Drug
Fosbretabulin clinical trials
Also written Combretastatin A-4 Phosphate.
Includes 6 studies of Fosbretabulin tromethamine.
How studies write it
Studies that test it under each name
Studies by the year they started
19 studies that test it; most in 2003 (3)
| Year | Studies |
|---|---|
| 1998 | 2 |
| 2003 | 3 |
| 2005 | 2 |
| 2006 | 1 |
| 2007 | 1 |
| 2008 | 1 |
| 2009 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2014 | 3 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 10 · Other 9
Mateon Therapeutics (10) · Case Comprehensive Cancer Center (3) · National Cancer Institute (NCI) (1) · Johns Hopkins University (1) · University of Glasgow (1) · The Christie NHS Foundation Trust (1) · Lowell Anthony, MD (1) · West Virginia University (1)
Often tested with
Tested in the same studies.
Paclitaxel (2) · Carboplatin (2) · Bevacizumab (2) · Everolimus (1) · Cisplatin (1) · Doxorubicin (1)
Related medicines
As reviewed, each with the page that says it.
- One of Antimitotic Agents source
Studies
Open first, then newest update. How each study uses fosbretabulin is read from its arms, and is right about nine times in ten.
Testing it · 19
- FOCUS: PCC + Bevacizumab + CA4P Versus PCC + Bevacizumab + Placebo for Subjects With Platinum Resistant Ovarian CancerTerminatedPhase 2/3Mateon TherapeuticsNCT02641639Written as Fosbretabulin tromethamine
- PAZOFOS: Phase Ib and Phase II Trial of Pazopanib +/- Fosbretabulin in Advanced Recurrent Ovarian CancerTerminatedPhase 1/2The Christie NHS Foundation TrustNCT02055690Written as Fosbretabulin
- Fosbretabulin With Everolimus in Neuroendocrine Tumors With ProgressionTerminatedPhase 1Lowell Anthony, MDNCT03014297Written as fosbretabulin
- Bevacizumab With or Without Fosbretabulin Tromethamine in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity CancerCompletedPhase 2National Cancer Institute (NCI)NCT01305213Written as Fosbretabulin Tromethamine
- Rollover Protocol for Subjects Who Have Responded on Study 4218s - A Phase 2 StudyCompletedPhase 2Mateon TherapeuticsNCT02279602Written as fosbretabulin
- Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular DegenerationCompletedPhase 1/2Johns Hopkins UniversityNCT01570790Written as Combretastatin A-4 phosphate
- A Ph 2 Study of Fosbretabulin in Subjects w Pancreatic or Gastrointestinal Neuroendocrine Tumors w Elevated BiomarkersCompletedPhase 2Mateon TherapeuticsNCT02132468Written as fosbretabulin tromethamine
- OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade GliomasWithdrawnPhase 1West Virginia UniversityNCT01052363Written as Bevacizumab, CA4P
- A Safety and Efficacy Study of Carboplatin, Paclitaxel, Bevacizumab and CA4P in Non-Small Cell Lung CancerCompletedPhase 2Mateon TherapeuticsNCT00653939Written as Fosbretabulin
- Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid CancerTerminatedPhase 2/3Mateon TherapeuticsNCT00507429Written as CA4P
- Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid CancerWithdrawnPhase 3Mateon TherapeuticsNCT01701349Written as Fosbretabulin + paclitaxel + carboplatin
- Combretastatin A4 Phosphate in Treating Patients With Advanced Solid TumorsCompletedPhase 1Case Comprehensive Cancer CenterNCT00003768Written as fosbretabulin disodium
- Chemotherapy in Treating Patients With Solid TumorsCompletedPhase 1University of GlasgowNCT00003698Written as fosbretabulin disodium
- Safety and Effectiveness of Combretastatin A-4 Phosphate Combined With Chemotherapy in Advanced Solid TumorsCompletedPhase 2Mateon TherapeuticsNCT00113438Written as Combretastatin A-4 Phosphate + Paclitaxel + Carboplatin
- Safety and Efficacy Study of Combretastatin A4 Phosphate to Treat Patients With Choroidal Neovascularization Secondary to Pathologic MyopiaCompletedPhase 2Mateon TherapeuticsNCT01423149Written as Combretastatin A-4 Phosphate
- Study Evaluating the Safety and Response of Fosbretabulin in Asian Patients With Polypoidal Choroidal Vasculopathy (PCV)CompletedPhase 2Mateon TherapeuticsNCT01023295Written as fosbretabulin
- Safety Study of Increasing Doses of Combretastatin in Combination With Bevacizumab (Avastin) in Patients With Advanced Solid TumorsCompletedPhase 1Mateon TherapeuticsNCT00395434Written as Combretastatin A4 Phosphate (CA4P)
- Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid CancerCompletedPhase 2Case Comprehensive Cancer CenterNCT00060242Written as fosbretabulin disodium
- Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4 Phosphate and Radiation Therapy in Treating Patients With Newly Diagnosed Regionally Advanced Anaplastic Thyroid CancerTerminatedPhase 1/2Case Comprehensive Cancer CenterNCT00077103Written as fosbretabulin disodium
Codes
What other systems call fosbretabulin · ClinicalTrials.gg INT003422
- MeSH (NLM) C058728fosbretabulinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) I5590ES2QZFOSBRETABULINConfirmed FDA, NLM, Wikidata
- Wikidata Q5150956fosbretabulinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C82378FosbretabulinOne source FDA
- DrugBank DB12577One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C058728 | fosbretabulin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | I5590ES2QZ | FOSBRETABULIN | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q5150956 | fosbretabulin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C82378 | Fosbretabulin | One source FDA |
| DrugBank | DB12577 | — | One source Wikidata |
Also registered as combrestatin a4 (UNII 16U6OP69RQ) and fosbretabulin disodium (UNII 702RHR475O).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.