An interventional study of Orthopedic immobilization and Unilateral resistance training in Muscle Disuse Atrophy, sponsored by Texas Christian University. Status unknown at 2 sites in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-10-27.
Sponsored by Texas Christian University · Not applicable, Interventional, and Treatment
This project aims to determine whether a novel strength training rehabilitation protocol can diminish the negative consequences of limb immobilization and expedite the restoration of muscle function during retraining in healthy individuals.
The present study will examine the time course of muscle strength and size adaptations in two groups of volunteers during immobilization and retraining. Both groups will undergo temporary muscle disuse by wearing a shoulder sling and swathe on their non-dominant arm for \~≥10 hours/day for four weeks. One group (immobilization + unilateral training) will perform progressive unilateral strength training of the free limb throughout the immobilization period. The other group (immobilization control) will not undergo any training during the immobilization period. Following immobilization, both groups will undergo four weeks of bilateral strength training to retrain the immobilized arm.
51 studies on the registry are indexed under Muscular Disorders, Atrophic; 11 are open to participants now.
This study's planned enrollment of 20 is below the median of 24 across 48 interventional studies indexed under Muscular Disorders, Atrophic.
Browse Muscular Disorders, Atrophic studies →Texas Christian University is the lead sponsor of 33 studies on the registry; 6 are open to participants now.
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Exclusion Criteria:
The immobilization control group will undergo arm immobilization. Immobilization will be implemented with four weeks of muscle unloading with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body.
Procedure: Orthopedic immobilization · Other: Bilateral resistance training
The immobilization with unilateral training group will undergo arm immobilization for four with a sling and swathe on the nondominant arm. The sling will suspend the arm at the elbow joint with the elbow in a flexed position at 90°, the swathe will then wrap around the participant to fix the arm against the body. The free (non-immobilzed) arm of this group will undergo heavy strength training twice per week throughout the immobilization period. The training will consist of unilateral dumbbell shoulder press and biceps curl.
Procedure: Orthopedic immobilization · Other: Unilateral resistance training · Other: Bilateral resistance training
Orthopedic immobilization will be performed with a sling and swathe.
Unilateral resistance training will be performed by the dominant arm of the immobilization + unilateral resistance training group during Phase 1.
Bilateral resistance training will be performed by both arms in both groups during Phase 2.
Changes in isometric muscle strength
MVC (Newton)
Time frame: Changes from baseline at 5 and 10 weeks
Changes in dynamic muscle strength
1RM (lbs)
Time frame: Changes from baseline at 5 and 10 weeks
Changes in muscle size
Ultrasound muscle thickness of biceps brachii and triceps brachii
Time frame: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
Changes in lean mass
DEXA
Time frame: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
Changes in EMG amplitude
Surface EMG
Time frame: Changes from baseline at 5 and 10 weeks
Changes in action potential amplitude
Surface EMG Decomposition
Time frame: Changes from baseline at 5 and 10 weeks
This study is status unknown, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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