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CompletedNCT02109380Updated Apr 28, 2015

Bed-rest, Muscle Mass and Insulin Sensitivity

An interventional study of Bed rest in Disuse Atrophy, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-28.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
15
Allocation
Not applicable
Ages
18 Years to 35 Years
Sex
Male
01

Study summary

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

02

Conditions studied

  • Disuse Atrophy
03

In context

Muscular Disorders, Atrophic

51 studies on the registry are indexed under Muscular Disorders, Atrophic; 11 are open to participants now.

This study's enrollment of 15 is below the median of 24 across 48 interventional studies indexed under Muscular Disorders, Atrophic.

Browse Muscular Disorders, Atrophic studies →

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • Male
  • Aged from 18-35 years
  • 18.5 \< BMI \< 30 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Smoking
  • Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
  • Hypertension (according to WHO criteria) and/or cardiovascular disease
  • Any back/leg/knee/neck/postural complaints
  • Use of any prescribed medication
  • Type 2 diabetes mellitus
  • Any family history of thrombosis
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
  • Myocardial infarction within the last 3 years
  • Use of anti-coagulants
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
15 participants (actual)

Study arms

  • Experimental
    Bed rest

    One week of bed rest.

    Behavioral: Bed rest

Interventions

  • BehavioralBed rest
06

What researchers measure

Primary outcomes

  1. Change in quadriceps muscle cross-sectional area

    Time frame: One day before and directly after cessation of bed rest.

Secondary outcomes

  1. Change in lower back cross-sectional area

    Time frame: One day before and directly after cessation of bed rest.

  2. Change in leg and whole body lean tissue mass

    Time frame: One day before and directly after cessation of bed rest.

  3. Change in muscle fiber size

    Time frame: One day before and directly after cessation of bed rest.

  4. Change in muscle strength

    Measured by 1-Repetition Maximum testing

    Time frame: One day before and directly after cessation of bed rest.

  5. Change in insulin sensitivity

    Measured by hyperinsulinemic-euglycemic clamp

    Time frame: One day before and directly after cessation of bed rest.

07

Study locations

1 site
  • Maastricht University Medical Centre
    Maastricht, Netherlands
08

References and documents

Publications

  • Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJ. One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes. 2016 Oct;65(10):2862-75. doi: 10.2337/db15-1661. Epub 2016 Jun 29. PubMed 27358494 ↗
  • Dirks ML, Backx EM, Wall BT, Verdijk LB, van Loon LJ. May bed rest cause greater muscle loss than limb immobilization? Acta Physiol (Oxf). 2016 Sep;218(1):10-2. doi: 10.1111/apha.12699. Epub 2016 May 20. No abstract available. PubMed 27124248 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 28, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02109380
Lead sponsor
Maastricht University Medical Center
Responsible party
Lex Verdijk (Assistant Professor, Maastricht University Medical Center) — Principal investigator
First posted
Apr 9, 2014
Start date
Jun 2014
Primary completion
Apr 2015
Last update
Apr 28, 2015

Study contacts

Luc JC van Loon, PhD
principal investigator · Maastricht UMC

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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