An interventional study of Prehospital ECMO cannulation on scene of cardiac arrest and Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation in Cardiac Arrest (CA) and Cardiogenic Shock, sponsored by University Hospital Ostrava. Recruiting at 2 sites in Czechia. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-01-30.
Sponsored by University Hospital Ostrava · Not applicable, Interventional, and Treatment
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.
ECPR is a life-saving method for a selected group of patients who are refractory to standard resuscitation procedures. With the appropriate use of ECPR, it is possible to achieve a significant improvement in survival with good neurological outcomes even in patients who would otherwise die. The ECMO Centre Ostrava has been providing ECPR for OHCA since 2022 with cannulation in the hospital after prior transport from the scene under continuous resuscitation. A good neurological outcome is achieved in approximately 29% of patients, even though the collapse-ECMO interval is around 75 minutes. Shortening this interval, which is associated with improved outcomes, is possible by using a mobile team that per-forms cannulation directly on scene. Mobile ECPR will be carried out in cooperation with the Ostrava University Hospital and the Moravian-Silesian Region Emergency Medical Service. The primary objective is to verify the benefit of on-scene ECPR in terms of shortening the collapse-ECMO interval. The secondary objective is to compare the outcome in the on-scene ECPR group with hospital cannulation.
926 studies on the registry are indexed under Heart Arrest; 226 are open to participants now.
This study's planned enrollment of 90 is close to the median of 100 across 518 interventional studies indexed under Heart Arrest.
Browse Heart Arrest studies →University Hospital Ostrava is the lead sponsor of 148 studies on the registry; 50 are open to participants now.
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Exclusion Criteria:
On-scene ECPR cannulation by mobile ECMO team according to protocol if the location of the arrest and circumstances appear to be suitable (distance from the ECMO centre, transport logistics, in an ambulance/at home, etc.)
Procedure: Prehospital ECMO cannulation on scene of cardiac arrest
Hospital ECPR cannulation at Emergency Department by ECMO team accord-ing to protocol if a on scene ECPR call-out was not indicated.
Procedure: Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.
ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.
Hospital survival
Hospital survival will be assessed 30 days after the cardiac arrest
Time frame: 30 days after the cardiac arrest
ICU stay
The length of the Intensive Care Unit (ICU) stay will be assessed in days.
Time frame: Through the ICU stay, on average 12 days
Neurologic outcomes
Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).
Time frame: 30 days after the cardiac arrest
Collapse to ECMO interval
The interval from the collapse (cardiac arrest) to ECMO initiation will be measured in minutes.
Time frame: One hour
Collapse to ECMO interval
The interval from the collapse (cardiac arrest) to ECMO initiation will be measured in minutes.
Time frame: From the collapse (cardiac arrest) to ECMO initiation
Long-term outcome - Survival
The long-term survival of patients will be assessed 6 months after the collapse.
Time frame: 6 months after the collapse
Long-term outcome - Quality of Life
Long-term quality of life will be assessed 6 months after the collapse using standardised tools (questionnaires).
Time frame: 6 months after the collapse
Plan to share: No — There is no plan to make individual participant data available to other researchers. The data may be provided upon reasonable request.
No publications or documents are linked to this record.
Start is estimated for Jan 2026; primary completion for Dec 2028, 35 months later.
Of 204 non-industry interventional studies with no phase under Heart Arrest, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 47. This study's planned 35 months is above that.
Counting every sponsor, half of 218 studies reached it within 28 months; a quarter within 10 and three quarters within 47.
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