Muscular Atrophy: all 503 studies

Page 2 of 6. Open to participants first (94), then studies with results posted, then the rest; newest registration first within each.

• Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or RisdiplamCompletedNCT05386680Phase 3Results posted
• Electrical Stimulation for Critically Ill Post-Covid-19 PatientsCompletedNCT05198466Phase 2Results posted
• Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA)CompletedNCT05089656Phase 3Results posted
• Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (OFELIA)CompletedNCT05073133Phase 4Results posted
• Ruxolitinib for Cancer CachexiaActive, not recruitingNCT04906746Early Phase 1Results posted
• Vascular Dysfunction During Physical InactivityCompletedNCT04872998Not applicableResults posted
• Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)CompletedNCT04851873Phase 3Results posted
• Electrical Stimulation for Critically Ill Covid-19 PatientsCompletedNCT04685213Phase 1Results posted
• Blood Flow Restriction After Meniscus RepairTerminatedNCT04436523Not applicableResults posted
• Mechanisms Underlying Local and Systemic Effects of MassageCompletedNCT04131712Not applicableResults posted
• Study of Nusinersen (BIIB058) in Participants With Spinal Muscular AtrophyCompletedNCT04089566Phase 3Results posted
• A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy ParticipantsCompletedNCT03988907Phase 1Results posted
• An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular AtrophyCompletedNCT03921528Phase 2Results posted
• A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic FunctionCompletedNCT03920865Phase 1Results posted
• Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3TerminatedNCT03819660Phase 2Results posted
• Controlled Trial to Evaluate Amifampridine Phosphate in Spinal Muscular Atrophy Type 3 PatientsCompletedNCT03781479Phase 2Results posted
• Whole Body Vibration Therapy in Children With Spinal Muscular AtrophyTerminatedNCT03056144Not applicableResults posted
• Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular AtrophyCompletedNCT02913482Phase 2Results posted
• A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) ParticipantsCompletedNCT02908685Phase 2Results posted
• A Study of CK-2127107 in Patients With Spinal Muscular AtrophyCompletedNCT02644668Phase 2Results posted
• A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA)CompletedNCT02628743Phase 2Results posted
• A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational StudiesCompletedNCT02594124Phase 3Results posted
• Preventing the Loss of Muscle and Function in Hospitalized Older AdultsCompletedNCT02566590Not applicableResults posted
• A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).TerminatedNCT02462759Phase 2Results posted
• Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL TearsCompletedNCT02420353Phase 2Results posted
• A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)CompletedNCT02292537Phase 3Results posted
• An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)CompletedNCT02268552Phase 1/2Results posted
• WREX Outcome StudyCompletedNCT02218593Results posted
• A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular AtrophyTerminatedNCT02193074Phase 3Results posted
• Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture SurgeryCompletedNCT02152761Phase 2Results posted
• Mechanistic Approach to Preventing Atrophy and Restoring Function in Older AdultsCompletedNCT02145949Phase 2Results posted
• Gene Transfer Clinical Trial for Spinal Muscular Atrophy Type 1CompletedNCT02122952Phase 1Results posted
• Safety, Tolerability, and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT02024932Phase 2Results posted
• A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)CompletedNCT01839656Phase 2Results posted
• Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of DevelopmentCompletedNCT01736553Results posted
• An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular AtrophyCompletedNCT01703988Phase 1/2Results posted
• Short and Long Term Treatment With 4-AP in Ambulatory SMA PatientsCompletedNCT01645787Phase 2/3Results posted
• Testosterone Administration and ACL Reconstruction in MenCompletedNCT01595581Phase 3Results posted
• Flu Vaccine Study in Neuromuscular Patients 2011CompletedNCT01422200Phase 4Results posted
• Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle WastingTerminatedNCT01388920Phase 2Results posted
• A Study of LY2495655 in Older Participants Undergoing Elective Total Hip ReplacementCompletedNCT01369511Phase 2Results posted
• Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line PlatinumCompletedNCT01355497Phase 3Results posted
• Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01355484Phase 3Results posted
• Progressive Strength Training in Spinal Muscular AtrophyCompletedNCT01233817Not applicableResults posted
• Reducing Falls With RENEW in Older Adults Who Have FallenCompletedNCT01080196Not applicableResults posted
• CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type ICompletedNCT00661453Phase 1/2Results posted
• A Pilot Therapeutic Trial Using Hydroxyurea in Type II and Type III Spinal Muscular Atrophy PatientsCompletedNCT00568802Phase 1/2Results posted
• A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy PatientsCompletedNCT00568698Phase 1/2Results posted
• Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular AtrophyCompletedNCT00528268Phase 1/2Results posted
• 5-Alpha Reductase and Anabolic Effects of TestosteroneCompletedNCT00475501Phase 2Results posted
• Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.CompletedNCT00467844Phase 2Results posted
