An observational study in Long COVID, sponsored by Hopitaux de Saint-Maurice. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Hopitaux de Saint-Maurice · Observational
This retrospective, single-center observational study investigates the relationship between cognitive performance and return to work in patients with Long COVID. The study includes patients followed in the Long COVID day hospital at Hôpitaux Paris Est Val-de-Marne who underwent a neuropsychological assessment as part of routine care. Cognitive performance in executive functions, attention, memory, and processing speed is analyzed in relation to employment status at the time of assessment and six months later.
Long COVID is characterized by persistent symptoms following acute SARS-CoV-2 infection and may include cognitive difficulties affecting attention, memory, executive functions, and processing speed. These impairments may interfere with daily functioning and the ability to maintain or resume professional activity.
This retrospective single-center study is based on the reuse of routinely collected healthcare data from patients followed in the Long COVID day hospital of Hôpitaux Paris Est Val-de-Marne. No additional examinations, questionnaires, or data collection are performed specifically for the research.
The primary objective is to investigate the association between cognitive performance assessed during neuropsychological evaluation and return to professional activity six months later. Secondary objectives are to describe the frequency and profile of cognitive impairments across different cognitive domains, describe return-to-work modalities at six months, compare cognitive performance according to employment status and type of return to work, and explore potential relationships between anxiety and depressive symptoms, cognitive performance, and occupational outcomes.
The analyzed data include sociodemographic and clinical characteristics, neuropsychological test scores assessing attention, executive functions, short- and long-term memory, and processing speed, as well as anxiety and depression questionnaire scores. Employment status is assessed at the time of neuropsychological evaluation and six months later, including no return to work, partial return, or full return.
536 studies on the registry are indexed under Post-Acute COVID-19 Syndrome; 187 are open to participants now.
This study's enrollment of 55 is below the median of 160 across 149 observational studies indexed under Post-Acute COVID-19 Syndrome.
Browse Post-Acute COVID-19 Syndrome studies →Hopitaux de Saint-Maurice is the lead sponsor of 16 studies on the registry; 6 are open to participants now.
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Adult patients with Long COVID followed in the Long COVID day hospital at Hôpitaux Paris Est Val-de-Marne who underwent a neuropsychological assessment as part of routine clinical care. The study retrospectively reuses existing clinical, neuropsychological, psychological, and occupational data. For analyses of return to work, patients were professionally active before COVID and had employment-status data available at 6-month follow-up.
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Exclusion Criteria:
Adult patients with Long COVID followed in the long COVID day hospital at Hôpitaux Paris Est Val-de-Marne who underwent a neuropsychological assessment as part of routine care and met the study eligibility criteria
Processing Speed According to Return-to-Work Status at 6 Months
Processing speed assessed using the Coding subtest of the WAIS-IV at the neuropsychological assessment, compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Verbal Short-Term Memory According to Return-to-Work Status at 6 Months
Verbal short-term memory assessed using the auditory-verbal span from the WAIS-IV, compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Visual Short-Term Memory According to Return-to-Work Status at 6 Months
Visual short-term memory assessed using the visuospatial span from the MEM-III, compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Long-Term Verbal Memory According to Return-to-Work Status at 6 Months
Long-term verbal memory was assessed using the RL/RI-16 test. Measures included retrieval (sum of the three free-recall trials), storage (sum of the three total-recall trials and recognition), and long-term consolidation (delayed free and total recall). Performance was compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Selective Attention According to Return-to-Work Status at 6 Months
Selective attention was assessed using the D2 or D2-R test, based on response accuracy and errors. Performance was compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Sustained Attention According to Return-to-Work Status at 6 Months
Sustained attention was assessed using the D2 or D2-R test, based on concentration performance. Performance was compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Mental Flexibility According to Return-to-Work Status at 6 Months
Mental flexibility was assessed using the Trail Making Test (TMT), including errors on Part B and the B-A completion-time difference. Performance was compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Inhibition According to Return-to-Work Status at 6 Months
Inhibitory control was assessed using the Stroop Test, including errors on the interference condition and the interference time adjusted for naming time. Performance was compared according to return-to-work status at 6 months.
Time frame: From the neuropsychological assessment to 6-month follow-up
Frequency of Below-Norm Cognitive Performance by Domain Using Standardized Neuropsychological Tests
Frequency of participants with cognitive performance below normative values in each assessed domain. Processing speed was assessed with the WAIS-IV Coding subtest; verbal short-term memory with the WAIS-IV auditory-verbal span; visual short-term memory with the MEM-III visuospatial span; long-term verbal memory with the RL/RI-16; selective and sustained attention with the D2/D2-R; and executive functions with the Trail Making Test and Stroop Test. Classification as below normative values was based on the normative interpretation applicable to each test.
Time frame: Baseline
Number of Participants According to Return-to-Work Status at 6 Months
Number of participants according to return-to-work status at 6-month follow-up: return to work or no return to work. Among participants who returned to work, partial and full return to work will also be described.
Time frame: 6 months after the neuropsychological assessment
Cognitive Performance According to Employment Status at Neuropsychological Assessment and at 6 Months
Cognitive performance was assessed using standardized neuropsychological tests covering processing speed (WAIS-IV Coding), verbal short-term memory (WAIS-IV auditory-verbal span), visual short-term memory (MEM-III visuospatial span), long-term verbal memory (RL/RI-16), attention (D2/D2-R), mental flexibility (Trail Making Test), and inhibition (Stroop Test). Performance was compared according to employment status at the neuropsychological assessment and at 6-month follow-up.
Time frame: From the neuropsychological assessment to 6-month follow-up
Anxiety Symptoms Assessed With the State-Trait Anxiety Inventory (STAI)
Anxiety symptoms were assessed using the State-Trait Anxiety Inventory (STAI), including state and trait anxiety measures.
Time frame: Baseline
Depressive Symptoms Assessed With the Beck Depression Inventory (BDI)
Depressive symptoms were assessed using the Beck Depression Inventory (BDI).
Time frame: Baseline
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Post-Acute COVID-19 Syndrome →
Hopitaux de Saint-Maurice