Rectal Neoplasms: all 1,804 studies

Page 3 of 19. Open to participants first (520), then studies with results posted, then the rest; newest registration first within each.

• Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical TrialRecruitingNCT06802172Not applicable
• Transanal Irrigation for Low Anterior Resection SyndromeNot yet recruitingNCT06796296Not applicable
• Intestinal Microbiome Modulation With Antibiotics in the Neoadjuvant Treatment of Locally Advanced Rectal CancerRecruitingNCT06793137Phase 2
• FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before SurgeryRecruitingNCT06780787Phase 2
• Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)RecruitingNCT06770270Phase 2
• The Use of Acupuncture to Reduce Chemotherapy Induced Peripheral Neuropathy in Gynaecological Cancer PatientsRecruitingNCT06769061Not applicable
• Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal CancerRecruitingNCT06765616Phase 2
• Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal CancerNot yet recruitingNCT06760520Phase 2
• Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.RecruitingNCT06758830Phase 2/3
• Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal CancerNot yet recruitingNCT06751394Phase 2
• A Prospective Study of Expression Profiling-based Assessment of the Efficacy of Neoadjuvant Therapy for Rectal CancerNot yet recruitingNCT06746298
• Designing a Dyad-Based mHealth Intervention to Improve Adherence to Lifestyle Recommendations in Colorectal Cancer Survivors and Their Family CaregiversRecruitingNCT06746012Not applicable
• Implementation of a Tumor Response Assessment Program Integrating the Shared Medical Decision Into the Organ Preservation Strategy for Rectal Cancer PatientsRecruitingNCT06740357Not applicable
• External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal CancerNot yet recruitingNCT06729645Not applicable
• Application of Amide Proton Transfer-Weighted Imaging in Predicting Pathological Complete Response After Neoadjuvant Therapy of Rectal CancerRecruitingNCT06719414
• Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal CancerRecruitingNCT06718543Phase 2
• Target-specific immunoPET Imaging of Digestive System CarcinomaRecruitingNCT06715839Not applicable
• Safety & Efficacy of a Novel Asymmetrical Linear Stapler (NALS) for Securing Distal Resection Margin in Laparoscopic Rectal Cancer Surgery: Pilot StudyNot yet recruitingNCT06709170Not applicable
• To Evaluate Dose and Safety of NanoEcho Particle-1 Using NanoEcho Imaging Device Examinations of Rectal Lymph Nodes in Healthy Volunteers and Rectal Cancer Patients.RecruitingNCT06693375Phase 2
• A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 ExpressionRecruitingNCT06682793Phase 1/2
• Brodalumab in the Treatment of Immune-Related Adverse EventsRecruitingNCT06673329Phase 1
• CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRCNot yet recruitingNCT06665087Phase 2
• Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal CancerRecruitingNCT06653452Not applicable
• CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRCNot yet recruitingNCT06652412Phase 2
• Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer（CONTROL-01）RecruitingNCT06647680Phase 2
• EMVI as a Determinant of Metastasis in Colorectal CancerRecruitingNCT06646341
• PET-imaging of Two Vartumabs in Patients With Solid TumorsRecruitingNCT06645808Early Phase 1
• A Study of Response to Standard Treatment Before Surgery in People With Rectal CancerRecruitingNCT06637462Not applicable
• Virtual Ileostomy Versus Diverting Ileostomy in Patients Undergoing Total Mesorectal ExcisionRecruitingNCT06633133Not applicable
• Asian Watch-and-Wait Database (AWWD)RecruitingNCT06631443
• Evaluating the Impact of Financial Navigation on Financial Catastrophe and Distress for Cancer CareRecruitingNCT06630962Not applicable
• Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.RecruitingNCT06628674Not applicable
• Preoperative (Chemo)Radiotherapy for Locally Recurrent Rectal CancerNot yet recruitingNCT06617052
• Study of the Predictive and Prognostic Role of Pharmacogenetic and Radiogenic Variants on the Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal CancerNot yet recruitingNCT06616870
• Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.Not yet recruitingNCT06613399Not applicable
• The Role and Safety of Radiofrequency Ablation in Recurrent Liver Metastasis of Colorectal CancerNot yet recruitingNCT06609434Not applicable
• Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant DiseaseRecruitingNCT06607458Phase 2
• Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARCNot yet recruitingNCT06599827Phase 2
• ctDNA Monitoring to Predict the Efficacy of TNT for Rectal CancerRecruitingNCT06589388
• Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant TherapyRecruitingNCT06569368Phase 2
• Conformal Sphincter-Preservation Operation Versus InterSphincteric Resection on Anal Function in Low Rectal CancerNot yet recruitingNCT06567756Not applicable
• Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk FactorsNot yet recruitingNCT06566222
• The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL TrialRecruitingNCT06565052Not applicable
• End to End Anastomosis With Omega Suture Versus End to Anterior Rectal Wall In Colorectal Anastomosis in Sigmoid and Upper Rectal CancerRecruitingNCT06546176Not applicable
• Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARCRecruitingNCT06542588Phase 2
• The Effect of Minimally Invasive Surgery on Systemic Inflammatory Response in Rectal CancerEnrolling by invitationNCT06540027
• Effects of Exosome Adminstration in Preventing Early Leakage in Rectal Cancer Patients Undergoing Low Anterior ResectionNot yet recruitingNCT06536712Phase 1
