Pleural Effusion, Malignant clinical trials
The registry lists 169 studies for Pleural Effusion, Malignant across more than 10 countries. 39 are recruiting or about to start. 124 of them are mainly about Pleural Effusion, Malignant (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Pleural Effusion, Malignant studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
National Cancer Institute (NCI) (8) · Naestved Hospital (6) · Assiut University (6) · M.D. Anderson Cancer Center (5) · The University of Hong Kong (4) · Post Graduate Institute of Medical Education and Research, Chandigarh (3) · H. Lee Moffitt Cancer Center and Research Institute (3) · Jemincare (2)
What is being tested here
Drugs under test in Pleural Effusion, Malignant studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| JMKX000197 | 3 | 0 | 3 |
| Interleukin-2 | 2 | 0 | 2 |
| Aflutinib | 1 | 0 | 1 |
| Tocilizumab | 1 | 0 | 1 |
| MT027 | 1 | 0 | 1 |
| Bevacizumab | 0 | 1 | 6 |
| Carboplatin | 0 | 0 | 5 |
| Cisplatin | 0 | 0 | 4 |
| Paclitaxel | 0 | 0 | 3 |
| Docetaxel | 0 | 0 | 3 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · Angiogenesis inhibitors 7 · Antimitotic agents 5 · Antimetabolites 5 · Immune checkpoint inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Biomarker Levels During Indwelling Pleural cAtheter Sample Testing · Johns Hopkins University
- Dec 2026A Study to Establish the Diagnostic Value of the EPISEEK-MPE Liquid Biopsy Assay to Identify Cancer in Pleural Effusion Samples. · University of Arizona
- Jan 2027Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis · University of Health Sciences Lahore
- Jan 2027Pleurodesis in Small-bore Chest Tube · The University of Hong Kong
- Jul 2027Safety and Efficacy of NK510 to Treat NSCLC · Base Therapeutics (Shanghai) Co., Ltd.
- Aug 2027Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions · Sohag University
- Oct 2027Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion · Jiangmen Central Hospital
Who these studies take
Of the 25 Pleural Effusion, Malignant studies recruiting now, 15 (60%) set no upper age limit and 5 (20%) stop at 75 or younger. 3 (12%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (12%) | 3 (12%) |
| 18 | 25 (100%) | 25 (100%) |
| 30 | 25 (100%) | 25 (100%) |
| 40 | 25 (100%) | 25 (100%) |
| 50 | 25 (100%) | 25 (100%) |
| 65 | 25 (100%) | 25 (100%) |
| 75 | 25 (100%) | 25 (100%) |
| 85 | 18 (72%) | 18 (72%) |
Across all 169 studies, recruiting or not: 11% stop at 75 or younger and 1% at 65; 8% take children; 2% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pleural Effusion, Malignant studies take
Of 22 observational studies under Pleural Effusion, Malignant, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 27 mo12–44 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 169. Browse all 169 → or search them.
- A Study to Establish the Diagnostic Value of the EPISEEK-MPE Liquid Biopsy Assay to Identify Cancer in Pleural Effusion Samples.RecruitingNCT079295841 country
- Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung CanceNot yet recruitingNCT078827581 country
- UNC Pleural Fluid RegistryRecruitingNCT056203291 country
- Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural EffusionRecruitingNCT07726784Not applicable1 country
- Safety and Efficacy of NK510 to Treat NSCLCRecruitingNCT06097962Early Phase 11 country
- Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural EffusionsNot yet recruitingNCT07766876
- Fast TILs to Treat Metastatic Cancer Patients With Pleural DiseaseRecruitingNCT07192900Phase 11 country
- Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural EffusionNot yet recruitingNCT07482605Phase 2
- A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLCRecruitingNCT05543330Phase 1/21 country
- Xuan Yin Ning Plus Bevacizumab for Malignant Pleural EffusionNot yet recruitingNCT07670338Not applicable1 country
- Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.RecruitingNCT04806412Not applicable1 country
- Ex Vivo Drug Response Profiling and Outcome Prediction in Lung AdenocarcinomaRecruitingNCT076362521 country
- A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural EffusionNot yet recruitingNCT07649369Phase 21 country
- WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I)Not yet recruitingNCT07615894Phase 11 country
- First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural EffusionRecruitingNCT07332858Phase 1/21 country
- Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary TumorsRecruitingNCT07443020Phase 11 country
- Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in PleurodesisNot yet recruitingNCT07167992Not applicable1 country
- Pleurodesis in Small-bore Chest TubeNot yet recruitingNCT07208409Not applicable1 country
- Biomarker Levels During Indwelling Pleural cAtheter Sample TestingEnrolling by invitationNCT020921551 country
- Impact of Patient Position on Chemical Pleurodesis by Chest UltrasoundRecruitingNCT07147270Not applicable1 country
- Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic CancerRecruitingNCT06016179Phase 11 country
- Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural EffusionNot yet recruitingNCT06964321Not applicable
- ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNGRecruitingNCT06959719Not applicable1 country
- First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.RecruitingNCT06946498Not applicable1 country
- A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural EffusionRecruitingNCT06740019Phase 11 country
- The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural EffusionNot yet recruitingNCT06742099Early Phase 11 country
- A Study of MT027 in Patients with Pleural Malignant TumorsRecruitingNCT06726564Phase 11 country
- Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural EffusionNot yet recruitingNCT06691009Not applicable1 country
- Dual-targeting HER2 and PD-L1 CAR-T for Solid TumorsRecruitingNCT04684459Early Phase 11 country
- Clinical Study on Intraluminal Injection of FOLactisRecruitingNCT06512896Not applicable1 country
- OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.RecruitingNCT06421610Phase 11 country
- IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and AscitesRecruitingNCT05268172Phase 11 country
- Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective StudyNot yet recruitingNCT06275178
- A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From Malignant Pleural EffusionRecruitingNCT059356961 country
- A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural EffusionRecruitingNCT05923515Phase 11 country
- Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural InterventionRecruitingNCT059101121 country
- Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)RecruitingNCT05872126Not applicable1 country
- Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural EffusionNot yet recruitingNCT05693727
- Longitudinal Follow up of Patients With Pleural EffusionRecruitingNCT046705621 country
- Feasibility of Ambulatory Talc. PleurodesisCompletedNCT06682936Not applicable1 country
- Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical TrialCompletedNCT07120867Not applicable1 country
- Intrapleural Catheter Daily Versus Three Times a Week DrainageActive, not recruitingNCT00761618Phase 21 country
- Synchronous Bilateral Talc PleurodesisCompletedNCT078100491 country
- Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including MesotheliomaCompletedNCT05278975Phase 1/21 country
- Pleural Carcinomatosis Tissue BankingCompletedNCT048448271 country
- AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural EffusionCompletedNCT04322136Not applicable1 country
- Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)CompletedNCT054614301 country
- Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal CancerCompletedNCT02122185Phase 21 country
- PMCF Study of the CE-marked Drainova® ArgentiC CatheterCompletedNCT064368071 country
- A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural EffusionsActive, not recruitingNCT04914598Phase 31 country