Pleural Effusion clinical trials
The registry lists 241 studies for Pleural Effusion across more than 10 countries. 50 are recruiting or about to start. 132 of them are mainly about Pleural Effusion (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Pleural Effusion, Malignant too: 381 studies, 81 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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Who runs them
Assiut University (14) · China-Japan Friendship Hospital (6) · Post Graduate Institute of Medical Education and Research, Chandigarh (5) · National University of Malaysia (5) · University of Oxford (5) · Chinese University of Hong Kong (4) · Yale University (4) · Naestved Hospital (4)
What is being tested here
Drugs under test in Pleural Effusion studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Thrombolytics 6 · Tyrosine kinase inhibitors (TKIs) 3 · NSAIDs 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU · Brigham and Women's Hospital
- Nov 2026Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases · Assiut University
- Nov 2026Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +] · Beth Israel Deaconess Medical Center
- Dec 2026Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System · Johns Hopkins University
- Dec 2026A Study to Establish the Diagnostic Value of the EPISEEK-MPE Liquid Biopsy Assay to Identify Cancer in Pleural Effusion Samples. · University of Arizona
- Dec 2026Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients · Fu Jen Catholic University
- Jan 2027Organoid-guided Personalized Treatment of Pleural Effusion · Henan Cancer Hospital
- Mar 2027Prospective Evaluation of Patients With Pleural Effusion · Chinese University of Hong Kong
- Apr 202716F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy · University Hospital, Basel, Switzerland
- May 2027Study of the Benefits of Virtual Reality Headsets for Reducing Anxiety in Patients Treated for Pleural Effusion or Pneumothorax Using Small-bore Chest Drainage Tubes · Centre Hospitalier Universitaire de Nice
Who these studies take
Of the 31 Pleural Effusion studies recruiting now, 25 (81%) set no upper age limit and 2 (6%) stop at 75 or younger. 3 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (10%) | 3 (10%) |
| 18 | 28 (90%) | 28 (90%) |
| 30 | 29 (94%) | 29 (94%) |
| 40 | 29 (94%) | 29 (94%) |
| 50 | 29 (94%) | 29 (94%) |
| 65 | 29 (94%) | 29 (94%) |
| 75 | 29 (94%) | 29 (94%) |
| 85 | 27 (87%) | 27 (87%) |
Across all 241 studies, recruiting or not: 12% stop at 75 or younger and 8% at 65; 16% take children; 1% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pleural Effusion studies take
Of 63 interventional studies with no phase under Pleural Effusion, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 26 mo16–52 · 63 studies | — | 29 mo17–52 · 61 studies |
| Observational | 26 mo15–48 · 35 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 241. Browse all 241 → or search them.
- A Study to Establish the Diagnostic Value of the EPISEEK-MPE Liquid Biopsy Assay to Identify Cancer in Pleural Effusion Samples.RecruitingNCT079295841 country
- Pneumonia and Pleuropneumonia in Hospitalized ChildrenRecruitingNCT052746071 country
- Iodine Starch Test Use in Pleuroperitoneal LeakNot yet recruitingNCT07857564Not applicable
- Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or EmpyemaRecruitingNCT07095361Phase 41 country
- Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary DiseasesRecruitingNCT069833661 country
- Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural InfectionNot yet recruitingNCT078230751 country
- Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna TrialRecruitingNCT06686251Not applicable1 country
- Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural EffusionRecruitingNCT07726784Not applicable1 country
- Prospective Evaluation of Patients With Pleural EffusionRecruitingNCT057591171 country
- Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]RecruitingNCT06713382Phase 21 country
- Pleural Irrigation With a Novel Devise.RecruitingNCT06727578Not applicable1 country
- Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource SettingsNot yet recruitingNCT07667608
- Dual-function Semirigid Thoracoscopy Versus Rigid Thoracoscopy for the Diagnosis of Pleural DiseaseNot yet recruitingNCT07114783Not applicable
