Persistent Fetal Circulation Syndrome clinical trials

The registry lists 40 studies for Persistent Fetal Circulation Syndrome across more than 10 countries. 6 are recruiting or about to start. 32 of them are mainly about Persistent Fetal Circulation Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22.

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Status

Completed: 15
Terminated: 8
Status unknown: 6
Recruiting: 5
Withdrawn: 4
Not yet recruiting: 1

Phase

Phase 2: 8
Phase 3: 5
Phase 1: 4
Phase 4: 4

Where

United States: 16
Egypt: 4
United Kingdom: 3
China: 3
France: 3
Canada: 2

Who runs them

NICHD Neonatal Research Network (5) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Sohag University (2) · University of Florida (1) · Children's Hospital of Philadelphia (1) · University of North Carolina, Chapel Hill (1) · Children's Hospital of Fudan University (1)

What is being tested here

Drugs under test in Persistent Fetal Circulation Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Melatonin	1	0	1
Magnesium Sulfate	1	0	1
Sildenafil	0	2	6
Nitric Oxide	0	2	4
Milrinone	0	0	2
Iloprost	0	0	2
Magnesium	0	0	1
Bosentan	0	1	1
Treprostinil	0	0	1
Alprostadil	0	0	1

Coming up

0phase 3 studies under way

3studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 3

Nov 2026Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates · Ain Shams University
Dec 2026Close Loop Smart Weaning for INO With PPHN · Children's Hospital of Fudan University
Jul 2027Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness · Ferrer Internacional S.A.

Who these studies take

Of the 5 Persistent Fetal Circulation Syndrome studies recruiting now, 2 (40%) set no upper age limit and 3 (60%) stop at 75 or younger. 5 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (20%) take healthy volunteers.

Recruiting studies that take each age, of 5
Age	Women	Men
10	2 (40%)	2 (40%)
18	2 (40%)	2 (40%)
30	2 (40%)	2 (40%)
40	2 (40%)	2 (40%)
50	2 (40%)	2 (40%)
65	2 (40%)	2 (40%)
75	2 (40%)	2 (40%)
85	2 (40%)	2 (40%)

Across all 40 studies, recruiting or not: 88% stop at 75 or younger and 88% at 65; 95% take children; 8% are for women only and 3% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 40 of 40. search them.