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or IIITerminatedNCT00439569Phase 1/2Results posted
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type ITerminatedNCT00439218Phase 1/2Results posted
• Dutasteride to Treat Spinal and Bulbar Muscular Atrophy (SBMA)CompletedNCT00303446Phase 2Results posted
• Valproic Acid and Carnitine in Patients With Spinal Muscular AtrophyCompletedNCT00227266Phase 2Results posted
• Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older AdultsCompletedNCT07689487Not applicable
• Isokinetic Muscle Strength, Torque, Ultrasonographic Muscle Thickness in Fibromyalgia Syndrome: A Case-Control StudyCompletedNCT07649824
• Resistance Training Adaptations and Caffeine IntakeCompletedNCT07410195Not applicable
• Post-surgery Muscle Preservation and Pain Reduction Through Blood Flow Restriction Training in Orthopedic Spinal SurgeryCompletedNCT06962683Not applicable
• Effect of Enteral Formula (Commercial vs. Homemade) on Muscle Mass in Trauma Brain InjuryCompletedNCT06949163Not applicable
• Impact of Blood Flow Restriction and Electrical Stimulation on Postoperative Muscle Atrophy and Pain After Total Knee ArthroplastyCompletedNCT06944808Not applicable
• Using Continuous Passive Motion to Prevent Ankle Problems in ICU PatientsCompletedNCT06944431Not applicable
• Clinical-randomized Study of the Influence of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Total Knee ArthroplastyCompletedNCT06942065Not applicable
• Effects of Passive Blood-Flow-Restriction on Muscle Atrophy and Pain After Elective Total Knee ArthroplastyCompletedNCT06928181Not applicable
• Effects of Overground Robot-Assisted Gait Training on Stroke-Related SarcopeniaCompletedNCT06910254Not applicable
• Trapezius Muscle Activities in the Natural Head Posture and Corrected Head Posture During Wall-Slide ExerciseCompletedNCT06872957
• Impact of Motor and Oral Motor Function on Quality of Life in Children With SMACompletedNCT06864767
• GLP-1s to Enhance Lasting Optimal WeightActive, not recruitingNCT06861439Phase 4
• Gluteal Sling Release on Gluteal Dysfunction After in Primary Total Hip ArthroplastyCompletedNCT06850155Not applicable
• Therapeutic Management and Use of Resources and Costs of Spinal Muscular Atrophy in SpainCompletedNCT06632730
• Ultrasonographic Muscle Assessment and Functional Scales in Spinal Muscular AtrophyActive, not recruitingNCT06599606
• Clinical Trial to Evaluate the Safety and Efficacy of EXG001-307 in Patients With Spinal Muscular Atrophy Type ICompletedNCT06576388Early Phase 1
• Preoperative Gluteal Muscle Atrophy: A Silent Predictor of THA Dislocation.CompletedNCT06571604
• Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older AdultsCompletedNCT06556706Not applicable
• Efficacy of a Water Intervention in Institutionalized Aged Population.CompletedNCT06497426Not applicable
• Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.CompletedNCT06458530Not applicable
• Plant Protein Blend and Milk Protein Supplements in Older IndividualsCompletedNCT06403137Not applicable
• Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg DisuseCompletedNCT06350591Not applicable
• Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight MgmtCompletedNCT06282458Phase 2
• Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in AdultsCompletedNCT06233825Not applicable
• Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle DisuseCompletedNCT06228742Not applicable
• Effects of the Combined Intervention of Exercise, Fruit, and Vitamin Supplementation on Frailty in Older AdultsActive, not recruitingNCT06225271Not applicable
• Prehabilitative Exercise Prior to ImmobilizationCompletedNCT06205784Not applicable
• Two Different Treatment Modalities in Patients With Spinal Muscular AtrophyCompletedNCT06178653Not applicable
• Real-World Use of Novel Treatments in Patients With Spinal Muscular Atrophy (SMA): A Multi-Site Retrospective Chart Review of Pediatric SMA Patients Outside of the United StatesCompletedNCT06178393
• Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical IllnessCompletedNCT06167772Not applicable
• Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver DiseaseActive, not recruitingNCT06136221Not applicable
• Indicator Amino Acid Oxidation in ICU PatientsCompletedNCT06104527Not applicable
• Effect of Branched-chain Amino Acid Supplementation and Exercise on Muscle Quantity and Quality in CirrhosisCompletedNCT06088550Not applicable
• Muscle Stem Cell Quality in AtrophyTerminatedNCT06077734
• MCT8 Deficiency Caregiver StudyCompletedNCT06060197
• Bilateral Versus Unilateral Strength Training After ACLRWithdrawnNCT06032247Not applicable
• Genetic Newborn Screening for Cystinosis and Spinal Muscular AtrophyCompletedNCT06027385Not applicable
• Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in HumansActive, not recruitingNCT05997095Not applicable
• Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older MenCompletedNCT05927623Not applicable
• The Effect of Spinal Orthosis on the Development of Scoliosis and Chest Deformity in Type I Spinal Muscular AtrophyCompletedNCT05878418Not applicable
• Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALSWithdrawnNCT05830214
• Effect of an Aquatic Exercise Program in Patients With Chronic Low Back PainCompletedNCT05823857Not applicable
• Energy Balance in Extreme Environments: Finding the EI LimitCompletedNCT05773469
• Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and WellbeingCompletedNCT05769101Not applicable

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