Muscular Disorders, Atrophic clinical trials
The registry lists 56 studies for Muscular Disorders, Atrophic across more than 10 countries. 12 are recruiting or about to start. 24 of them are mainly about Muscular Disorders, Atrophic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 6 narrower conditions too, such as Muscular Dystrophy, Duchenne: 858 studies, 198 open.
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Who runs them
McMaster University (5) · Maastricht University Medical Center (5) · Avidity Biosciences, Inc. (3) · PTC Therapeutics (3) · Vertex Pharmaceuticals Incorporated (2) · University of Birmingham (2) · Bispebjerg Hospital (2) · Capricor Inc. (2)
What is being tested here
Drugs under test in Muscular Disorders, Atrophic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men · Indiana University
- Feb 2027A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) · Vertex Pharmaceuticals Incorporated
Who these studies take
Of the 8 Muscular Disorders, Atrophic studies recruiting now, 3 (38%) set no upper age limit and 4 (50%) stop at 75 or younger. 3 (38%) take children under 18. 0 (0%) are for women only and 2 (25%) for men only; 4 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (13%) | 2 (25%) |
| 18 | 5 (63%) | 6 (75%) |
| 30 | 5 (63%) | 6 (75%) |
| 40 | 4 (50%) | 5 (63%) |
| 50 | 4 (50%) | 4 (50%) |
| 65 | 5 (63%) | 5 (63%) |
| 75 | 4 (50%) | 4 (50%) |
| 85 | 3 (38%) | 3 (38%) |
Across all 56 studies, recruiting or not: 70% stop at 75 or younger and 63% at 65; 20% take children; 2% are for women only and 41% for men only; 64% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Muscular Disorders, Atrophic studies take
Of 19 interventional studies with no phase under Muscular Disorders, Atrophic, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo9–25 · 19 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 56. Browse all 56 → or search them.
- A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 SkippingRecruitingNCT07587242Phase 310 countries
- A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic Dystrophy Type IEnrolling by invitationNCT06926621Phase 28 countries
- Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)RecruitingNCT07521930Not applicable1 country
- Managed Access Program for Del-zota in Participants With DMD Mutations Amenable to Exon 44 SkippingAvailableNCT072507371 country
- Effect of Knee Position on Muscle Loss During Leg ImmobilizationNot yet recruitingNCT07690150Not applicable
- Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse ModelNot yet recruitingNCT07615062Not applicable1 country
- An Open-Label Extension Study of PGN-EDODM1 in People With Myotonic Dystrophy Type 1 (FREEDOM-OLE)RecruitingNCT07220603Phase 21 country
- Dietary Strategy to Tackle Cognitive and Locomotor Abilities in Early Elderly SubjectsRecruitingNCT06871384Not applicable1 country
- Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy MenRecruitingNCT07161973Not applicable1 country
- Muscle Response to Different Amounts of Dietary Protein During Leg ImmobilizationRecruitingNCT07069426Not applicable1 country
- Development of IPS from Donated Somatic Cells of Patients with Neurological DiseasesRecruitingNCT008747831 country
- Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement DisordersRecruitingNCT054868061 country
- Human Skeletal Muscle Response to 5 Days of Bedrest in Young AdultsCompletedNCT07178353Not applicable1 country
- Extension of AOC 1001-CS1 (MARINA) Study in Adult Myotonic Dystrophy Type 1 (DM1) PatientsCompletedNCT05479981Phase 21 country
- A Study of Deramiocel (CAP-1002) in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular DystrophyActive, not recruitingNCT05126758Phase 31 country
- A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)Active, not recruitingNCT06185764Phase 1/210 countries
- Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle DisuseActive, not recruitingNCT04151901Not applicable1 country
- Long-Term Outcomes of Ataluren in Duchenne Muscular DystrophyCompletedNCT03179631Phase 318 countries
- Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1CompletedNCT06204809Phase 13 countries
- Prehabilitative Exercise Prior to ImmobilizationCompletedNCT06205784Not applicable1 country
- A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular DystrophyCompletedNCT03406780Phase 21 country
- Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle DisuseCompletedNCT06228742Not applicable1 country
- Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle AtrophyCompletedNCT05314413Not applicable1 country
- n3 PUFA and Muscle-disuse Atrophy in Older WomenTerminatedNCT03808519Not applicable1 country
- The Effects of Protein Supplementation With or Without Urolithin A During Single-leg ImmobilizationActive, not recruitingNCT05814705Not applicable1 country
- Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and UnloadingActive, not recruitingNCT04514744Not applicable1 country
- Phase 3 Trial of Pamrevlumab or Placebo in Combination With Systemic Corticosteroids in Participants With Ambulatory DMDTerminatedNCT04632940Phase 311 countries
- What Are the Effects of Lower Limb Dysmetria on Gluteus Medius and Erector Spinae Musculature?CompletedNCT06217835Not applicable1 country
- Bruxism and Underlying Psichological FactorsStatus unknownNCT062896081 country
- Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy VolunteersCompletedNCT05730842Phase 11 country
- Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young AdultsStatus unknownNCT05760066Not applicable
- The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate PopulationCompletedNCT03454347Not applicable1 country
- The Impact of Bed Rest, Aging and NMES on Skeletal MuscleStatus unknownNCT05617222Not applicable1 country
- Effect of a Natural Source Supplementation on Muscle MassCompletedNCT05369026Not applicable1 country
- Strength Training Augmenting RehabilitationStatus unknownNCT05097092Not applicable1 country
- Blood Flow Restricted Electrical Stimulation During ImmobilisationStatus unknownNCT05093985Not applicable
- Muscle Damage and Disuse AtrophyCompletedNCT03559452Not applicable1 country
- The Expanded Access Use of Viltolarsen in Duchenne Muscular Dystrophy With Confirmed Exon 53 Amenable MutationApproved for marketingNCT04337112
- An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation DystrophinopathyTerminatedNCT02090959Phase 319 countries
- Phase 3 Study of Ataluren in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)CompletedNCT01826487Phase 318 countries
- Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?CompletedNCT03762278Not applicable1 country
- Preventing Bed-rest Induced Muscle Loss in the ElderlyCompletedNCT04422665Not applicable1 country
- The Regulation of Human Skeletal Muscle Mass by Contractile PerturbationCompletedNCT03046095Not applicable1 country
- A Study of LY2495655 in Older Participants Undergoing Elective Total Hip ReplacementCompletedNCT01369511Phase 211 countries
- Neuromuscular Electrical Stimulation During Immobilization Due to Ankle FracturesTerminatedNCT02469506Not applicable1 country
- Activity Dependent Rehabilitation Model to Improve Bone and Muscle OutcomesStatus unknownNCT02309983Not applicable1 country
- Bedrest, Feeding Pattern, and Insulin SensitivityCompletedNCT02521025Not applicable1 country
- Bed-rest, Muscle Mass and Insulin SensitivityCompletedNCT02109380Not applicable1 country
- A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male VolunteersCompletedNCT01943513Phase 11 country
- Effects of Kneehab 12-week Peri-operative Total Knee ArthroplastyCompletedNCT01096524Phase 31 country