An interventional study of Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade and Face-Down Postoperative Positioning in Macular Hole, sponsored by Lahore General Hospital. Active, not recruiting at 1 site in Pakistan. Open to participants aged 52 Years to 84 Years. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Lahore General Hospital · Not applicable, Interventional, and Treatment
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade. The study was conducted at the Department of Ophthalmology, Lahore General Hospital, Lahore. A total of 52 male and female patients aged 52-84 years with full-thickness macular holes were included.
All patients underwent 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery after staining with 0.05% Brilliant Blue. Patients were divided into two groups according to postoperative positioning. One group performed postoperative face-down posturing, whereas the other group did not perform face-down posturing. The study examined whether successful closure of large macular holes could be achieved without postoperative face-down positioning after surgery with SF6 gas tamponade.
Patients were followed on postoperative days 1, 7, 30, and 90. The main outcome was anatomical closure of the macular hole, which was assessed using optical coherence tomography (OCT). Successful treatment was defined as complete anatomical closure of the macular hole. The outcomes of patients who performed face-down posturing were compared with those who did not perform postoperative posturing to determine whether face-down positioning was necessary following surgery for macular holes larger than 400 micrometres.
139 studies on the registry are indexed under Retinal Perforations; 22 are open to participants now.
This study's enrollment of 52 is close to the median of 50 across 94 interventional studies indexed under Retinal Perforations.
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Exclusion Criteria:
Secondary MH causes
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients underwent 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery after staining with 0.05% Brilliant Blue, followed by SF6 gas tamponade. After surgery, patients performed postoperative face-down posturing.
Procedure: Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade · Behavioral: Face-Down Postoperative Positioning
Patients underwent the same 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery after staining with 0.05% Brilliant Blue, followed by SF6 gas tamponade. Patients did not perform postoperative face-down posturing.
Procedure: Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade · Behavioral: No Face-Down Postoperative Positioning
Patients underwent 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery with SF6 gas tamponade.
Patients performed face-down posturing after surgery according to the postoperative instructions.
Patients were managed without postoperative face-down posturing.
Anatomical Closure of the Macular Hole on OCT
Proportion of participants with complete anatomical closure of the macular hole on optical coherence tomography.
Time frame: 3 months after surgery.
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Lahore General Hospital