Optic Nerve Diseases clinical trials
The registry lists 61 studies for Optic Nerve Diseases across more than 10 countries. 22 are recruiting or about to start. 22 of them are mainly about Optic Nerve Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 7 narrower conditions too, such as Neuromyelitis Optica: 480 studies, 135 open.
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Who runs them
Duke University (3) · Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (2) · MD Stem Cells (2) · Stanford University (2) · Fondation Ophtalmologique Adolphe de Rothschild (2) · Bayer (2) · University of Magdeburg (2) · Clene Nanomedicine (2)
What is being tested here
Drugs under test in Optic Nerve Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Sep 2027Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) · Phase 3 · Dompé Farmaceutici S.p.A
- Nov 2026NAION in Non-Diabetic Obese Patients Using GLP-1 Receptor Agonists: A Real-World Study · Istanbul Saglik Bilimleri University
- Dec 2026Electrical Stimulation for the Treatment of Optic Neuropathies · Stanford University
- Mar 2027Advancing Pediatric Retinal Imaging With Auto-aligned OCT · Duke University
- Mar 2027STReetlab Assessment Tool of Activities Daily Living in Glaucoma Patient · Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
- May 2027Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions) · Life Biosciences Inc.
- Jun 2027A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With Blindness · Illinois Institute of Technology
- Jul 2027Optimize Pediatric OCT Imaging · Duke University
- Jul 2027Stem Cell Ophthalmology Treatment Study II · MD Stem Cells
- Oct 2027Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study · Barboni
Who these studies take
Of the 13 Optic Nerve Diseases studies recruiting now, 8 (62%) set no upper age limit and 2 (15%) stop at 75 or younger. 3 (23%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (31%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (23%) | 3 (23%) |
| 18 | 9 (69%) | 9 (69%) |
| 30 | 10 (77%) | 10 (77%) |
| 40 | 11 (85%) | 11 (85%) |
| 50 | 13 (100%) | 13 (100%) |
| 65 | 12 (92%) | 12 (92%) |
| 75 | 11 (85%) | 11 (85%) |
| 85 | 10 (77%) | 10 (77%) |
Across all 61 studies, recruiting or not: 26% stop at 75 or younger and 20% at 65; 25% take children; 0% are for women only and 2% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCAOct 21, 2026NCT07508514
Stopped1
- Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.TerminatedOct 23, 2026NCT05353413
Newly registered1
- Subclinical Optic Nerve Changes After Le Fort I OsteotomyNov 9, 2026NCT07925593
Studies
Recruiting first, then most recently updated. Showing 50 of 61. Browse all 61 → or search them.
- Subclinical Optic Nerve Changes After Le Fort I OsteotomyNot yet recruitingNCT07925593
- Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)RecruitingNCT07453888Phase 34 countries
- A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve DamageRecruitingNCT07770685Phase 1/21 country
- Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCARecruitingNCT075085141 country
- Hyperbaric Oxygen Therapy for Optic NeuropathiesRecruitingNCT06128720Not applicable1 country
- NAION in Non-Diabetic Obese Patients Using GLP-1 Receptor Agonists: A Real-World StudyNot yet recruitingNCT078469561 country
- Prospective Evaluation of the 2022 Optic Neuritis Criteria When Optic Neuritis Is SuspectedRecruitingNCT076232521 country
- New Non-invasive Modalities for Assessing Retinal Structure and FunctionRecruitingNCT03475173Not applicable1 country
- Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation ResearchRecruitingNCT07623668Phase 31 country
- DTI & DIR in Optic NeuritisNot yet recruitingNCT07748819
- Optimize Pediatric OCT ImagingRecruitingNCT061395231 country
- Stem Cell Ophthalmology Treatment Study IIRecruitingNCT03011541Not applicable3 countries
- A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With BlindnessRecruitingNCT04634383Not applicable1 country
- Teprotumumab N01 Versus Methylprednisolone After Urgent Orbital Decompression for Dysthyroid Optic NeuropathyNot yet recruitingNCT07594912Phase 21 country
- Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)RecruitingNCT07290244Phase 11 country
- Implementation of the NEDS EyeCTester AppEnrolling by invitationNCT046073691 country
- Advancing Pediatric Retinal Imaging With Auto-aligned OCTRecruitingNCT06841575Not applicable1 country
- Repetitive Transorbital Alternating Current Stimulation for Optic NeuropathiesRecruitingNCT06662448Not applicable1 country
- Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic NeuropathyNot yet recruitingNCT07258667Phase 11 country
- Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center StudyNot yet recruitingNCT07075887
- Clinical Study of FB1001 in PatientsNot yet recruitingNCT06506305Phase 11 country
- STReetlab Assessment Tool of Activities Daily Living in Glaucoma PatientNot yet recruitingNCT05747781Not applicable
- Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.TerminatedNCT05353413Not applicable1 country
- Electrical Stimulation for the Treatment of Optic NeuropathiesActive, not recruitingNCT05626426Not applicable1 country
- Alternating and Direct Current Stimulation for Neuropathic Eye PainCompletedNCT05931250Not applicable1 country
- TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TBCompletedNCT00664313Phase 1/21 country
- Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)CompletedNCT04289909Not applicable1 country
- Building Research With Artificial Intelligence in Neuro-OphthalmologyCompletedNCT063905791 country
- BCI and Evaluation of Visual and Task Performance in Subjects With Eye DiseasesCompletedNCT03318549Not applicable1 country
- Neuromuscular Ultrasonography Assessment of Optic Nerve in Systemic Lupus EryhematosusCompletedNCT058530031 country
- A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple SclerosisCompletedNCT04626921Phase 2/31 country
- Accuracy of the Red Reflex Test in the Pediatric PopulationCompletedNCT041250431 country
- Use of Bevacizumab in Trabeculectomy SurgeryCompletedNCT01166594Phase 41 country
- Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple SclerosisTerminatedNCT03536559Phase 23 countries
- High Resolution Optical Coherence TomographyStatus unknownNCT051303851 country
- Effect of Intraocular Tamponade on Visual PerceptionStatus unknownNCT05543018Not applicable1 country
- Long-Working Distance OCT for ChildrenCompletedNCT02582164Not applicable1 country
- Optic Neuropathy in 10 Patients With Glioblastoma Receiving BevacizumabWithdrawnNCT01331616Early Phase 1
- Retinal Changes in Vitamin D DeficiencyCompletedNCT04891211Not applicable1 country
- Subcutaneous Injection of Erythropoietin on Visual Functions in Patients With Late Onset Optic NeuropathyCompletedNCT04469777Phase 1/21 country
- Trial of Alternating Current Stimulation in Optic NeuropathyCompletedNCT01270126Not applicable1 country
- Biomechanics of Optic NeuropathyTerminatedNCT029824991 country
- Treatment of Optic Neuropathies Using Autologous Bone Marrow-Derived Stem CellsStatus unknownNCT02638714Phase 1/21 country
- Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study)Status unknownNCT02376881Phase 31 country
- Assessment of Visual Function With a Portable Brain-computer InterfaceStatus unknownNCT037600551 country
- Stem Cell Ophthalmology Treatment StudyStatus unknownNCT01920867Not applicable1 country
- Choroidal Thickness in Optic NeuropathyTerminatedNCT023826271 country
- Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic NeuritisStatus unknownNCT04042363Not applicable1 country
- OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic NeuropathyCompletedNCT036428991 country
- Study for Collection of Aflibercept Data in Routine PracticeCompletedNCT028116921 country