treating Patients With High-Risk Breast CancerCompletedPhase 2City of Hope Medical CenterNCT00004092Written as thiotepa
Codes
What other systems call Thiotepa · ClinicalTrials.gg INT008307
- MeSH (NLM) D013852ThiotepaConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 905Z5W3GKHTHIOTEPAConfirmed FDA, NLM, Wikidata
- RxNorm 10473Confirmed FDA, Wikidata
- Wikidata Q416507thiotepaConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C875ThiotepaOne source FDA
- DrugBank DB04572One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D013852 | Thiotepa | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 905Z5W3GKH | THIOTEPA | Confirmed FDA, NLM, Wikidata |
| RxNorm | 10473 | — | Confirmed FDA, Wikidata |
| Wikidata | Q416507 | thiotepa | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C875 | Thiotepa | One source FDA |
| DrugBank | DB04572 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.