Respiratory Distress Syndrome clinical trials
The registry lists 1,387 studies for Respiratory Distress Syndrome across more than 10 countries. 282 are recruiting or about to start. 905 of them are mainly about Respiratory Distress Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its 4 narrower conditions too, such as Respiratory Distress Syndrome, Newborn: 1,551 studies, 313 open.
ClinicalTrials.gov finds 1,935 studies for Respiratory Distress Syndrome. How that becomes 1,386 here
This page counts the studies the registry files under Respiratory Distress Syndrome, and those it files under no condition that list Respiratory Distress Syndromethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,935Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −164Filed under a narrower condition, counted on its own pageRespiratory Distress Syndrome, Newborn 95 · Transient Tachypnea of the Newborn 27 · Respiratory Distress Syndrome In Premature Infants 18 · Hyaline Membrane Disease 14
- −148List Respiratory Distress Syndrome as a condition, but the registry did not file them under itMost often written as “ARDS (Acute Respiratory Distress Syndrome)” (48), “COVID-19 Acute Respiratory Distress Syndrome” (43), and “Respiratory Distress Syndrome in Premature Infant” (22). The registry filed them under other conditions only, most often Acute Lung Injury (56) and COVID-19 (47).
- −237Match it another way160 name it in the title, 8 in a keyword, and 69 by a synonym or other text the search reads.
- 1,386The count on this page42 of them list Respiratory Distress Syndrome in their own words; the registry filed them under no condition.
Get an email when these change. Save the Respiratory Distress Syndrome studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Assistance Publique - Hôpitaux de Paris (33) · Southeast University, China (24) · University Hospital, Clermont-Ferrand (16) · Hospices Civils de Lyon (15) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (11) · University of Minnesota (11) · Policlinico Hospital (11) · Massachusetts General Hospital (11)
What is being tested here
Drugs under test in Respiratory Distress Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 4 | 9 | 14 |
| Poractant alfa | 3 | 0 | 8 |
| Solizmestrocel | 3 | 0 | 3 |
| Bevacizumab | 2 | 0 | 4 |
| Vilobelimab | 2 | 0 | 2 |
| NI-0101 | 2 | 0 | 2 |
| Methylprednisolone | 1 | 2 | 7 |
| Sevoflurane | 1 | 5 | 7 |
| Calfactant | 1 | 3 | 7 |
| Budesonide | 1 | 0 | 7 |
Drug classes tested here Corticosteroids 7 open · Inhaled anesthetics 2 open · Tyrosine kinase inhibitors (TKIs) 2 open · Opioids 2 open · Neuromuscular blockers 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Efficacy and Safety of LEAF-4L6715 for Acute Respiratory Distress Syndrome · Phase 3 · LEAF4Life, Inc.
- May 2027Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome · Phase 3 · Aerogen Pharma Limited
- Jun 2027Study of Xuanbai Shengmai Decoction in the Treatment of Acute Respiratory Distress Syndrome · Phase 3 · Southeast University, China
- Jun 2027A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation · Phase 3 · Shanghai University of Traditional Chinese Medicine
- Jul 2027Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome · Phase 3 · Guy's and St Thomas' NHS Foundation Trust
- Sep 2027Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma · Phase 3 · University Hospital, Strasbourg, France
- Oct 2027To Evaluate the Safety and Potential Therapeutic Activity of JadiCell™, an Investigational Umbilical Cord-Derived Mesenchymal Stem Cell Therapy, in Patients Diagnosed With Acute Respiratory Distress Syndrome (ARDS). · Phase 3 · Breathe Biologics, Inc.
- Nov 2027Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen · Phase 3 · AstraZeneca
- Nov 2027Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS) · Phase 3 · Direct Biologics, LLC
- Nov 2026Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q System · Emory University
Who these studies take
Of the 193 Respiratory Distress Syndrome studies recruiting now, 117 (61%) set no upper age limit and 48 (25%) stop at 75 or younger. 50 (26%) take children under 18. 4 (2%) are for women only and 0 (0%) for men only; 9 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 19 (10%) | 18 (9%) |
| 18 | 155 (80%) | 153 (79%) |
| 30 | 157 (81%) | 153 (79%) |
| 40 | 156 (81%) | 154 (80%) |
| 50 | 157 (81%) | 155 (80%) |
| 65 | 155 (80%) | 153 (79%) |
| 75 | 150 (78%) | 148 (77%) |
| 85 | 136 (70%) | 134 (69%) |
Across all 1,387 studies, recruiting or not: 26% stop at 75 or younger and 22% at 65; 28% take children; 1% are for women only and <1% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Respiratory Distress Syndrome studies take
Of 59 phase 2 interventional studies under Respiratory Distress Syndrome, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1/2 | 19 mo11–23 · 25 studies | — | — |
| Phase 2 | 18 mo9–41 · 59 studies | — | 18 mo9–44 · 31 studies |
| Phase 3 | 29 mo14–46 · 39 studies | — | — |
| Interventional, no phase | 24 mo12–42 · 271 studies | — | 24 mo12–42 · 264 studies |
| Observational | 24 mo12–49 · 231 studies | — | 24 mo12–47 · 225 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting2
- Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib FracturesNov 12, 2026NCT06533904
- Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory FailureOct 15, 2026NCT07463885
Stopped2
- Inhalational (Sevoflurane) Versus Intravenous (Propofol) Sedation in Adults With a Moderate Form of ARDSTerminatedNov 10, 2026NCT05259631
- Electrophysiological Signatures of Cognitive Disorders Related to Intensive Care Unit (ICU) delirium_ BRAINSTORM-EEGTerminatedOct 29, 2026NCT06089538
Newly registered6
- NAVA Use in Preterm Neonates With Respiratory Distress SyndromeNov 9, 2026NCT07926009
- Development and Multicenter Validation of an Explainable System for Neonatal ARDS-Compatible PhenotypingNov 6, 2026NCT07920718
- Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress SyndromeNov 2, 2026NCT07910539
- Early Switch in Moderate ARDSOct 30, 2026NCT07907276
- Clinical Trial of CG-BM1 Allogeneic Human Bone Marrow Mesenchymal Stem Cell Injection in the Treatment of Acute Respiratory Distress SyndromeOct 23, 2026NCT07892950
Show 1 moreShow fewer
- Right Heart Injury Monitoring on ECMOOct 19, 2026NCT07880730
Studies
Recruiting first, then most recently updated. Showing 50 of 1,387. Browse all 1,387 → or search them.
- Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib FracturesRecruitingNCT06533904Not applicable1 country
- Development and Multicenter Validation of an Explainable System for Neonatal ARDS-Compatible PhenotypingNot yet recruitingNCT07920718
- NAVA Use in Preterm Neonates With Respiratory Distress SyndromeRecruitingNCT07926009Not applicable1 country
- Personalized Ventilator Settings for Patients on ECMOEnrolling by invitationNCT07673250Not applicable1 country
- Comparing Surfactant Administration Through Supraglottic Airway and Thin Catheter for Preterm InfantsRecruitingNCT07030270Not applicable1 country
- WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency DepartmentRecruitingNCT07558265Not applicable1 country
- Effect of Transpulmonary MP on Prognosis of Patients With Severe ARDS Treated With VV-ECMORecruitingNCT060622121 country
- Respiratory Distress and Elective Cesarean Section at TermRecruitingNCT068744781 country
- Little Lungs StudyNot yet recruitingNCT06855043Phase 1/21 country
- Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental OxygenRecruitingNCT05624450Phase 339 countries
- Early Switch in Moderate ARDSNot yet recruitingNCT07907276
- Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized AdultsNot yet recruitingNCT06564207Phase 2
- Ventilator Pressure and Optimization of Compliance and HemodynamicsRecruitingNCT06512935Not applicable1 country
- Pulmonary Immune Cell-microbiome Interactions in ARDSRecruitingNCT057952571 country
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)RecruitingNCT05947955Phase 213 countries
- Right Heart Injury Monitoring on ECMONot yet recruitingNCT078807301 country
- Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDSNot yet recruitingNCT07857304
- Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress SyndromeRecruitingNCT05492344Not applicable8 countries
- Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory FailureRecruitingNCT07463885Not applicable1 country
- Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress SyndromeRecruitingNCT06776783Phase 33 countries
- Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDSNot yet recruitingNCT078579281 country
- nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDSNot yet recruitingNCT07869719Not applicable
- Vascular ARDS Recruitment After Inhaled Nitric OxideRecruitingNCT05801224Not applicable1 country
- To Evaluate the Safety and Potential Therapeutic Activity of JadiCell™, an Investigational Umbilical Cord-Derived Mesenchymal Stem Cell Therapy, in Patients Diagnosed With Acute Respiratory Distress Syndrome (ARDS).Not yet recruitingNCT07479043Phase 3
- Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory FailureRecruitingNCT05675345Not applicable1 country
- Application Study of Individualized Mechanical Power Titration Strategy Based on PiCCO (Pulse Index Continuous Cardiac Output) Monitoring Parameters in ARDS PatientsEnrolling by invitationNCT078392341 country
- Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm NeonatesNot yet recruitingNCT07837141Not applicable1 country
- Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDSNot yet recruitingNCT05241067Phase 2
- Early Use of Airway Pressure Release Ventilation (APRV) in ARDSRecruitingNCT04221737Not applicable1 country
- Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDSRecruitingNCT07449572Phase 11 country
- Reverse Trigger Phenotypification and Response to Ventilatory AdjustmentsRecruitingNCT061484671 country
- A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+RecruitingNCT07326215Not applicable1 country
- EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory FailureRecruitingNCT051504831 country
- Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.RecruitingNCT07432191Not applicable1 country
- Multimodal Physiologic State Intelligence StudyEnrolling by invitationNCT078141181 country
- Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care UnitNot yet recruitingNCT07811180Not applicable1 country
- Chest X-Ray Versus Lung Ultrasound in Neonatal PneumoniaNot yet recruitingNCT07807514
- TwichView-guided Atricurium Dose Adjustment TrialRecruitingNCT07807046Not applicable1 country
- Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung RecruitabilityRecruitingNCT064305541 country
- Trunk Inclination, Positive End-expiratory Pressure, and Lung RecruitabilityRecruitingNCT075047311 country
- Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled TrialRecruitingNCT07576660Phase 31 country
- Pre-hospital Ventilation Clinical StudyEnrolling by invitationNCT056044301 country
- Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress SyndromeRecruitingNCT077502881 country
- Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS PatientsNot yet recruitingNCT07798154Not applicable1 country
- Early EIT-Guided PEEP Titration on Pulmonary Physiology in Patients With Moderate-to-Severe ARDS Undergoing Prone Positioning (EIT-PEEP-PRONE)Not yet recruitingNCT07793565Not applicable1 country
- Early Corticosteroids in Severe Influenza PneumoniaNot yet recruitingNCT07786662Phase 31 country
- Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master ProtocolRecruitingNCT06849570Not applicable1 country
- The ARISE Study - Use of Vertical PositioningRecruitingNCT07025421Not applicable1 country
- Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort StudyRecruitingNCT075502181 country