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Post-Concussion Syndrome clinical trials

The registry lists 141 studies for Post-Concussion Syndrome across more than 10 countries. 34 are recruiting or about to start. 115 of them are mainly about Post-Concussion Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.

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Status

Completed
62
Recruiting
24
Status unknown
17
Terminated
13
Not yet recruiting
9
Active, not recruiting
8

Phase

Phase 2
20
Phase 1
8
Phase 3
3
Early Phase 1
3
Phase 4
2

Where

United States
77
Canada
30
Norway
6
Denmark
5
Israel
4
Belgium
2

Who runs them

University of Calgary (5) · Summit Hyperbarics and Wellness (4) · St. Olavs Hospital (4) · University of Aarhus (3) · University Health Network, Toronto (3) · Uniformed Services University of the Health Sciences (3) · VA Eastern Colorado Health Care System (3) · Boston Children's Hospital (3)

What is being tested here

Drugs under test in Post-Concussion Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Metoclopramide102
Acetaminophen101
Quetiapine111
Hyperbaric Oxygen013
Sildenafil003
Prazosin001
Magnesium Oxide001
Erenumab001
Ondansetron001
Nortriptyline001

Drug classes tested here Antiemetics 1 open

Coming up

1phase 3 study under way
13studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 24 Post-Concussion Syndrome studies recruiting now, 3 (13%) set no upper age limit and 20 (83%) stop at 75 or younger. 2 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (21%) take healthy volunteers.

Recruiting studies that take each age, of 24
AgeWomenMen
101 (4%)1 (4%)
1822 (92%)22 (92%)
3022 (92%)22 (92%)
4022 (92%)22 (92%)
5022 (92%)22 (92%)
6516 (67%)16 (67%)
757 (29%)7 (29%)
854 (17%)4 (17%)

Across all 141 studies, recruiting or not: 79% stop at 75 or younger and 72% at 65; 29% take children; 1% are for women only and 1% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Post-Concussion Syndrome studies take

Of 56 interventional studies with no phase under Post-Concussion Syndrome, half reached primary completion within 40 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase40 mo23–69 · 56 studies—40 mo24–58 · 54 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Results posted1

Newly registered3

Studies

Recruiting first, then most recently updated. Showing 50 of 141. Browse all 141 → or search them.