Rectal Neoplasms: all 1,804 studies
Page 1 of 19. Open to participants first (520), then studies with results posted, then the rest; newest registration first within each.
- SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal CancerRecruitingNCT07888309Phase 2
- Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)Not yet recruitingNCT07871227
- Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer SurgeryNot yet recruitingNCT07862673Not applicable
- A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by Chemotherapy Plus PD-1 Inhibitor Versus Chemotherapy Alone in Locally Advanced Rectal CancerNot yet recruitingNCT07847229Phase 2
- Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal CancerNot yet recruitingNCT07846046Not applicable
- Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal CancerRecruitingNCT07833319Phase 2
- mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal CancerNot yet recruitingNCT07817888Phase 2
- Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal CancerNot yet recruitingNCT07811128
- Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal CancerNot yet recruitingNCT07810114Phase 2
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerRecruitingNCT07805369Phase 1
- Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal CancerRecruitingNCT07802197Not applicable
- Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast ImagingNot yet recruitingNCT07799740Not applicable
- HDR Endorectal Brachytherapy With 3D-Printed Guidance and Local Shielding for Rectal Cancer Organ PreservationRecruitingNCT07786493Not applicable
- Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing OutreachNot yet recruitingNCT07781774Not applicable
- ABCSG R07 Rectal Cancer RegistryNot yet recruitingNCT07780305
- 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal CancerNot yet recruitingNCT07779694Phase 2
- Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical TrialNot yet recruitingNCT07774754Phase 2
- NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARCNot yet recruitingNCT07765667Phase 2
- Quality of Life of Patients After Rectal Cancer Resection .Not yet recruitingNCT07764120
- Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal CancerNot yet recruitingNCT07761169Not applicable
- Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Rectal Cancer: A Randomized Controlled TrialNot yet recruitingNCT07755124Phase 1/2
- A Study of the Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally Advanced Rectal CancerNot yet recruitingNCT07740720Phase 3
- RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal CancerRecruitingNCT07735624Phase 2
- Aerobic Exercise and Guided Imagery in Low Anterior Resection SyndromeRecruitingNCT07732894Not applicable
- Hyperpolarized 13C-MRI and Radiomics in Rectal CancerRecruitingNCT07730541
- Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled TrialNot yet recruitingNCT07726966Not applicable
- COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine GreenNot yet recruitingNCT07720505
- Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer SurgeryNot yet recruitingNCT07696689Not applicable
- SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 CancerNot yet recruitingNCT07695519
- A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal CancerNot yet recruitingNCT07691489Phase 2
- Quicksilver II Pilot StudyNot yet recruitingNCT07688135Not applicable
- Oncolytic Virotherapy to Enhance PReoperative IMmunotherapy Efficacy in Patients With Proficient Mismatch Repair (pMMR) Rectal CancerRecruitingNCT07687875Phase 1
- Active Surveillance vs Adjuvant Chemoradiotherapy for Locally Resected Intermediate-Risk T1 Rectal CancerRecruitingNCT07669298Not applicable
- A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial)RecruitingNCT07669220Phase 2
- Transanal Total Mesorectal Excision vs Robotic Total Mesorectal ExcisionRecruitingNCT07651553Not applicable
- Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARCRecruitingNCT07646639Phase 2
- Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal NeoplasiaRecruitingNCT07632196Not applicable
- A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS MutationsRecruitingNCT07629960Phase 1/2
- Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical TrialRecruitingNCT07622771Phase 2
- KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal CancerNot yet recruitingNCT07622017Phase 2
- Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer PatientsRecruitingNCT07616297Not applicable
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced Solid Tumors Harboring KRAS G12D MutationsRecruitingNCT07610798Phase 1/2
- Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior ResectionRecruitingNCT07605611Not applicable
- Statewide Unified Network for Remote Intervention of Strength and ExerciseNot yet recruitingNCT07596732Not applicable
- Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3RecruitingNCT07595874Phase 2
- Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal CancerRecruitingNCT07595107
- Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical TrialRecruitingNCT07594925Phase 2
- Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal CancerNot yet recruitingNCT07580339Phase 2
- Rectal Cancer Neoadjuvant Therapy-Real World StudyRecruitingNCT07566559
- Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed by Local Excision at Stage I Rectal CancerNot yet recruitingNCT07563907Not applicable
- Low Rectal Cancer Treated With Total Neoadjuvant Therapy Plus Concurrent Tislelizumab ImmunotherapyRecruitingNCT07561060Phase 1/2
- Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal CancerNot yet recruitingNCT07552207Not applicable
- SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RCRecruitingNCT07549399Phase 3
- Improvement Effect of Dexamethasone Enema for Acute Radiation-induced Rectal InjuryNot yet recruitingNCT07548736Phase 2
- A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal CancerNot yet recruitingNCT07543848Phase 2
- Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.RecruitingNCT07537998Phase 2/3
- Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma.Not yet recruitingNCT07536321
- Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal CancerRecruitingNCT07528209Phase 3
- Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II TrialNot yet recruitingNCT07527520Phase 2
- Adaptive Radiotherapy for Safe HypofractionationNot yet recruitingNCT07516210Phase 2
- Intraoperative Rectal Lavage to Prevent Local Recurrence After Laparoscopic Mid-to-Low Rectal Cancer Resection: A Multicenter Randomized TrialRecruitingNCT07512232Not applicable
- Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal CanceNot yet recruitingNCT07509424Phase 2
- Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Without Concurrent Surufatinib in Neoadjuvant Therapy for Mid-to-low Localized Rectal Cancer of High-risk CriteriaRecruitingNCT07505472Phase 2/3
- Registry Maastro ApplicatorRecruitingNCT07501845
- Clinical and BIOgical Analyses of RECtal TumorsNot yet recruitingNCT07499921Not applicable
- MIMICC Study in Patients With Colorectal CancerRecruitingNCT07494201Not applicable
- The Application of a Novel Endoluminal Robotic System for Colorectal Endoscopic Submucosal DissectionNot yet recruitingNCT07486180Not applicable
- Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal CancerNot yet recruitingNCT07483060Phase 4
- SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARCRecruitingNCT07474103Not applicable
- FOLFIRINOX Induction Chemotherapy for Synchronous Liver MetastasesRecruitingNCT07467434
- REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency DepartmentRecruitingNCT07463261Not applicable
- Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal CancerRecruitingNCT07458529Phase 2
- A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) MutationRecruitingNCT07458347Phase 1
- Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)RecruitingNCT07433673Phase 2
- Quality Of Life In Colorectal Cancer SurvivorsRecruitingNCT07427901Not applicable
- Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic RadiotherapyRecruitingNCT07419490Not applicable
- Advanced Endoscopic Resections for Rectal NeoplasmsNot yet recruitingNCT07410767
- Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal CancerRecruitingNCT07407647Phase 2
- Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.RecruitingNCT07407465Phase 2
- Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent TreatmentRecruitingNCT07405476Phase 2
- Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant TreatmentNot yet recruitingNCT07404228
- A Phase II Prospective Study of Maastro Applicator Brachytherapy for Rectal CancerNot yet recruitingNCT07402486Phase 2
- Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal CancerNot yet recruitingNCT07397442Phase 2
- Postoperative Results and Outcomes in Surgical Pelvic ExenterationEnrolling by invitationNCT07395505
- Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal CancerNot yet recruitingNCT07394192Phase 2
- Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal CancerRecruitingNCT07393048
- Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study)Not yet recruitingNCT07381400Phase 2
- A Study on the Accurate Evaluation of Pseudoprogression of Rectal Cancer Immunotherapy Based on Multitemporal and Multiparameter MRIRecruitingNCT07381322
- The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal CancerEnrolling by invitationNCT07376980Not applicable
- Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal CancerRecruitingNCT07372300Phase 3
- The Impact of Probiotic Intervention on the Gut Microbiota and Bowel FunctionRecruitingNCT07369830Not applicable
- The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving SurgeryRecruitingNCT07369531Not applicable
- Autologous Probiotics in Patients With Defunctioning Ileostomy Following LAR for Rectal CancerNot yet recruitingNCT07366047Not applicable
- Pattern of Treatment and Outcomes of Locally Advanced Rectal CarcinomaNot yet recruitingNCT07363863
- Leucine Plus Radiochemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal CancerRecruitingNCT07359989Not applicable
- Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen ExtractionNot yet recruitingNCT07358247
- Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal ResectionsRecruitingNCT07351071Not applicable
- A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal CancerRecruitingNCT07347951Phase 2
- Tamsulosin for Early Catheter Removal After Rectal Cancer SurgeryRecruitingNCT07346586Not applicable
- Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative StudyEnrolling by invitationNCT07346534Not applicable