Respiratory Distress Syndrome, Newborn clinical trials
The registry lists 123 studies for Respiratory Distress Syndrome, Newborn across more than 10 countries. 24 are recruiting or about to start. 94 of them are mainly about Respiratory Distress Syndrome, Newborn (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 3 narrower conditions too, such as Transient Tachypnea of the Newborn: 212 studies, 44 open.
Get an email when these change. Save the Respiratory Distress Syndrome, Newborn studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
NICHD Neonatal Research Network (5) · Ain Shams University (5) · Chiesi Farmaceutici S.p.A. (4) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (4) · Rigshospitalet, Denmark (3) · Karolinska Institutet (3) · Keck School of Medicine of USC (2) · University of Alabama at Birmingham (2)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant · Chiesi Poland Sp. z o.o.
- Jan 2027Evaluation of Serial Lung Ultrasound Data After Surfactant Treatments Applied With Different Methods in Preterm Babies · Konya City Hospital
- Mar 2027An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes. · University College Dublin
- May 2027Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure · Connecticut Children's Medical Center
- Aug 2027Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns · Taipei Medical University Shuang Ho Hospital
- Sep 2027Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDS · Assiut University
- Oct 2027Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates · Aga Khan University
Who these studies take
Of the 11 Respiratory Distress Syndrome, Newborn studies recruiting now, 2 (18%) set no upper age limit and 9 (82%) stop at 75 or younger. 11 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (18%) | 2 (18%) |
| 18 | 2 (18%) | 2 (18%) |
| 30 | 2 (18%) | 2 (18%) |
| 40 | 2 (18%) | 2 (18%) |
| 50 | 2 (18%) | 2 (18%) |
| 65 | 2 (18%) | 2 (18%) |
| 75 | 2 (18%) | 2 (18%) |
| 85 | 2 (18%) | 2 (18%) |
Across all 123 studies, recruiting or not: 83% stop at 75 or younger and 83% at 65; 96% take children; 5% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Respiratory Distress Syndrome, Newborn studies take
Of 35 interventional studies with no phase under Respiratory Distress Syndrome, Newborn, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 23 mo13–40 · 35 studies | — | 23 mo13–40 · 35 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 16, 2026.
Newly registered2
- Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress SyndromeNov 2, 2026NCT07910539
- Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature NeonatesOct 23, 2026NCT07891494
Studies
Recruiting first, then most recently updated. Showing 50 of 123. Browse all 123 → or search them.
- Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDSNot yet recruitingNCT07857304
- Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm NeonatesNot yet recruitingNCT07837141Not applicable1 country
- Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical StudyRecruitingNCT07251790Not applicable1 country
- Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant AdministrationRecruitingNCT07442669Not applicable1 country
- Evaluation of Serial Lung Ultrasound Data After Surfactant Treatments Applied With Different Methods in Preterm BabiesRecruitingNCT06880016Not applicable1 country
- Fentanyl and Rocuronium for Tracheal Intubation in NewbornsNot yet recruitingNCT07650552Phase 41 country
- Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory FailureRecruitingNCT06446453Not applicable1 country
- Speed of Lung Inflation During Ventilation of Extremely Preterm InfantsNot yet recruitingNCT07101419Not applicable1 country
- MINImising Total Radiation EXposure in Preterm InfantsRecruitingNCT06975189Phase 21 country
- LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution StudyRecruitingNCT07514481Not applicable1 country
- Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU SettingRecruitingNCT073447141 country
- Impact of Intrahepatic Cholestasis of Pregnancy on Neonatal Respiratory OutcomesEnrolling by invitationNCT066799721 country
- To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted VentilationEnrolling by invitationNCT07235345Not applicable1 country
- "Effectiveness of Delivery Room Bubble CPAP in Preterm Infants With Respiratory DistressEnrolling by invitationNCT07162285Not applicable1 country
- Prophylactic Minimally Invasive Surfactant EvaluationRecruitingNCT06007547Phase 41 country
- Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With SurfactantNot yet recruitingNCT070701671 country
- An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.Not yet recruitingNCT06898801Not applicable1 country
- LUS AT BIRTH IN INFANTS BORN BEFORE 26 WEEKSNot yet recruitingNCT06394583
- Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDSRecruitingNCT06367881Phase 11 country
- NeO2Matic-Pilot TrialNot yet recruitingNCT05629910Not applicable1 country
- Application of Lung Near-Infrared Spectroscopy (NIRS) in Preterm InfantsNot yet recruitingNCT059616701 country
- Infant Respiratory Interface and Accessories Evaluation StudyNot yet recruitingNCT05719298Not applicable1 country
- Infantile NO Replenishment as a New Therapeutic PossibilityRecruitingNCT049148063 countries
- European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and BiobankRecruitingNCT028529283 countries
- Pulmonary Function Using Non-invasive Forced OscillometryActive, not recruitingNCT03346343Not applicable1 country
- Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress SyndromeCompletedNCT07910539Not applicable1 country
- Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature NeonatesCompletedNCT07891494Phase 41 country
- Measuring Diaphragm Electrical Activity in Neonates Using a Smaller Inter-electrode DistanceActive, not recruitingNCT05427929Not applicable1 country
- Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk NewbornsActive, not recruitingNCT07834008Not applicable1 country
- Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm BabiesCompletedNCT077653291 country
- High-Flow Nasal Cannula Versus Nasal CPAP as Primary Support in Preterm Respiratory Distress SyndromeCompletedNCT07693530Not applicable1 country
- Sedation Management in Pediatric Patients With Acute Respiratory Failure (The RESTORE Study)CompletedNCT00814099Not applicable1 country
- Premedication for Less Invasive Surfactant Administration Study (PRELISA)CompletedNCT05065424Phase 41 country
- Non-Inferiority Test of Mixsafe® Compared to Neopuff® in Providing Respiratory Support to NeonatesCompletedNCT07422116Not applicable1 country
- Predictors for Nasal Intermittent Positive Pressure Ventilation Failure for Premature Infants With Respiratory Distress SyndromeCompletedNCT052604241 country
- Feasibility Study of Placement and Surfactant Administration Through a Preterm Size Laryngeal Mask Airway in Very Low Birth Weight Neonates With Respiratory Distress SyndromeCompletedNCT06606444Not applicable1 country
- Airway Flow of RAM Cannula With BCPAP in InfantsCompletedNCT066979121 country
- Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled TrialCompletedNCT07009366Not applicable1 country
- Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants (LUNG Study)TerminatedNCT05198375Not applicable2 countries
- Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up TreatmentWithdrawnNCT05638568Not applicable1 country
- Feasibility and Impact of Volume Targeted Ventilation in the Delivery RoomTerminatedNCT03938532Not applicable1 country
- Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in NewbornsCompletedNCT066533741 country
- Epidemiology of Surfactant Protein-B DeficiencyCompletedNCT000148591 country
- Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA TrialCompletedNCT04500353Not applicable1 country
- Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress SyndromeTerminatedNCT02164734Phase 41 country
- Evaluating Pressures During Non-invasive Ventilation Utilizing NIV Plus SoftwareStatus unknownNCT05961683Not applicable1 country
- A Safety and Efficacy Study of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks Gestational AgeTerminatedNCT04264156Phase 21 country
- Early Neonatal Respiratory Distress: Changes in Level IIb Hospital Over a Period of One YearCompletedNCT028244971 country
- NIPPV vs.nCPAP During LISA ProcedureCompletedNCT05796128Not applicable1 country
- Breathing Variability and NAVA in NeonatesCompletedNCT040005681 country