A Phase 2 interventional study of PGN-EDODM1 in Myotonic Dystrophy 1, sponsored by PepGen Inc. Recruiting at 3 sites in Canada. Per ClinicalTrials.gov, last updated 2026-03-30.
Sponsored by PepGen Inc · Phase 2, Interventional, and Treatment
The purpose of this study is to learn about the long-term safety and tolerability of PGN-EDODM1 in participants with myotonic dystrophy type 1 (DM1) who have completed a prior study with PGN-EDODM1.
126 studies on the registry are indexed under Myotonic Dystrophy; 50 are open to participants now.
This study's planned enrollment of 48 is above the median of 40 across 67 interventional studies indexed under Myotonic Dystrophy.
Browse Myotonic Dystrophy studies →PepGen Inc is the lead sponsor of 5 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Clinically significant
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive doses of PGN-EDODM1 once every 4 weeks (Q4W)
Drug: PGN-EDODM1
Administered by intravenous (IV) infusion
Safety and tolerability as assessed by number of participants with Adverse Events (AEs)
Time frame: Baseline through Week 108
Started Dec 2025 (actual). Primary completion is estimated for Jan 2029, 37 months after the start.
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PepGen Inc