An interventional study of Resistance Training Preconditioning and Control in Atrophy, Disuse and Atrophy, Muscular, sponsored by Auburn University. Status unknown. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-03-08.
Sponsored by Auburn University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. The main questions it aims to answer are:
Participants will:
Researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.
51 studies on the registry are indexed under Muscular Disorders, Atrophic; 11 are open to participants now.
This study's planned enrollment of 24 is close to the median of 24 across 48 interventional studies indexed under Muscular Disorders, Atrophic.
Browse Muscular Disorders, Atrophic studies →Auburn University is the lead sponsor of 72 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
This group will perform: 1. 6 weeks of lower body focused resistance training 2. 2 weeks of locking brace-induced immobilization of a randomized leg 3. 6 weeks of lower body focused resistance training
Other: Resistance Training Preconditioning
This group will perform: 1. 6 weeks of activities of daily living (no training) 2. 2 weeks of locking brace-induced immobilization of a randomized leg 3. 6 weeks of lower body focused resistance training
Other: Control
Resistance training prior to disuse-induced atrophy followed by another period of resistance training
Activities of daily living prior to disuse-induced atrophy followed by a period of resistance training
Change in vastus lateralis fiber cross-sectional area
Upon the procurement and analysis of muscle from the vastus lateralis of participants, histological techniques will be used to assess fiber cross-sectional area of muscle fibers
Time frame: Through completion of study, 16 weeks
Change in quadriceps strength via 3 repetition maximum testing
Strength of the quadriceps will be assessed via 3-repetition maximum testing of select exercises (leg press, leg extension, hex-bar deadlift)
Time frame: Through completion of study, 16 weeks
Change in quadriceps strength via isokinetic dynamometry
Strength of the quadriceps will be assessed via isokinetic dynamometry
Time frame: Through completion of study, 16 weeks
Change in protein expression of anabolic signaling proteins
Western blotting will be performed and quantified in relative fluorescence units for proteins involved in the mechanistic target of rapamycin signaling pathway.
Time frame: Through completion of study, 16 weeks
Change in protein expression of catabolic signaling proteins
Western blotting will be performed and quantified in relative fluorescence units for proteins involved in the catabolic signaling pathways (e.g. ubiquitin-proteasome system, calpain system, autophagy).
Time frame: Through completion of study, 16 weeks
Change in activity of catabolic systems
Activity assays will be performed and quantified in relative fluorescence units normalized to muscle soluble protein abundance in order to quantify the activity of the calpain system and the 20S proteasome core.
Time frame: Through completion of study, 16 weeks
Gene expression at the mRNA level of atrophy-associated genes (atrogenes)
Real time quantitative polymerase chain reactions (qPCR) will be used to quantify the expression of select genes associated with atrophy. These data will be reported as fold-change from baseline and will be normalized to one or more housekeeping genes whose value does not change throughout the duration of the study.
Time frame: Through completion of study, 16 weeks
No study locations are listed for this record.
This study is status unknown, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Auburn University