- Evaluating the Use of an App in Pleural Disease: Algorithm-supported Clinical Decision Making Versus Usual CareEnrolling by invitationNCT07625176Not applicable1 country
- Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural EffusionRecruitingNCT059450431 country
- 16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or SegmentectomyRecruitingNCT06958848Not applicable1 country
- DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNsRecruitingNCT07419360Not applicable1 country
- Pleural Effusion Types in Chronic Kidney DiseaseNot yet recruitingNCT07547852
- Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural DiseaseRecruitingNCT06741839Not applicable1 country
- Evaluation of Transthoracic Ultrasonography in Differentiating Pleural EffusionsNot yet recruitingNCT07513909
- Pleural Effusion Biomarkers in Lung Adenocarcinoma PatientsRecruitingNCT070127591 country
- Ultrasounic Elastography-guided Pleural Biopsy Followed by As-needed Medical Thoracoscopic Pleural Biopsy Versus Immediate Medical Thoracoscopic Pleural Biopsy for the Diagnosis of Pleural EffusionNot yet recruitingNCT07419620Not applicable1 country
- Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural EffusionRecruitingNCT07248774Not applicable1 country
- Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICURecruitingNCT06538376Not applicable1 country
- Outcomes of a Single Chest Drain vs Two DrainsRecruitingNCT07125248Not applicable1 country
- Diagnostic Utility of Pleural Infection-specific Multiplex PCR PanelNot yet recruitingNCT070770961 country
- Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural BiopsyNot yet recruitingNCT07040241Not applicable
- ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNGRecruitingNCT06959719Not applicable1 country
- Organoid-guided Personalized Treatment of Pleural EffusionRecruitingNCT069591731 country
- First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.RecruitingNCT06946498Not applicable1 country
- Drainage Of Pleural Effusions in the Intensive Care Unit (DOPE-ICU) - Feasibility TrialRecruitingNCT06709456Not applicable1 country
- Indwelling Pleural Catheters: a Self-management InterventionEnrolling by invitationNCT069108001 country
- Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use of an Augmented Reality SimulatorRecruitingNCT059607471 country
- Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural EffusionRecruitingNCT06734481Not applicable1 country
- Strategy for Prompt and Effective Thoracentesis in the Emergency DepartmentRecruitingNCT06180603Not applicable1 country
- Chest Drain Insertion Assisted by Virtual RealityNot yet recruitingNCT06589739Not applicable
- OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.RecruitingNCT06421610Phase 11 country
- The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural EffusionRecruitingNCT05781659Not applicable1 country
- Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective StudyNot yet recruitingNCT06275178
- Validity of Pleural Effusion Detection SoftwareEnrolling by invitationNCT059032871 country
- Clinical Validation of Programmable Drain Fluid Regulator to Reduce Morbidity, Care Requirements, and Improve OutcomesRecruitingNCT05734729Not applicable1 country
- Ultrasound-guided Pigtail Catheter Versus Intercostal Tube Drainage of Non-traumatic Exudative Pleural EffusionNot yet recruitingNCT06099054Not applicable
- The INSIGHT Feasibility Study Ultrasound in the Intensive Care Unit: A Randomised Controlled Feasibility TrialNot yet recruitingNCT05569798Not applicable1 country
- Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel DataRecruitingNCT04418804Not applicable1 country
- Efficacy of Topical Lidocaine/Prilocaine in Pain Management in PleurocentesisRecruitingNCT05984264Phase 41 country
- A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From Malignant Pleural EffusionRecruitingNCT059356961 country
- Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural InterventionRecruitingNCT059101121 country
- Pigtail Catheter for Drainage of (Pneumothorax/Simple Effusion) is a Effective ProcedureNot yet recruitingNCT056417791 country
- Role of Ultrasound Elastography in Pleural EffusionNot yet recruitingNCT05642091Not applicable
- Collection of Pleural Effusion FluidNot yet recruitingNCT05539183Not applicable