• Prospective Monocentric Study Evaluating the Circulating NK Cells Phenotype and the ImmunoScore® in Patients With Non Metastatic Rectal CancerRecruitingNCT06536127Not applicable
• Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum CancerRecruitingNCT06530303Phase 1/2
• Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled TrialNot yet recruitingNCT06524362Not applicable
• Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)RecruitingNCT06519006Not applicable
• Application of PD-1 Monoclonal Antibody in Combination With IL-2 and CapeOX in Organ Preservation Therapy for Ultra-Low Localized Advanced Rectal CancerNot yet recruitingNCT06504875
• Contact Radiotherapy for Rectal CancerRecruitingNCT06501053Not applicable
• Assessment of DW-MRI Measures : Reproducibility and Repeatability in Pelvic Imaging on MR-Linac With Healthy VolunteersNot yet recruitingNCT06458725Not applicable
• Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)RecruitingNCT06455124Phase 2
• Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)Not yet recruitingNCT06450574Phase 3
• Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal CancerNot yet recruitingNCT06443671Phase 2/3
• A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer PatientsRecruitingNCT06424522Not applicable
• Multimodal Imaging in Rectal Cancer & Pancreatic CancerNot yet recruitingNCT06395337Phase 1/2
• Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 StudyNot yet recruitingNCT06390982Phase 2
• Flexible Colonoscope Assisted Hybrid Transanal Total Mesorectal Resection (taTME)RecruitingNCT06380855
• Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)RecruitingNCT06380101Not applicable
• Correlation Between Gut Microbiota and Radiosensitivity of Rectal CancerNot yet recruitingNCT06375434
• Stigma and Psychological profilE in REctal-anal caNcer pAtientsRecruitingNCT06366841
• Peritoneum and Anterior Rectus Sheath Suturing and IleostomyRecruitingNCT06344923Not applicable
• Early Onset Colorectal Cancer DetectionRecruitingNCT06342401
• Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)RecruitingNCT06340646Not applicable
• Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal CancerRecruitingNCT06328361Not applicable
• Natural Orifice Specimen Extraction in Low Rectal Cancer SurgeryRecruitingNCT06326892
• PET/MR Evaluation of Regression Grading After Neoadjuvant Therapy for Rectal CancerRecruitingNCT06318234
• Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer PatientsRecruitingNCT06314646
• End to End Versus Side to End Anastomosis After Anterior Resection of Cancer RectumRecruitingNCT06311279Not applicable
• Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal CancerNot yet recruitingNCT06304987Phase 2
• Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular EndoscopyNot yet recruitingNCT06304597Phase 1
• Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With CamrelizumabNot yet recruitingNCT06304545Phase 2
• Genotype-driven Weekly Irinotecan Liposomes in Combination With Capecitabine-based Neoadjuvant Chemoradiation for Locally Advanced Rectal CancerRecruitingNCT06300489Phase 1
• Exercise for Improving Long-course Chemoradiotherapy Efficacy in People with Locally Advanced Rectal CancerRecruitingNCT06276686Early Phase 1
• Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diaryRecruitingNCT06274190Not applicable
• The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal AdenocarcinomaRecruitingNCT06266832Phase 2
• EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.RecruitingNCT06263088Not applicable
• The Effects of Neoadjuvant Tislelizumab Combined With Chemotherapy in Locally Advanced MSS Rectal CancerRecruitingNCT06254521Phase 2
• Study for Wait and Watch Suitable in Rectal CancerRecruitingNCT06252142
• Longterm Functional Outcomes in Patients Undergoing Organ Preserving Treatment for Rectal Cancer With or Without Local Excision After ChemoradiotherapyRecruitingNCT06249672
• Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal CancerRecruitingNCT06239870Phase 2
• Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid TumorsRecruitingNCT06239194Phase 1/2
• Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle RectumRecruitingNCT06236633Not applicable
• Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label StudyRecruitingNCT06234007Phase 2
• Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)RecruitingNCT06229041Phase 3
• No Stoma VS Ghost Stoma in Patients Undergoing Total Mesorectal Excision for Rectal CancerNot yet recruitingNCT06225609Not applicable
• The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)RecruitingNCT06222255Not applicable
• Quality of Life and Psychosocial Status of Young-onset Patients With Rectal CancerRecruitingNCT06216834
• Selective Defunctioning Stoma in Low Anterior Resection for Rectal CancerRecruitingNCT06214988Not applicable
• Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal CancerRecruitingNCT06209099Not applicable
• Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal CancerRecruitingNCT06205485Phase 3
• Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal CancerRecruitingNCT06204094Phase 2
• Reasons for Non-reversal of Temporary Stomas After Surgeries of Mid-low Rectal Cancer （NORESTO Study）RecruitingNCT06194708
• Total Neoadjuvant Therapy in Rectal CancerRecruitingNCT06162650Phase 2
• Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)RecruitingNCT06146946Not applicable
• Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid TumorsRecruitingNCT06128551Phase 1/2
• Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal CancerRecruitingNCT06123156Phase 3

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